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Träfflista för sökning "L773:0957 4166 OR L773:1362 511X srt2:(1995-1999)"

Search: L773:0957 4166 OR L773:1362 511X > (1995-1999)

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  • Berglund, Per, et al. (author)
  • Switched enantiopreference of Humicola lipase for 2-phenoxyalkanoic acid ester homologs can be rationalized by different substrate binding modes
  • 1999
  • In: Tetrahedron. - 0957-4166 .- 1362-511X. ; 10:21, s. 4191-4202
  • Journal article (peer-reviewed)abstract
    • Humicola lanuginosa lipase was used for enantioselective hydrolyses of a series of homologous 2-phenoxyalkanoic acid ethyl esters. The enantioselectivity (E-value) of the enzyme changed from an (R)-enantiomer preference for the smallest substrate, 2-phenoxypropanoic acid ester, to an (S)-enantiomer preference for the homologous esters with longer acyl moieties. The E-values span the range from E=13 (R) to E=56 (S). A molecular modeling study identified two different substrate-binding modes for each enantiomer. We found that the enantiomers favored different modes. This discovery provided a model that offered a rational explanation for the observed switch in enantioselectivity. (C) 1999 Elsevier Science Ltd. All rights reserved.
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  • Result 1-8 of 8

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