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Träfflista för sökning "L773:1469 5111 OR L773:1461 1457 srt2:(2000-2004)"

Search: L773:1469 5111 OR L773:1461 1457 > (2000-2004)

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  • Annerbrink, Kristina, 1974, et al. (author)
  • Serotonin depletion increases respiratory variability in freely moving rats: implications for panic disorder.
  • 2003
  • In: The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). - 1469-5111. ; 6:1, s. 51-6
  • Journal article (peer-reviewed)abstract
    • To elucidate if serotonergic transmission affects respiratory variability, a parameter consistently found increased in patients with panic disorder, we studied the effect of a serotonin synthesis inhibitor, para-chlorophenylalanine (PCPA), on respiratory variability at baseline and during CO2-induced hyperventilation in awake and unrestrained rats. Forty male Wistar rats were given intraperitoneal injections of PCPA (300 mg/kg) or saline 72, 48 and 24 h before registration of respiration in a plethysmograph allowing the animals to move freely. PCPA-treated rats displayed significantly higher tidal volume variability and minute volume variability, both at baseline and during CO2 exposure, compared to controls. The results support the notion that serotonin dysfunction may contribute to the enhanced respiratory variability observed in patients with panic disorder.
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  • Farde, L, et al. (author)
  • A PET study of
  • 2000
  • In: The international journal of neuropsychopharmacology. - 1469-5111. ; 3:3, s. 203-214
  • Journal article (peer-reviewed)
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