| 1. |
- Andersson, Svante, 1962-, et al.
(author)
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Sustainable development considerations in supply chains : Firms' relationships with stakeholders in their business sustainability practices—A triangular comparison
- 2022
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In: Business Strategy and the Environment. - Oxford : John Wiley & Sons. - 0964-4733 .- 1099-0836. ; 32:4, s. 1885-1899
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Journal article (peer-reviewed)abstract
- This study aims to investigate focal firms' business sustainability relationships in connection with their stakeholders in supply chain networks. A questionnaire survey was sent to a sample consisting of large Swedish firms, with 107 usable questionnaires returned. The results reveal which stakeholders are of interest for firms in sustainability efforts. The results are compared with earlier findings from Norway and Spain in a triangular approach. The former is a similar country, while the latter is different to Sweden in several ways. In addition, the study uncovers which stakeholders in the supply chain network should be considered. The study also demonstrates how firms can implement business sustainability in their supply chain networks and shows the extent to which different stakeholders are considered in sustainability efforts. The study contributes to sustainability research and stakeholder theory in supply chain networks. Opposite to earlier findings, this study showed only minor influences from national culture and institutions on firms' sustainable business practices in supply chain networks. © 2022 The Authors. Business Strategy and The Environment published by ERP Environment and John Wiley & Sons Ltd.
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| 2. |
- Andersson, Svante, 1962-, et al.
(author)
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Sustainable development—Direct and indirect effects between economic, social, and environmental dimensions in business practices
- 2022
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In: Corporate Social Responsibility and Environmental Management. - Oxford : John Wiley & Sons. - 1535-3958 .- 1535-3966. ; 29:5, s. 1158-1172
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Journal article (peer-reviewed)abstract
- This study investigates the direct and indirect effects between economic, social and environmental dimensions of triple bottom line (TBL), based on a questionnaire survey and cross-industrial sample in Sweden. The analyses apply partial least squares structural equation models. The study tests the direct and indirect effects between economic, social, and environmental dimensions of TBL and offers additional validity and reliability to establish the measurement and structural properties between the dimensions of TBL. The study extends earlier findings by explicitly discussing how the three TBL goals relate to each other and shows how the dynamic capability view can be a fruitful lens to investigate business sustainability. Some differences in sustainability business practices caused by differences in national cultures are identified. Sustainability reporting in a strong uncertainty avoidance (UA) country happens in accordance with regulations and laws. Conversely, for weak UA cultures, reporting and compliance with regulations are ways to build trust with stakeholders. That is, reporting is more transparent and widespread in weak UA countries. The study also provides a foundation to guide companies' actions of business sustainability. The model shows companies how to establish the order of actions undertaken across economic, social, and environmental dimensions. In addition, it clarifies that the economic dimension exerts an effect on the social and environmental dimensions. The model also grasps long-term economic performance by including competitiveness and brand value, while earlier research mainly has focused on more short-term measurements as return on assets. © 2022 The Authors. Corporate Social Responsibility and Environmental Management published by ERP Environment and John Wiley & Sons Ltd.
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| 3. |
- Bergemalm, Daniel, 1977-, et al.
