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Träfflista för sökning "WFRF:(Åberg Fredrik) "

Search: WFRF:(Åberg Fredrik)

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1.
  • Alvez, Maria Bueno, et al. (author)
  • Next generation pan-cancer blood proteome profiling using proximity extension assay
  • 2023
  • In: Nature Communications. - : Springer Nature. - 2041-1723. ; 14:1
  • Journal article (peer-reviewed)abstract
    • A comprehensive characterization of blood proteome profiles in cancer patients can contribute to a better understanding of the disease etiology, resulting in earlier diagnosis, risk stratification and better monitoring of the different cancer subtypes. Here, we describe the use of next generation protein profiling to explore the proteome signature in blood across patients representing many of the major cancer types. Plasma profiles of 1463 proteins from more than 1400 cancer patients are measured in minute amounts of blood collected at the time of diagnosis and before treatment. An open access Disease Blood Atlas resource allows the exploration of the individual protein profiles in blood collected from the individual cancer patients. We also present studies in which classification models based on machine learning have been used for the identification of a set of proteins associated with each of the analyzed cancers. The implication for cancer precision medicine of next generation plasma profiling is discussed.
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  • Willgren, David, et al. (author)
  • Adventsuppropet problematiskt
  • 2012
  • In: Dagen. - 1652-5264.
  • Journal article (pop. science, debate, etc.)abstract
    • "Vi har problem med Adventsuppropet och den privilegierade ställning som den kristna tron förutsätts ha i det, skriver 18 pastorer och församlingsledare."
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  • Åberg, N David, 1970, et al. (author)
  • Insulin-like growth factor-I increases astrocyte intercellular gap junctional communication and connexin43 expression in vitro.
  • 2003
  • In: Journal of neuroscience research. - : Wiley. - 0360-4012. ; 74:1, s. 12-22
  • Journal article (peer-reviewed)abstract
    • Connexin43 (cx43) forms gap junctions in astrocytes, and these gap junctions mediate intercellular communication by providing transport of low-molecular-weight metabolites and ions. We have recently shown that systemic growth hormone increases cx43 in the brain. One possibility was that local brain insulin-like growth factor-I (IGF-I) could mediate the effect by acting directly on astrocytes. In the present study, we examined the effects of direct application of recombinant human IGF-I (rhIGF-I) on astrocytes in primary culture concerning cx43 protein expression and gap junctional communication (GJC). After 24 hr of stimulation with rhIGF-I under serum-free conditions, the GJC and cx43 protein were analyzed. Administration of 30 ng/ml rhIGF-I increased the GJC and the abundance of cx43 protein. Cell proliferation of the astrocytes was not significantly increased by rhIGF-I at this concentration. However, a higher concentration of rhIGF-I (150 ng/ml) had no effect on GJC/cx43 but increased cell proliferation. Because of the important modulatory role of IGF binding proteins (IGFBPs) on IGF-I action, we analyzed IGFBPs in conditioned media. In cultures with a low abundance of IGFBPs (especially IGFBP-2), the GJC response to 30 ng/ml rhIGF-I was 81%, compared with the average of 25%. Finally, as a control, insulin was given in equimolar concentrations. However, GJC was not affected, which suggests that rhIGF-I acted via IGF-I receptors. In summary, the data show that rhIGF-I may increase GJC/cx43, whereas a higher concentration of rhIGF-I--at which stimulation of proliferation occurred--did not affect GJC/cx43. Furthermore, IGFBP-2 appeared to modulate the action of rhIGF-I on GJC in astrocytes by a paracrine mechanism.
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7.
