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Träfflista för sökning "L773:1529 2908 OR L773:1529 2916 srt2:(2000-2004)"

Search: L773:1529 2908 OR L773:1529 2916 > (2000-2004)

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  • Karaghiosoff, M, et al. (author)
  • Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock
  • 2003
  • In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 4:5, s. 471-477
  • Journal article (peer-reviewed)abstract
    • Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-P (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression of IFN-beta and IFN-alpha4 mRNA in Tyk2-null macrophages were diminished. However, Tyk2-null mice showed normal systemic production of nitric oxide and proinflammatory cytokines and the in vivo response to tumor necrosis factor (TNF) was unperturbed. IFN-beta-null but not STAT1-null mice were also resistant to high dose LPS treatment. Together, these data suggest that Tyk2 and IFN-beta are essential effectors in LPS induced lethality.
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  • Karre, K (author)
  • Clever, cleverer, cleverest
  • 2002
  • In: Nature immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 3:6, s. 505-506
  • Journal article (other academic/artistic)
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  • Pan, Q, et al. (author)
  • Lack of IgA in C(mu)-deficient patients
  • 2002
  • In: Nature immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 3:7, s. 595-595
  • Journal article (other academic/artistic)
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  • Result 1-10 of 12

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