| 1. |
- Ellegren, Hans
(author)
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Sex-chromosome evolution : recent progress and the influence of male and female heterogamety
- 2011
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 12:3, s. 157-166
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Research review (peer-reviewed)abstract
- It is now clear that sex chromosomes differ from autosomes in many aspects of genome biology, such as organization, gene content and gene expression. Moreover, sex linkage has numerous evolutionary genetic implications. Here, I provide a coherent overview of sex-chromosome evolution and function based on recent data. Heteromorphic sex chromosomes are almost as widespread across the animal and plant kingdoms as sexual reproduction itself and an accumulating body of genetic data reveals interesting similarities, as well as dissimilarities, between organisms with XY or ZW sex-determination systems. Therefore, I discuss how patterns and processes associated with sex linkage in male-and female-heterogametic systems offer a useful contrast in the study of sex-chromosome evolution.
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| 2. |
- Forsberg, Joanna Stjernschantz, et al.
(author)
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A big step for Finnish biobanking
- 2014
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 15:1, s. 6-6
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Journal article (other academic/artistic)
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| 3. |
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| 4. |
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| 5. |
- Holmberg, J, et al.
(author)
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Maintaining differentiated cellular identity
- 2012
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In: Nature reviews. Genetics. - : Springer Science and Business Media LLC. - 1471-0064 .- 1471-0056. ; 13:6, s. 429-439
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Journal article (peer-reviewed)
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| 6. |
- Kaye, Jane, et al.
(author)
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From patients to partners : participant-centric initiatives in biomedical research.
- 2012
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 13:5, s. 371-6
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Journal article (peer-reviewed)abstract
- Advances in computing technology and bioinformatics mean that medical research is increasingly characterized by large international consortia of researchers that are reliant on large data sets and biobanks. These trends raise a number of challenges for obtaining consent, protecting participant privacy concerns and maintaining public trust. Participant-centred initiatives (PCIs) use social media technologies to address these immediate concerns, but they also provide the basis for long-term interactive partnerships. Here, we give an overview of this rapidly moving field by providing an analysis of the different PCI approaches, as well as the benefits and challenges of implementing PCIs.
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| 7. |
- Mascalzoni, Deborah, et al.
(author)
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Rare diseases and now rare data?
- 2013
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 14:6, s. 372-372
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Journal article (other academic/artistic)
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| 8. |
- Parsch, J., et al.
(author)
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The evolutionary causes and consequences of sex-biased gene expression
- 2013
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 14:2, s. 83-87
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Research review (peer-reviewed)abstract
- Females and males often differ extensively in their physical traits. This sexual dimorphism is largely caused by differences in gene expression. Recent advances in genomics, such as RNA sequencing (RNA-seq), have revealed the nature and extent of sex-biased gene expression in diverse species. Here we highlight new findings regarding the causes of sex-biased expression, including sexual antagonism and incomplete dosage compensation. We also discuss how sex-biased expression can accelerate the evolution of sex-linked genes.
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| 9. |
- Savolainen, Outi, et al.
(author)
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Ecological genomics of local adaptation
- 2013
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In: Nature reviews genetics. - : Springer Science and Business Media LLC. - 1471-0056 .- 1471-0064. ; 14:11, s. 807-820
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Research review (peer-reviewed)abstract
- It is increasingly important to improve our understanding of the genetic basis of local adaptation because of its relevance to climate change, crop and animal production, and conservation of genetic resources. Phenotypic patterns that are generated by spatially varying selection have long been observed, and both genetic mapping and field experiments provided initial insights into the genetic architecture of adaptive traits. Genomic tools are now allowing genome-wide studies, and recent theoretical advances can help to design research strategies that combine genomics and field experiments to examine the genetics of local adaptation. These advances are also allowing research in non-model species, the adaptation patterns of which may differ from those of traditional model species.
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| 10. |
- Schwartz, Yuri B., et al.
(author)
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A new world of Polycombs : unexpected partnerships and emerging functions
- 2013
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In: Nature reviews genetics. - : Nature Publishing Group. - 1471-0056 .- 1471-0064. ; 14:12, s. 853-864
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Research review (peer-reviewed)abstract
- Polycomb group (PcG) proteins are epigenetic repressors that are essential for the transcriptional control of cell differentiation and development. PcG-mediated repression is associated with specific post-translational histone modifications and is thought to involve both biochemical and physical modulation of chromatin structure. Recent advances show that PcG complexes comprise a multiplicity of variants and are far more biochemically diverse than previously thought. The importance of these new PcG complexes for normal development and disease, their targeting mechanisms and their shifting roles in the course of differentiation are now the subject of investigation and the focus of this Review.
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