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1.	Jovic, Sandra, et al. (author) Osteopontin is increased in cystic fibrosis and can skew the functional balance between ELR-positive and ELR-negative CXC-chemokines. 2015 In: Journal of Cystic Fibrosis. - : Elsevier BV. - 1873-5010 .- 1569-1993. ; 14:4, s. 453-463 Journal article (peer-reviewed)abstract The glycoprotein osteopontin plays important roles in several states of disease associated with inflammation, for example by recruiting neutrophils but its expression and possible roles in cystic fibrosis (CF) have not been investigated.
2.	Paulsson, Magnus, et al. (author) Identification of outer membrane Porin D as a vitronectin-binding factor in cystic fibrosis clinical isolates of Pseudomonas aeruginosa. 2015 In: Journal of Cystic Fibrosis. - : Elsevier BV. - 1873-5010 .- 1569-1993. ; 14:5, s. 600-607 Journal article (peer-reviewed)abstract Pseudomonas aeruginosa is a pathogen that frequently colonizes patients with cystic fibrosis (CF) or chronic obstructive pulmonary disease (COPD). Several pathogens are known to bind vitronectin to increase their virulence. Vitronectin has been shown to enhance P. aeruginosa adhesion to host epithelial cells.
3.	Qvist, Tavs, et al. (author) Epidemiology of nontuberculous mycobacteria among patients with cystic fibrosis in Scandinavia 2015 In: Journal of Cystic Fibrosis. - : Elsevier BV. - 1569-1993 .- 1873-5010. ; 14:1, s. 46-52 Journal article (peer-reviewed)abstract Background: Nontuberculous mycobacteria (NTM) are an emerging threat to cystic fibrosis (CF) patients but their epidemiology is not well described. Methods: In this retrospective observational study we identified all Scandinavian CF patients with a positive NTM culture from airway secretions from 2000 to the end of 2012 and used national CF databases to describe microbiological and clinical characteristics. Results: During the 13-year period 157 (11%) CF patients were culture positive for NTM at least once. Mycobacterium abscessus complex (MABSC) (45%) and Mycobacterium avium complex (MAC) (32%) were the predominant species with geographical differences in distribution. Younger patients were more prone to MABSC (p < 0.01). Despite treatment, less than one-third of MABSC patients with repeated positive cultures cleared their infection and a quarter had a lung transplant or died. Conclusion: NTM are significant CF pathogens and are becoming. more prevalent in Scandinavia. MABSC and MAC appear to target distinct patient groups. Having multiple positive cultures despite treatment conveys a poor outcome. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Mörgelin, Matthias (1); Erjefält, Jonas (1); Singh, Birendra (1); Riesbeck, Kristian (1); Egesten, Arne (1); Kjellström, Sven (1); show more...; Jovic, Sandra (1); Shikhagaie, Medya (1); Hansson, Lennart (1); Jonsson, Bodil (1); Hoiby, Niels (1); Paulsson, Magnus (1); Pressler, Tania (1); Høiby, Niels (1); Su, Yu Ching (1); Gilljam, Marita (1); Hollsing, Annika (1); Taylor-Robinson, Dav ... (1); Wang, Mikala (1); Katzenstein, Terese ... (1); Svahn, Anita (1); Tamim, Al-Jubair (1); Qvist, Tavs (1); Jensen-Fangel, Soren (1); Kotz, Karsten (1); Hansen, Christine R. (1); Finstad, Pal L. (1); show less...

University: Lund University (3); Uppsala University (1); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

Year: 2015 (3)

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