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- Guliashvili, T., et al.
(author)
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The first isolable 2-silenolate
- 2003
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In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 42:14, s. 1640-1642:42, s. 1640-1642
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Journal article (peer-reviewed)
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- Kaiser, N. F. K., et al.
(author)
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Fast, convenient, and efficient molybdenum-catalyzed asymmetric allylic alkylation under noninert conditions : An example of microwave-promoted fast chemistry
- 2000
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In: Angewandte Chemie International Edition. - Univ Uppsala, Dept Organ Pharmaceut Chem, Uppsala Biomed Ctr, S-75123 Uppsala, Sweden. Royal Inst Technol, Dept Chem, S-10044 Stockholm, Sweden.. - 1433-7851 .- 1521-3773. ; 39, s. 3595-
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Journal article (peer-reviewed)
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- Kirby, A J, et al.
(author)
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Gemini surfactants: New synthetic vectors for gene transfection
- 2003
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In: Angewandte Chemie International Edition in English. - : Wiley. - 0570-0833 .- 1433-7851 .- 1521-3773. ; 42:13, s. 1448-1457
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Research review (peer-reviewed)abstract
- The superior surfactant properties of cationic gemini surfactants are applied to the complex problem of introducing genes into cells. Of almost 250 new compounds tested, of some 20 different structural types, a majority showed very good transfection activity in vitro. The surfactant is shown to bind and compact DNA efficiently, and structural studies and calculations provide a working picture of the lipoplex formed. The lipoplex can penetrate the outer membranes of many cell types, to appear in the cytoplasm encapsulated within endosomes. Escape from the endosome - a key step for transfection - may be controlled by changes in the aggregation behavior of the lipoplex as the pH falls. The evidence suggests that DNA may be released from the lipoplex before entry into the nucleus, where the new gene can be expressed with high efficiency.
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- Larsson, Rikard, et al.
(author)
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Catalytic Self-Screening of Cholinesterase Substrates from a Dynamic Combinatorial Thioester Library
- 2004
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In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 43:28, s. 3716-3718
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Journal article (peer-reviewed)abstract
- Simply the best: Dynamic combinatorial chemistry coupled to enzyme catalysis was used to identify enzyme substrates in a library constructed from a series of thioesters and thiols by transesterification. The library was directly coupled to the catalytic action of acetylcholinesterase, which selectively hydrolyzed the best substrate candidates (see schematic representation). The process allowed rapid identification of discrete substrates.
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- Lindsjö, Martin, et al.
(author)
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Sb8[GaCl4]2: Isolation of a Homopolyatomic Antimony Cation
- 2004
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In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 43:19, s. 2540-2543
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Journal article (peer-reviewed)abstract
- An almost perfect square-antiprismatic geometry is observed for Sb 82+ (see picture), as predicted by the Wade rules. The title compound, which was synthesized in benzene at room temperature, represents the first homopolyatomic antimony cation and has Sb-Sb bond lengths of 285-300 pm.
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