(author)
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Systemic Inflammation in Preclinical Ulcerative Colitis
- 2021
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In: Gastroenterology. - : AGA Institute. - 0016-5085 .- 1528-0012. ; 161:5, s. 1526-1539.e9
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Journal article (peer-reviewed)abstract
- Background & Aims: Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins.Methods: We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n = 72) and matched healthy controls (n = 140) within a population-based screening cohort. We measured 92 proteins related to inflammation using a proximity extension assay. The biologic relevance of these findings was validated in an inception cohort of patients with ulcerative colitis (n = 101) and healthy controls (n = 50). To examine the influence of genetic and environmental factors on these markers, a cohort of healthy twin siblings of patients with ulcerative colitis (n = 41) and matched healthy controls (n = 37) were explored.Results: Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in preclinical ulcerative colitis compared with controls based on both univariate and multivariable models. Ingenuity Pathway Analyses identified several potential key regulators, including interleukin-1β, tumor necrosis factor, interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4. For validation, we built a multivariable model to predict disease in the inception cohort. The model discriminated treatment-naïve patients with ulcerative colitis from controls with leave-one-out cross-validation (area under the curve = 0.92). Consistently, MMP10, CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the healthy twin siblings, even though their relative abundances seemed higher in incident ulcerative colitis.Conclusions: A set of inflammatory proteins are up-regulated several years before a diagnosis of ulcerative colitis. These proteins were highly predictive of an ulcerative colitis diagnosis, and some seemed to be up-regulated already at exposure to genetic and environmental risk factors.
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| 4. |
- Bergh, Niklas, 1979, et al.
(author)
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Invasive haemodynamics in de novo everolimus vs. calcineurin inhibitor heart transplant recipients
- 2020
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In: ESC Heart Failure. - : Wiley. - 2055-5822. ; 7:2, s. 567-576
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Journal article (peer-reviewed)abstract
- Aims: Invasive haemodynamic profiles at rest and during exercise after heart transplantation (HTx) have never been described in a randomized trial where de novo everolimus (EVR)-based therapy with early calcineurin inhibitor (CNI) withdrawal has been compared with conventional CNI treatment. We report central invasive haemodynamic parameters at rest and exercise during a 3 year follow-up after HTx in a sub-study of the SCandiavian Heart transplant Everolimus De novo stUdy with earLy calcineurin inhibitor avoidancE trial. We hypothesized that the nephroprotective properties, the less development of cardiac allograft vasculopathy (CAV), and the antifibrotic properties of EVR, in comparison with CNI-based immunosuppression, would demonstrate favourable invasive haemodynamic profiles in patients at rest and during exercise. Methods and results: Ninety of 115 HTx recipients randomized to EVR or CNI treatment performed right heart catheterization at rest and 68 performed right heart catheterization at exercise up to 3 years after HTx. Haemodynamic profiles were compared between EVR and CNI treatment groups. Resting haemodynamics improved in both groups from pre-HTx to the first follow-up at 7–11 weeks post-HTx and thereafter remained unchanged up to 3 years of follow-up. During follow-up, cardiac reserve during exercise increased with higher levels of maximum heart rate (118 to 148 b.p.m., P < 0.001), mean arterial pressure (103 to 128 mmHg, P < 0.001), and cardiac output (10.3 to 12.2 l/min, P < 0.001). No significant differences in haemodynamic parameters were observed between the EVR and CNI groups at rest or exercise. Isolated post-capillary pulmonary hypertension (mean pulmonary arterial pressure > 20 mmHg, pulmonary arterial wedge pressure ≥ 15 mmHg, and pulmonary vascular resistance <3) were measured in 11% of the patients at 7–11 weeks, 5% at 12 months, and 6% at 36 months after HTx. The EVR group had significantly better kidney function (76 mL/min/1 vs. 60 mL/min/1, P < 0.001) and reduced CAV (P < 0.01) but an increased rate of early biopsy-proven treated rejections (21.2% vs 5.7%, P < 0.01) compared with the CNI group at any time point. The differences in renal function, CAV, or early biopsy-proven treated acute rejections were not associated with altered haemodynamics. Conclusions: De novo EVR treatment with early CNI withdrawal compared with conventional CNI therapy did not result in differences in haemodynamics at rest or during exercise up to 3 years after HTx despite significant differences in renal function, reduced CAV, and number of early biopsy-proven treated rejections.
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| 5. |
- Costa, Fabíola Paula, et al.
