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- Dahlgren, Jovanna, 1964
(author)
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Easypod: a new electronic injection device for growth hormone
- 2008
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In: Expert Review of Medical Devices. - : Informa UK Limited. - 1743-4440 .- 1745-2422. ; 5:3, s. 297-304
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Journal article (peer-reviewed)abstract
- The easypod is the first automated electronic injection device for growth hormone delivery. To save user's time and reduce administration error, the dose is preset by a physician or nurse; in addition, to allow patient adherence to be monitored, the time, date and dose (mg) of each injection is recorded. Details of the last injection and number of doses remaining in the cartridge are also displayed in order to help patients manage the injection schedule. Drug use can be optimized by splitting the dose over two cartridges, with an automatic compensation facility to avoid under-dosing. Patients can customize the depth, speed and duration of the injection. In a user trial, easypod was very well accepted. This review places easypod in the context of current and future growth hormone devices.
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| 3. |
- Robinson, Yohan, 1977, et al.
(author)
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Evidence supporting the use of bone morphogenetic proteins for spinal fusion surgery.
- 2008
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In: Expert review of medical devices. - : Informa UK Limited. - 1743-4440 .- 1745-2422. ; 5:1, s. 75-84
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Research review (peer-reviewed)abstract
- Bone morphogenetic proteins (BMPs) are capable of promoting bone healing and even induce de novo osteogenesis. Their clinical application in spinal fusion surgery has recently increased in popularity. This is especially true for the use of BMPs in combination with artificial bone substitutes that have the capability to replace autologous bone graft, which can be associated with severe harvesting complications. This review will examine the use of BMP-2 and BMP-7 as commercially available products that have proven their osteoinductive capacity in spinal fusion. We will perform an overview of the literature for scientific evidence supporting the use of these new technologies. Despite their high osteoinductive potency, the use of BMPs does not replace proper surgical stabilization in spinal fusion. Safety issues with BMPs are osteoclast activation, postoperative swelling and hyperostosis. Despite these issues, manufacturers continue to expend more effort concerning proper application, dosage and carriers for these devices for spinal fusion, both presently and in the future.
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