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- Venetsanos, Dimitrios, et al.
(author)
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Sex-related response to bivalirudin and unfractionated heparin in patients with acute myocardial infarction undergoing percutaneous coronary intervention : A subgroup analysis of the VALIDATE-SWEDEHEART trial
- 2019
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In: European Heart Journal. - : Sage Publications. - 2048-8726 .- 2048-8734. ; 8:6, s. 502-509
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Journal article (peer-reviewed)abstract
- AIMS: Our aim was to study the impact of sex on anticoagulant treatment outcomes during percutaneous coronary intervention in acute myocardial infarction patients.METHODS: This study was a prespecified analysis of the Bivalirudin versus Heparin in ST-Segment and Non ST-Segment Elevation Myocardial Infarction in Patients on Modern Antiplatelet Therapy in the Swedish Web System for Enhancement and Development of Evidence-based Care in Heart Disease Evaluated according to Recommended Therapies Registry Trial (VALIDATE-SWEDEHEART) trial, in which patients with myocardial infarction were randomised to bivalirudin or unfractionated heparin during percutaneous coronary intervention. The primary outcome was the composite of death, myocardial infarction or major bleeding at 180 days.RESULTS: There was a lower risk of the primary outcome in women assigned to bivalirudin than to unfractionated heparin (13.6% vs 17.1%, hazard ratio 0.78, 95% confidence interval (0.60-1.00)) with no significant difference in men (11.8% vs 11.2%, hazard ratio 1.06 (0.89-1.26), p for interaction 0.05). The observed difference was primarily due to lower risk of major bleeding (Bleeding Academic Research Consortium definition 2, 3 or 5) associated with bivalirudin in women (8.9% vs 11.8%, hazard ratio 0.74 (0.54-1.01)) but not in men (8.5% vs 7.3%, hazard ratio 1.16 (0.94-1.43) in men, p for interaction 0.02). Conversely, no significant difference in the risk of Bleeding Academic Research Consortium 3 or 5 bleeding, associated with bivalirudin, was found in women 4.5% vs 5.4% (hazard ratio 0.84 (0.54-1.31)) or men 2.9% vs 2.1% (hazard ratio 1.36 (0.93-1.99)). Bleeding Academic Research Consortium 2 bleeding occurred significantly less often in women assigned to bivalirudin than to unfractionated heparin. The risk of death or myocardial infarction did not significantly differ between randomised treatments in men or women.CONCLUSION: In women, bivalirudin was associated with a lower risk of adverse outcomes, compared to unfractionated heparin, primarily due to a significant reduction in Bleeding Academic Research Consortium 2 bleeds.
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- Agostoni, C, et al.
(author)
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Enteral nutrient supply for preterm infants : commentary from the European society of paediatric gastroenterology, hepatology and nutrition committee on nutrition
- 2010
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In: Journal of Pediatric Gastroenterology and Nutrition - JPGN. - New York : Raven P.. - 0277-2116 .- 1536-4801. ; 50:1, s. 85-91
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Journal article (peer-reviewed)abstract
- The number of surviving children born prematurely has increased substantially during the last 2 decades. The major goal of enteral nutrient supply to these infants is to achieve growth similar to foetal growth coupled with satisfactory functional development. The accumulation of knowledge since the previous guideline on nutrition of preterm infants from the Committee on Nutrition of the European Society of Paediatric Gastroenterology and Nutrition in 1987 has made a new guideline necessary. Thus, an ad hoc expert panel was convened by the Committee on Nutrition of the European Society of Paediatric Gastroenterology, Hepatology, and Nutrition in 2007 to make appropriate recommendations. The present guideline, of which the major recommendations are summarised here (for the full report, see http://links.lww.com/A1480), is consistent with, but not identical to, recent guidelines from the Life Sciences Research Office of the American Society for Nutritional Sciences published in 2002 and recommendations from the handbook Nutrition of the Preterm Infant. Scientific Basis and Practical Guidelines, 2nd ed, edited by Tsang et al, and published in 2005. The preferred food for premature infants is fortified human milk from the infant's own mother, or, alternatively, formula designed for premature infants. This guideline aims to provide proposed advisable ranges for nutrient intakes for stable-growing preterm infants up to a weight of approximately 1800 g, because most data are available for these infants. These recommendations are based on a considered review of available scientific reports on the subject, and on expert consensus for which the available scientific data are considered inadequate.
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- Aggestål, Anna, et al.
(author)
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Managing Sport for Public Health : Approaching Contemporary Problems with Traditional Solutions
- 2015
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In: Social Inclusion. - Lisbon : Cogitatio. - 2183-2803. ; 3:3, s. 108-117
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Journal article (peer-reviewed)abstract
- In the area of public health, civil society involvement in attaining government objectives on physical activity participation is often carried out by voluntary sport organizations (Agergaard & Michelsen la Cour, 2012; Österlind & Wright, 2014; Skille, 2009; Theeboom, Haudenhuyse, & De Knop, 2010). In Sweden, this responsibility has been given to the Swedish Sport Confederation (SSC), a voluntary and membership-based non-profit organization, granted government authority to govern Swedish sport towards government objectives (Bergsgard & Norberg, 2010; Bolling, 2005). Research has pointed to difficulties for sport organizations to shoulder such responsibilities due to the deeply rooted logic of competition in sport and organizational structures adapted for competitive sport (Skille, 2011; Stenling & Fahlén, 2009). This article focuses on how public health is being constructed, implemented and given meaning within the SSC. Drawing on a critical discourse approach (Fairclough & Fairclough, 2012) this study explores the SSC’s role and position in public health promotion by interviewing SSC representatives and National Sport Organizations’ (NSO) general managers. Results indicate how discourses on democracy, equality and physical activity are used to legitimize the SSC’s role in public health. Also, how these discourses are compromised in practice, posing challenges for organized sport in meeting objectives of public health.
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| 9. |
- Aggestål, Anna, 1969-
(author)
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The role of voluntary sports organisations in delivering physical activity on prescription (PAOP) : the case of Sweden
- 2019
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In: Book of Abstracts. - Prague : Charles University, 2019.
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Conference paper (peer-reviewed)abstract
- Globally, public health is a political priority with governments´ increasingly supporting interventions in civil society for reaching health related objectives. There is a worldwide public health focus on increasing population levels of physical activity by prescribing exercise as a preventive strategy against the risk of developing a range of non-communicable diseases. The employment of voluntary sports organisations is increasingly becoming the mechanism for physical activity promotion and the implementation of interventions to raise physical activity levels. This study explores the Swedish Sports Confederation´s (SSC) implementation of physical activity on prescription (PAOP). While studies exist about the effectiveness of exercise referral schemes and programs, for participant adherence, increasing physical activity, fitness or health indicators, knowledge about the role of different organisations in delivering such schemes has been called for. In heeding this call, this study interviewed representatives from the 21 Regional Sports Federations in Sweden involved in leading, organizing and delivering physical activity. The results of the interviewee data provide detail on how PAOP is delivered and received. The presentation summarizes the findings and illustrates the complex barriers and facilitators involved in stimulating and engaging previously inactive participants in sustained physical activity in the Swedish Sports Confederation system.
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