| 1. |
- Abdesselam, A., et al.
(author)
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Engineering for the ATLAS SemiConductor Tracker (SCT) end-cap
- 2008
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In: Journal of Instrumentation. - 1748-0221. ; 3
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Journal article (peer-reviewed)abstract
- The ATLAS SemiConductor Tracker (SCT) is a silicon-strip tracking detector which forms part of the ATLAS inner detector. The SCT is designed to track charged particles produced in proton-proton collisions at the Large Hadron Collider (LHC) at CERN at an energy of 14 TeV. The tracker is made up of a central barrel and two identical end-caps. The barrel contains 2112 silicon modules, while each end-cap contains 988 modules. The overall tracking performance depends not only on the intrinsic measurement precision of the modules but also on the characteristics of the whole assembly, in particular, the stability and the total material budget. This paper describes the engineering design and construction of the SCT end-caps, which are required to support mechanically the silicon modules, supply services to them and provide a suitable environment within the inner detector. Critical engineering choices are highlighted and innovative solutions are presented - these will be of interest to other builders of large-scale tracking detectors. The SCT end-caps will be fully connected at the start of 2008. Further commissioning will continue, to be ready for proton-proton collision data in 2008.
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| 2. |
- Clark, Andrew G., et al.
(author)
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Evolution of genes and genomes on the Drosophila phylogeny
- 2007
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 450:7167, s. 203-218
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Journal article (peer-reviewed)abstract
- Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species.
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| 3. |
- Lindblad-Toh, Kerstin, et al.
(author)
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Genome sequence, comparative analysis and haplotype structure of the domestic dog.
- 2005
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 438:7069, s. 803-19
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Journal article (peer-reviewed)abstract
- Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.
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| 4. |
- Rich, Rebecca L., et al.
(author)
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A global benchmark study using affinity-based biosensors
- 2009
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In: Analytical Biochemistry. - : Elsevier BV. - 0003-2697 .- 1096-0309. ; 386:2, s. 194-216
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Journal article (peer-reviewed)abstract
- To explore the variability in biosensor studies, 150 participants from 20 countries were given the same protein samples and asked to determine kinetic rate constants for the interaction. We chose a protein system that was amenable to analysis using different biosensor platforms as well as by users of different expertise levels. The two proteins (a 50-kDa Fab and a 60-kDa glutathione S-transferase [GST] antigen) form a relatively high-affinity complex, so participants needed to optimize several experimental parameters, including ligand immobilization and regeneration conditions as well as analyte concentrations and injection/dissociation times. Although most participants collected binding responses that could be fit to yield kinetic parameters, the quality of a few data sets could have been improved by optimizing the assay design. Once these outliers were removed, the average reported affinity across the remaining panel of participants was 620 pM with a standard deviation of 980 pM. These results demonstrate that when this biosensor assay was designed and executed appropriately, the reported rate constants were consistent, and independent of which protein was immobilized and which biosensor was used.
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| 5. |
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| 6. |
- Anderson, John B
(author)
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Digital Transmission Engineering
- 2005
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Book (other academic/artistic)abstract
- This textbook is a 4th year(Sweden)/5th year (USA) text in digital communication theory and practice. Chapters include baseband pulse transmission, carrier transmission, synchronization, channels, coding and information theory, and advanced topics. Each chapter ends with 25 home exercises. Worked examples and Matlab tools are integrated with the text.
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| 7. |
- Anderson, John B, et al.
(author)
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New reduced state space BCJR algorithms for the ISI channel
- 2009
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In: Proceedings, International Symp. on Information Theory. - 9781424443130 ; , s. 889-893
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Conference paper (peer-reviewed)abstract
- A critical component in detection under intersymbol interference (ISI) and in turbo equalization is the BCJR algorithm. We study two approaches to reducing its computation. First, the state space is reduced by optimizing the receiver's phase-maximizing all pass filter. Then the state space used by the BCJR calculation is reduced by breaking the state into an offset and a main state. These procedures are demonstrated by ISI detection and turbo equalization over strongly bandlimited channels.
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| 8. |
- Anderson, John B, et al.
(author)
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On the BCJR algorithm for rate-distortion source coding
- 2007
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In: IEEE Transactions on Information Theory. - 0018-9448. ; 53:9, s. 3201-3207
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Journal article (peer-reviewed)abstract
- The BCJR algorithm is an important channel decoding method. We extend it to trellis rate-distortion data compression. Beginning from source coding principles, the derivation of the algorithm avoids channel coding or soft output ideas. The encoder does not use entropy coding; equiprobable reproducer letters are emphasized since these maximize entropy. The BCJR method is demonstrated by tests of a tailbiting variant. It performs much better than the ordinary Viterbi algorithm for short and medium blocks. However, the improvement stems from tailbiting; the role of the BCJR is to achieve tailbiting in a relatively simple way. Some issues that arise with tailbiting are explored. It is shown that there is an optimal trellis state size for each block length.
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| 9. |
- Anderson, John B, et al.
(author)
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On the BCJR algorithm for rate-distortion source coding
- 2005
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In: IEEE International Symposium on Information Theory - Proceedings. ; 2005, s. 1932-1936
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Conference paper (peer-reviewed)abstract
- The BCJR algorithm is an important method of channel decoding. We extend it here to rate-distortion encoding. The arguments begin from source coding principles and make no use of channel coding or soft output ideas. An important role is played by codeword ensembles with equiprobable reproducer letters. The BCJR method is demonstrated by tests of a tailbiting BCJR with the Gaussian source. The outcome improves Viterbi algorithm performance at short and medium blocklengths.
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| 10. |
- Anderson, John B, et al.
(author)
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Serial and parallel concatenations based on faster than Nyquist signaling
- 2006
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In: Proceedings, 2006 IEEE International Symposium on Information Theory. - 1424405041 ; , s. 1993-1997
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Conference paper (peer-reviewed)abstract
- We investigate the performance of concatenated coding schemes based on Faster Than Nyquist(FTN) signaling over the AWGN channel. We test both serial and parallel concatenations. In serial concatenation the FTN signaling is considered as the inner encoder and the outer code is a rate b/c convolutional code. In parallel schemes we use two parallel Gaussian channels and transmit FTN pulse trains in both; here a precoding device turns out to be crucial. The convergence behaviour is analysed using EXIT charts. The overall spectral density of the schemes varies but is roughly 1–2 bit/s/Hz. The results, in terms of needed Eb/N0 for reliable communication versus spectral density, are very good.
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