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- Akdeniz, B Güniz, et al.
(author)
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Effect of delayed scanning of storage phosphor plates.
- 2005
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In: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. - : Elsevier BV. - 1528-395X .- 1079-2104. ; 99:5, s. 603-7
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To test longevity of image quality in storage phosphor plates (SPPs) at various exposure settings, storage conditions, and delays in scanning. STUDY DESIGN: Fifteen Digora plates were exposed from 0.08 to 0.20 seconds and scanned immediately, 10, 30, and 60 minutes, and 24 hours after exposure. Plates were stored both in daylight and in a light-tight box. Mean gray values (MGVs) were compared using 2 x 5 x 5 factorial ANOVA. Interaction between variables was tested using Bonferroni/Dunn multiple comparisons test. RESULTS: MGVs decreased with increase in exposure but increased with the scan delay. Only MGVs of plates scanned within 10 minutes after exposure were not significantly different from the ones scanned immediately ( P > .05). MGVs increased with scan delay for all exposure times no matter how the plates were stored ( P < .05). CONCLUSION: Based on the time delays examined, it is recommended to scan the Digora SPP no later than 10 minutes after exposure. Longer periods may cause loss of quality.
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- Damato, V, et al.
(author)
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Rituximab abrogates aquaporin-4-specific germinal center activity in patients with neuromyelitis optica spectrum disorders
- 2022
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 119:24, s. e2121804119-
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Journal article (peer-reviewed)abstract
- By studying paired blood and deep cervical lymph node samples from patients with neuromyelitis optica spectrum disorders, our data provide evidence for a germinal center–based generation of aquaporin-4 antibodies. Frequent serum aquaporin-4 immunoglobulin Ms (IgMs) and shifts in IgG subclasses were observed alongside preferential synthesis of aquaporin-4 IgGs and aquaporin-4–reactive B cells within lymph nodes. Both intranodal synthesis of aquaporin-4 antibodies and intranodal aquaporin-4–reactive B cells were robustly eliminated with rituximab administration. This study systematically explores lymph nodes that drain the central nervous system (CNS) in patients with CNS autoimmunity and offers a potential explanation as to why rituximab is clinically highly efficacious in autoantibody-mediated diseases despite no accompanying reduction in serum autoantibody levels.
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