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Träfflista för sökning "WFRF:(Ai M) srt2:(1995-1999)"

Sökning: WFRF:(Ai M) > (1995-1999)

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  • Andre, M, et al. (författare)
  • Ion energization mechanisms at 1700 km in the auroral region
  • 1998
  • Ingår i: JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. - : AMER GEOPHYSICAL UNION. ; 103:A3, s. 4199-4222
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Observations obtained by the Freja satellite at altitudes around 1700 km in the high-latitude magnetosphere are used to study ion energization perpendicular to the geomagnetic field. Investigations of ions, electrons, plasma densities, electric and magnet
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  • Djerbi, M, et al. (författare)
  • The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors
  • 1999
  • Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 190:7, s. 1025-1031
  • Tidskriftsartikel (refereegranskat)abstract
    • Death receptor–mediated apoptosis can be modulated by several antiapoptotic proteins, such as the FLICE (FADD [Fas-associated death domain]-like IL-1β–converting enzyme)-inhibitory proteins (FLIPs). The FLIP family includes both cellular and viral members. The Kaposi's sarcoma–associated herpesvirus protein (KSHV)-FLIP is expressed by human herpesvirus 8 (HHV-8), which is associated with malignancies such as Kaposi's sarcoma and certain lymphomas. In this paper, we demonstrate that KSHV-FLIP protects cells from Fas-mediated apoptosis by inhibiting caspase activation and permits clonal growth in the presence of death stimuli in vitro. Furthermore, we show that KSHV-FLIP can act as a tumor progression factor by promoting tumor establishment and growth in vivo. When injected into immunocompetent recipient mouse strains, murine B lymphoma cells (A20) transduced with KSHV-FLIP rapidly develop into aggressive tumors showing a high rate of survival and growth. The tumor-progressive activity of KSHV-FLIP is mediated by prevention of death receptor–induced apoptosis triggered by conventional T cells. Consequently, inhibitors of death receptor signaling can be regarded as a new class of tumor progression factors, and HHV-8–associated tumors may represent naturally occurring examples of the tumorigenic effect of such inhibitors.
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  • Dovner, PO, et al. (författare)
  • The occurrence of lower hybrid cavities in the upper ionosphere
  • 1997
  • Ingår i: GEOPHYSICAL RESEARCH LETTERS. - : AMER GEOPHYSICAL UNION. - 0094-8276. ; 24:5, s. 619-622
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • Lower hybrid cavities (LHC), i. e., small-scale density depletions coinciding with enhanced lower hybrid waves, are frequent in the upper ionosphere. It is found that they exist in all regions the Freja satellite has scanned, as long as lower hybrid waves
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  • Resultat 1-10 av 14

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