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- Agardh, Carl-David, et al.
(author)
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Lack of association between plasma homocysteine levels and microangiopathy in type 1 diabetes mellitus
- 1994
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In: Scandinavian Journal of Clinical & Laboratory Investigation. - : Informa UK Limited. - 1502-7686 .- 0036-5513. ; 54:8, s. 637-641
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Journal article (peer-reviewed)abstract
- The reactive vascular-injuring amino acid homocysteine was previously shown to be increased in plasma in diabetic patients with clinical signs of nephropathy. In this study, plasma homocysteine was measured in type 1 diabetic patients with normoalbuminuria (n = 22), microalbuminuria (n = 40) and proteinuria (n = 14) in order to investigate whether plasma homocysteine levels are increased already at the stage of incipient nephropathy, i.e. microalbuminuria. Furthermore, patients were characterized according to the degree of retinopathy. Plasma homocysteine in the whole population (n = 76) was related to B-Folate (r = 0.38, p < 0.01), S-Creatinine (r = 0.55, p < 0.001), S-Urea (r = 0.37, p < 0.01), U-Albumin (r = 0.46, p < 0.001), urinary N-acetyl-beta- glucosaminidase (r = 0.40, p < 0.001), systolic blood pressure (r = 0.36, p < 0.01) and diabetes duration (r = 0.44, p < 0.001). There were no differences in plasma homocysteine levels between patients with normoalbuminuria (8.0 +/- 1.7 mumol l-1; mean +/- SD) and those with microalbuminuria (9.1 +/- 3.4 mumol l-1). However, patients with clinical signs of nephropathy had higher plasma homocysteine levels (12.9 +/- 5.7 mumol l-1, p < 0.01) compared to the other two groups. There was no association between plasma homocysteine levels and different degrees of retinopathy. Thus, the present study does not show any relation between plasma homocysteine levels and early stages of diabetic nephropathy or retinopathy indicating that elevated concentrations of plasma homocysteine does not explain the increased risk for atherosclerosis observed in patients with microalbuminuria.
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| 5. |
- Andersson, K, et al.
(author)
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Hyperplasia of histaime-depleted enterochromaffin-like cells in rat stomach using omeprazole and a-fluoromethylhistidine
- 1992
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In: Gastroenterology. - 1528-0012. ; 103:3, s. 897-904
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Journal article (peer-reviewed)abstract
- In the rat, gastric histamine is stored mainly in the enterochromaffinlike cells. Gastrin releases histamine from these cells, and long-term hypergastrinemia results in hyperplasia. The effect of sustained hypergastrinemia on histamine-depleted enterochromaffinlike cells was studied by measuring histidine decarboxylase activity and histamine concentrations and by using quantitative histology. Hypergastrinemia maintained for 6 weeks was induced by inhibition of gastric acid secretion with omeprazole (400 mumol.kg-1.day-1) given orally, and histamine synthesis was inhibited for the same length of time with alpha-fluoromethylhistidine (3 mg.kg-1.h-1) given via osmotic minipumps. In rats given omeprazole alone, the effects of the resulting hypergastrinemia on the enterochromaffinlike cells was reflected in increased histidine decarboxylase activity, increased histamine concentration, and increased number of enterochromaffinlike cells. The general trophic effects on the stomach were seen as increased stomach and oxyntic mucosal weight and increased mucosal thickness. Treatment with alpha-fluoromethylhistidine plus omeprazole markedly reduced the histidine decarboxylase activity and histamine concentration, but the weight of the stomach and oxyntic mucosa, the enterochromaffinlike cell density, and intensity of histidine decarboxylase immunostaining were increased to at least the same extent as after omeprazole alone. These observations indicate that enterochromaffinlike cell histamine is not important for a full expression of gastrin-evoked trophic effects in the stomach.
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| 7. |
- Andersson, Maria, 1965-, et al.
(author)
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Cost-effective energy system measures studied by dynamic modelling
- 1993
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In: 2nd International Conference on Advances in Power System Control, Operation and Management, APSCOM-93.. - London : Institution of Electrical Engineers (IEE). - 0852965699 ; , s. 448-455
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Conference paper (peer-reviewed)abstract
- In a national electricity system there often exists a great potential for increasing the cost-efficiency of the electricity use. However, if the economic incentives for improving the use of the system are too weak, it is most likely that this potential will not be utilised. If electricity tariffs reflect real electricity costs, over the year and the day, cost-effective incentives will arise for introducing energy system measures that will reduce the energy system cost considerably. This paper presents two energy system analyses of an existing Swedish municipal energy system. The analyses are carried out with a simulation model for electricity use in industrial energy systems, and an optimisation model that is based on linear programming.<>
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| 8. |
- Andersson, Maria, 1965-
(author)
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Cost-effective incentives for local electric utilities and industries in co-operation : modelling of technical measures
- 1993
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Licentiate thesis (other academic/artistic)abstract
- In the Swedish electricity system there is a great potential for increasing the cost efficiency of the electricity use. However, today the economic incentives, offered for instance by existing electricity rates, are too weak to improve the use of the system. On the Swedish electricity market there are, at least, three different actors, the power producer, the distributor and the customer. Today these actors act separately due to low awareness of the costs for electricity generation, over the year and the day. If the actors are aware of the real electricity costs, cost-effective incentives will arise to introduce energy system measures that will reduce the energy system cost considerably. The thesis presents two energy system analyses of an existing Swedish municipality. The first analysis deals with the introduction of industrial end-use measures, with the local utility’s existing electricity rates as boundary conditions. The analysis is carried out with a simulation model for electricity use in industries. The second analysis deals with the introduction of energy system measures, on the municipal supply-side and demand-side, when the local electric utility and the customers are regarded as one system. The analysis is carried out with an optimization model, that is based on linear programming. The results show that if 17 industries introduce end-use measures, with the existing electricity rates as boundary conditions, their energy system costs will be reduced by 12 MSEK for a time period of 10 years, whereas the local utility will increase its energy system cost by 6 MSEK. However, if there is a co-operation between the local electric utility and the customers, their joint energy system cost will be reduced by 330 MSEK for a time period of 10 years.
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| 9. |
- Andersson, Maria, 1965-, et al.
(author)
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Energy system cost reduction as a result of end-use measures and the introduction of a biomass-fired co-generation plant
- 1993
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In: International Conference on Renewable Energy - Clean Power 2001. - London : Institution of Electrical Engineers (IEE). - 0852966059 ; , s. 37-42
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Conference paper (peer-reviewed)abstract
- This paper will describe an energy system analysis of an existing Swedish municipality of 90 000 inhabitants. The analysis, which is performed by using an optimization model will show what energy system measures that should be introduced to minimize the total energy system cost. In the existing municipality a local utility distributes heat, for the district heating system, and electricity. The heat is generated by the utility and the electricity is purchased from a large power producer.
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