↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "L773:2296 5270 OR L773:2296 5262 srt2:(2014)"

Search: L773:2296 5270 OR L773:2296 5262 > (2014)

Result 1-5 of 5

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Bernhard, Juerg, et al. (author) Clinical Benefit Response in Pancreatic Cancer Trials Revisited 2014 In: Oncology Research and Treatment. - : S. Karger AG. - 2296-5270 .- 2296-5262. ; 37:1-2, s. 42-48 Journal article (peer-reviewed)abstract Objectives: Clinical benefit response (CBR), based on changes in pain, Karnofsky performance status, and weight, is an established palliative endpoint in trials for advanced gastrointestinal cancer. We investigated whether CBR is associated with survival, and whether CBR reflects a wide-enough range of domains to adequately capture patients' perception. Methods: CBR was prospectively evaluated in an international phase III chemotherapy trial in patients with advanced pancreatic cancer (n = 311) in parallel with patient-reported outcomes (PROs). Results: The median time to treatment failure was 3.4 months (range: 0-6). The majority of the CBRs (n = 39) were noted in patients who received chemotherapy for at least 5 months. Patients with CBR (n = 62) had longer survival than non-responders (n = 182) (hazard ratio = 0.69; 95% confidence interval: 0.51-0.94; p = 0.013). CBR was predicted with a sensitivity and specificity of 77-80% by various combinations of 3 mainly physical PROs. A comparison between the duration of CBR (n = 62, median = 8 months, range = 4-31) and clinically meaningful improvements in the PROs (n = 100-116; medians = 9-11 months, range = 4-24) showed similar intervals. Conclusion: CBR is associated with survival and mainly reflects physical domains. Within phase III chemotherapy trials for advanced gastrointestinal cancer, CBR can be replaced by a PRO evaluation, without losing substantial information but gaining complementary information.
2.	Kumar, A. Vijaya, et al. (author) HS3ST2 modulates breast cancer cell invasiveness and chemosensitivity via MAP kinase- and TCF7L2/TCF4-dependent regulation of protease and cadherin expression 2014 In: Oncology Research and Treatment. - 2296-5270 .- 2296-5262. ; 37:S1, s. 95-95 Journal article (other academic/artistic)
3.	Öberg, Kjell (author) Treatment of high-grade neuroendocrine tumors beyond platinum/etoposide 2014 In: Oncology Research and Treatment. - 2296-5270 .- 2296-5262. ; 37:5, s. 297-298 Journal article (other academic/artistic)
4.	Oing, C, et al. (author) Impact of bone metastases at initial diagnosis in male patients with metastatic germ cell tumors: Results from an international database 2014 In: ONCOLOGY RESEARCH AND TREATMENT. - 2296-5270. ; 37, s. 2-4 Conference paper (other academic/artistic)
5.	Seeber, A, et al. (author) Detection of soluble EpCAM in malignant-releated ascites neutralize the effect of Catumaxomab in vitro and in vivo 2014 In: ONCOLOGY RESEARCH AND TREATMENT. - 2296-5270. ; 37, s. 154-154 Conference paper (other academic/artistic)

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-5 of 5

Refine your search

Type of publication: journal article (3); conference paper (2)

Type of content: other academic/artistic (4); peer-reviewed (1)

Author/Editor: Bokemeyer, C (1); Glimelius, Bengt (1); Sehouli, J (1); Öberg, Kjell (1); Fiegl, H (1); Cohn-Cedermark, G (1); show more...; Spizzo, G. (1); Kiesel, L (1); Fedyanin, M (1); Loriot, Y (1); Flechon, A (1); Oechsle, K (1); Daugaard, G (1); Dietrich, Daniel (1); Scheithauer, Werner (1); Herrmann, Richard (1); Bernhard, Juerg (1); Bodoky, Gyoergy (1); De Giorgi, U. (1); Hentrich, M. (1); Lorch, A. (1); Necchi, A. (1); Oing, C (1); Sava, T (1); Steiner, N. (1); Kumar, A. Vijaya (1); Gassar, E. Salem (1); Spillmann, Dorthoe (1); Huelsewig, C. (1); Stock, C. (1); Yip, G. W. (1); Goette, M. (1); Gastl, G (1); Martowicz, A (1); Untergasser, G (1); Seeber, A (1); Winquist, E (1); Fare, E (1); Gietema, J (1); Fong, D (1); Braicu, I (1); Nassir, M (1); Botta, L (1); Schulze, E (1); Zeimet, A (1); show less...

University: Uppsala University (3); Karolinska Institutet (2)

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2014 (5)Undo refine

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view