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Träfflista för sökning "L773:1932 7420 OR L773:1550 4131 srt2:(2015-2019)"

Search: L773:1932 7420 OR L773:1550 4131 > (2015-2019)

  • Result 1-10 of 81
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  • Balaz, M., et al. (author)
  • Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
  • 2019
  • In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 29:4
  • Journal article (peer-reviewed)abstract
    • Recent research focusing on brown adipose tissue (BAT) function emphasizes its importance in systemic metabolic homeostasis. We show here that genetic and pharmacological inhibition of the mevalonate pathway leads to reduced human and mouse brown adipocyte function in vitro and impaired adipose tissue browning in vivo. A retrospective analysis of a large patient cohort suggests an inverse correlation between statin use and active BAT in humans, while we show in a prospective clinical trial that fluvastatin reduces thermogenic gene expression in human BAT. We identify geranylgeranyl pyrophosphate as the key mevalonate pathway intermediate driving adipocyte browning in vitro and in vivo, whose effects are mediated by geranylgeranyltransferases (GGTases), enzymes catalyzing geranylgeranylation of small GTP-binding proteins, thereby regulating YAP1/TAZ signaling through F-actin modulation. Conversely, adipocyte-specific ablation of GGTase I leads to impaired adipocyte browning, reduced energy expenditure, and glucose intolerance under obesogenic conditions, highlighting the importance of this pathway in modulating brown adipocyte functionality and systemic metabolism.
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  • Caesar, Robert, 1973, et al. (author)
  • Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling
  • 2015
  • In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 22:4, s. 658-668
  • Journal article (peer-reviewed)abstract
    • Dietary lipids may influence the abundance of circulating inflammatory microbial factors. Hence, inflammation in white adipose tissue (WAT) induced by dietary lipids may be partly dependent on their interaction with the gut microbiota. Here, we show that mice fed lard for 11 weeks have increased Toll-like receptor (TLR) activation and WAT inflammation and reduced insulin sensitivity compared with mice fed fish oil and that phenotypic differences between the dietary groups can be partly attributed to differences in microbiota composition. Trif-/- and Myd88-/- mice are protected against lard-induced WAT inflammation and impaired insulin sensitivity. Experiments in germ-free mice show that an interaction between gut microbiota and saturated lipids promotes WAT inflammation independent of adiposity. Finally, we demonstrate that the chemokine CCL2 contributes to microbiota-induced WAT inflammation in lard-fed mice. These results indicate that gut microbiota exacerbates metabolic inflammation through TLR signaling upon challenge with a diet rich in saturated lipids. © 2015 The Authors.
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  • Cannon, Barbara, et al. (author)
  • What Ignites UCP1?
  • 2017
  • In: Cell Metabolism. - : Elsevier BV. - 1550-4131 .- 1932-7420. ; 26:5, s. 697-698
  • Journal article (other academic/artistic)abstract
    • We thought we knew how the heat-producing uncoupling protein 1 in brown adipose tissue was activated: by fatty acids released upon lipid droplet breakdown in the brown adipocytes. However, two studies in this issue (Schreiber et al., 2017; Shin et al., 2017) imply that this classical model may not be valid: heat can be produced in brown fat without intracellular lipolysis.
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  • Result 1-10 of 81
Type of publication
journal article (78)
research review (3)
Type of content
peer-reviewed (78)
other academic/artistic (3)
Author/Editor
Zierath, JR (10)
Bäckhed, Fredrik, 19 ... (9)
Kovatcheva-Datchary, ... (6)
Nielsen, Jens B, 196 ... (5)
Mardinoglu, Adil, 19 ... (5)
Kroemer, G (4)
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Groop, Leif (4)
Borén, Jan, 1963 (4)
Smith, Ulf, 1943 (4)
Berggren, PO (3)
Madeo, F (3)
Larsson, NG (3)
Ståhlman, Marcus, 19 ... (3)
Laakso, M. (3)
Clement, K (3)
Wang, Liya (3)
Marschall, Hanns-Ulr ... (2)
Uhlén, Mathias (2)
Lee, Sunjae (2)
Tremaroli, Valentina ... (2)
Abdulreda, MH (2)
Caicedo, A (2)
Rodriguez-Diaz, R (2)
Renström, Erik (2)
Zhang, C. (2)
Tarasov, A. I. (2)
Rorsman, Patrik, 195 ... (2)
Mulder, Hindrik (2)
Björnson, Elias, 198 ... (2)
Saghatelian, Alan (2)
Barres, R (2)
Ferrannini, E (2)
Cao, YH (2)
Enerbäck, Sven, 1958 (2)
Cedernaes, Jonathan (2)
Asplund, Olof (2)
Bluher, M. (2)
Piening, B. D. (2)
Kauppila, TES (2)
Groen, A. K. (2)
Zhang, Enming (2)
Milenkovic, D. (2)
Serlie, M. J. (2)
Hofer, SJ (2)
Bass, Joseph (2)
Ramsey, Kathryn Moyn ... (2)
Kobayashi, Yumiko (2)
Peek, Clara Bien (2)
Levine, Daniel C. (2)
Snyder, M (2)
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University
Karolinska Institutet (42)
University of Gothenburg (20)
Lund University (9)
Chalmers University of Technology (8)
Royal Institute of Technology (7)
Uppsala University (7)
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Swedish University of Agricultural Sciences (4)
Stockholm University (2)
Örebro University (1)
Linköping University (1)
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Language
English (81)
Research subject (UKÄ/SCB)
Medical and Health Sciences (37)
Natural sciences (18)
Agricultural Sciences (2)

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