| 1. |
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| 2. |
- Dahlén, Gunnar, 1944, et al.
(author)
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Necrobacillosis in humans.
- 2011
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In: Expert review of anti-infective therapy. - : Informa UK Limited. - 1744-8336 .- 1478-7210. ; 9:2, s. 227-36
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Journal article (peer-reviewed)abstract
- Necrobacillosis, often used synonymously with Lemierre's syndrome, is a form of abscess infection in the peritonsillar area associated with a thrombophlebitis and caused by the strict anaerobic species Fusobacterium necrophorum. The thrombosis formed affects the internal jugular vein, from which the bacteria are seeded out in the bloodstream and cause bacteremia. Septicemia is a common complication with an often fatal outcome. Necrobacillosis is very rare and is referred to as the 'forgotten disease'. It is probably frequently overlooked in clinical practice in its early and milder forms such as tonsillitis (sore throat) and peritonsillar abscess. F. necrophorum frequently participates in these infections and is thus suspected to have an etiological role in Lemierre's syndrome. Similarly, F. necrophorum seems to play an important role in noma (cancrum oris) and this disease is also included in the necrobacillosis complex. Diagnosis of infections of the necrobacillosis complex seeks to disclose F. necrophorum in swab samples or blood culture. The most commonly used therapy is metronidazole in combination with penicillin or amoxicillin. Clindamycin is also an option, especially in cases of penicillin allergy.
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| 3. |
- Klingström, Jonas, et al.
(author)
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Hantavirus protein interactions regulate cellular functions and signaling responses
- 2011
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In: Expert Review of Anti-Infective Therapy. - : Informa UK Limited. - 1478-7210 .- 1744-8336. ; 9:1, s. 33-47
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Journal article (peer-reviewed)abstract
- Rodent-borne pathogenic hantaviruses cause two severe and often lethal zoonotic diseases: hemorrhagic fever with renal syndrome (HFRS) in Eurasia and hantavirus cardiopulmonary syndrome (HCPS) in the Americas. Currently, no US FDA-approved therapeutics or vaccines are available for HFRS/HCPS. Infections with hantaviruses are not lytic, and it is currently not known exactly why infections in humans cause disease. A better understanding of how hantaviruses interfere with normal cell functions and activation of innate and adaptive immune responses might provide clues to future development of specific treatment and/or vaccines against hantavirus infection. In this article, the current knowledge regarding immune responses observed in patients, hantavirus interference with cellular proteins and signaling pathways, and possible approaches in the development of therapeutics are discussed.
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| 4. |
- Olofsson, Sigvard, 1948, et al.
(author)
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PCR for detection of respiratory viruses: seasonal variations of virus infections
- 2011
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In: EXPERT REVIEW OF ANTI-INFECTIVE THERAPY. - 1478-7210. ; 9:8, s. 615-626
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Research review (peer-reviewed)abstract
- Real-time PCR and related methods have revolutionized the laboratory diagnosis of viral respiratory infections because of their high detection sensitivity, rapidness and potential for simultaneous detection of 15 or more respiratory agents. Results from studies with this diagnostic modality have significantly expanded our knowledge about the seasonality of viral respiratory diseases, pinpointed the difficulties to make a reliable etiologic diagnosis without the aid of an unbiased multiplex molecular assay for respiratory viruses, and revealed previously unknown details as to possible infections with multiple agents as aggravating factors. The scope of this article is to review and discuss this new knowledge and its implications for diagnostic strategies and other measures essential for the clinical management of respiratory viral infections and for epidemiological surveillance of seasonal respiratory infections.
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| 5. |
- Sköld, Ola
(author)
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Sulfonamides and trimethoprim
- 2010
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In: Expert review of anti-infective therapy. - : Informa UK Limited. - 1744-8336 .- 1478-7210. ; 8:1, s. 1-6
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Journal article (other academic/artistic)
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| 6. |
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| 7. |
- Unemo, Magnus, 1970-, et al.
(author)
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Challenges with gonorrhea in the era of multi-drug and extensively drug resistance -are we on the right track?
- 2014
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In: Expert Review of Anti-Infective Therapy. - : Expert reviews. - 1478-7210 .- 1744-8336. ; 12:6, s. 653-656
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Journal article (peer-reviewed)abstract
- Neisseriagonorrhoeae has retained antimicrobial resistance to drugs previously recommended for first-line empiric treatment of gonorrhea, and resistance to ceftriaxone, the last option for monotherapy, is evolving. Crucial actions to combat this developing situation include implementing response plans; considering use of dual antimicrobial regimens; enhancing surveillance of gonorrhea, gonococcal antimicrobial resistance, treatment failures and antimicrobial use/misuse and improving prevention, early diagnosis, contact tracing and treatment. The ways forward also include an intensified research to identify novel antimicrobial resistance determinants and develop and evaluate appropriate use of molecular antimicrobial resistance testing, ideally point-of-care and with simultaneous detection of gonococci, to supplement culture-based methods and ideally guide tailored treatment. It is crucial with an enhanced understanding of the dynamics of the national and international emergence, transmission and evolution of antimicrobial-resistant gonococcal strains. Genome sequencing combined with epidemiological metadata will detail these issues and might also revolutionize the molecular antimicrobial resistance testing. Ultimately, novel antimicrobials are essential and some antimicrobials in development have shown potent in vitro activity against gonococci. Several of these antimicrobials deserve further attention for potential future treatment of gonorrhea.
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| 8. |
- Unemo, Magnus, 1970-
(author)
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Holistic actions are essential to combat the global public health burden of non-viral sexually transmitted infections : challenges and future perspectives
- 2014
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In: Expert Review of Anti-Infective Therapy. - : Expert reviews. - 1478-7210 .- 1744-8336. ; 12:6, s. 649-651
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Journal article (peer-reviewed)abstract
- Sexually transmitted infections (STIs) represent a significant international public health burden. These infections result in substantial morbidity, mortality and economic costs globally, and require more attention and resources internationally. This special focus issue of Expert Review of Anti Infective Therapy invited key opinion leaders to review and discuss the challenges associated with the diagnosis and treatment of non-viral STIs. The issue also elucidates the future perspectives, ways forward and holistic actions imperative to effectively combat these STIs.
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