  • Åberg, Veronica, 1976-, et al. (author)
  • Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of A beta-peptide aggregation inhibitors
  • 2005
  • In: Organic and biomolecular chemistry. - London, U.K. : Royal Society of Chemistry. - 1477-0520 .- 1477-0539. ; 3:15, s. 2817-2823
  • Journal article (peer-reviewed)abstract
    • A reagent-free microwave-assisted decarboxylation procedure for carboxylic acid functionalized bicyclic 2-pyridones has been developed. This new method, based on microwave heating at 220 degrees C for 600 seconds in N-methyl pyrrolidone (NMP), proved to be practical and very efficient, resulting in decarboxylated 2-pyridones in near-quantitative yields. The decarboxylated products and the intermediate 2-pyridones in the form of carboxylic acid methyl esters and carboxylic acids were screened for their effect on A beta-peptide aggregation. Two out of the 21 2-pyridones described in this study inhibited amyloid formation of the Alzheimer A beta(1-40) peptide. The effect was seen even at a 4 : 1 ratio of 2-pyridone and monomeric A beta-peptide.
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  • Åkerfeldt, Anna, et al. (author)
  • "Fridolin backar in i framtiden om digitala läromedel"
  • 2021
  • In: Dagens Nyheter. - 1101-2447. ; :2021-12-16
  • Journal article (pop. science, debate, etc.)abstract
    • Ingress: 23 forskare inom it- och utbildningsområdet: Regeringens utredare borde inte lyfta fram läsning på skärm som något negativt.Forskning ­visar att både tryckta och digitala läromedel behövs i skolan.
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  • Result 1-10 of 64
Type of publication
journal article (48)
doctoral thesis (6)
other publication (4)
conference paper (3)
reports (1)
research review (1)
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licentiate thesis (1)
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Type of content
peer-reviewed (44)
other academic/artistic (16)
pop. science, debate, etc. (4)
Author/Editor
Almqvist, Fredrik (12)
Hultgren, Scott J (7)
Åberg, Mikael (6)
Lernmark, Åke (5)
Ramelius, Anita (5)
Ask, Maria (5)
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Lundgren, Markus (5)
Jonsdottir, Berglind (5)
Törn, Carina (5)
Hedenström, Mattias (5)
Agardh, Daniel (4)
Cilio, Corrado (4)
Vessby, Johan, 1972- (4)
Rorsman, Fredrik, Do ... (4)
Åberg, Anna Cristina (4)
Halvorsen, Kjartan (4)
Nouri, Jalal (3)
Mardinoglu, Adil (3)
Rönnbäck, Lars, 1951 (3)
Edfors, Fredrik (3)
Castedal, Maria, 196 ... (3)
Olsson, Fredrik (3)
Andersson, Per (3)
Andrén Aronsson, Car ... (3)
Viberg, Olga (3)
Hammarström, Per (3)
Toppari, Jorma (3)
Willgren, David (3)
Wenell, Fredrik (3)
Melin, Jonas (3)
Nilsson, Pernilla (3)
Säljö, Roger (3)
Liu, Xiang (3)
Carlson, Marie, 1957 ... (3)
Selander, Staffan (3)
Eriksson, Peter S, 1 ... (3)
Grönlund, Åke (3)
Elding Larsson, Hele ... (3)
Josefsson, Pernilla (3)
Pemberton, Nils (3)
She, Jin Xiong (3)
Ziegler, Anette G. (3)
Akolkar, Beena (3)
Vehik, Kendra (3)
Åberg, N David, 1970 (3)
Arvidsson, Thomas (3)
Godhe, Anna-Lena (3)
Lindberg, Ylva (3)
Norén, Eva (3)
Giedraitis, Vilmanta ... (3)
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University
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University of Gothenburg (12)
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Högskolan Dalarna (4)
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Kristianstad University College (2)
University of Gävle (2)
The Swedish School of Sport and Health Sciences (2)
Halmstad University (1)
University West (1)
Jönköping University (1)
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Chalmers University of Technology (1)
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Language
English (53)
Swedish (9)
Undefined language (2)
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Medical and Health Sciences (34)
Natural sciences (7)
Humanities (7)
Social Sciences (5)
Engineering and Technology (2)

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