(author)
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Aerodynamic Analysis of Conventional and Boundary Layer Ingesting Propellers
- 2023
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In: Journal of Engineering for Gas Turbines and Power. - : ASME International. - 1528-8919 .- 0742-4795. ; 145:1
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Journal article (peer-reviewed)abstract
- The boundary layer ingestion (BLI) concept has emerged as a novel technology for reducing aircraft fuel consumption. Several studies designed BLI-fans for aircraft. BLI-propellers, although, have still received little attention, and the choice of open-rotors or ducted propellers is still an open question regarding the best performance. The blade design is also challenging because the BLI-propulsors ingest a nonuniform flow. These aspects emphasize further investigation of unducted and ducted BLI-propulsors and the use of optimization frameworks, coupled with computational fluid dynamics simulations, to design the propeller to adapt to the incoming flow. This paper uses a multi-objective NSGA-II optimization framework, coupled with three-dimensional RANS simulations and radial basis function (RBF) metamodeling, used for the design and optimization of three propeller configurations at cruise conditions: (a) conventional propeller operating in the freestream, (b) unducted BLI-propeller, and (c) ducted BLI-propeller, both ingesting the airframe boundary layer. The optimization results showed a significant increase in chord and a decrease in the blade angles in the BLI configurations, emphasizing that these geometric parameters optimization highly affects the BLI-blade design. The unducted BLI-propeller needs approximately 40% less shaft power than the conventional propeller to generate the same amount of propeller force. The ducted BLI-propeller needs even less power, 47%. The duct contributes to the tip vortex weakening, recovering the swirl, and turning into propeller force, as noticed from 80% of the blade span to the tip. However, the unducted and ducted BLI-configurations presented a higher backward force, 26% and 46%, respectively, compared to the conventional propeller, which can be detrimental and narrow the use of these configurations.
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| 6. |
- Ljungman, Charlotta, 1977, et al.
(author)
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Differences in phenotypes, symptoms, and survival in patients with cardiomyopathy-a prospective observational study from the Sahlgrenska CardioMyoPathy Centre.
- 2023
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In: Frontiers in cardiovascular medicine. - 2297-055X. ; 10
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Journal article (peer-reviewed)abstract
- Cardiomyopathy is the fourth most common cause of heart failure. The spectrum of cardiomyopathies may be impacted by changes in environmental factors and the prognosis may be influenced by modern treatment. The aim of this study is to create a prospective clinical cohort, the Sahlgrenska CardioMyoPathy Centre (SCMPC) study, and compare patients with cardiomyopathies in terms of phenotype, symptoms, and survival.The SCMPC study was founded in 2018 by including patients with all types of suspected cardiomyopathies. This study included data on patient characteristics, background, family history, symptoms, diagnostic examinations, and treatment including heart transplantation and mechanical circulatory support (MCS). Patients were categorized by the type of cardiomyopathy on the basis of the diagnostic criteria laid down by the European Society of Cardiology (ESC) working group on myocardial and pericardial diseases. The primary outcomes were death, heart transplantation, or MCS, analyzed by Kaplan-Meier and Cox proportional regression, adjusted for age, gender, LVEF and QRS width on ECG in milliseconds.In all, 461 patients and 73.1% men with a mean age of 53.6±16 years were included in the study. The most common diagnosis was dilated cardiomyopathy (DCM), followed by cardiac sarcoidosis and myocarditis. Dyspnea was the most common initial symptom in patients with DCM and amyloidosis, while patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) presented with ventricular arrythmias. Patients with ARVC, left-ventricular non-compaction cardiomyopathy (LVNC), hypertrophic cardiomyopathy (HCM), and DCM had the longest time from the debut of symptoms until inclusion in the study. Overall, 86% of the patients survived without heart transplantation or MCS after 2.5 years. The primary outcome differed among the cardiomyopathies, where the worst prognosis was reported for ARVC, LVNC, and cardiac amyloidosis. In a Cox regression analysis, it was found that ARVC and LVNC were independently associated with an increased risk of death, heart transplantation, or MCS compared with DCM. Further, female gender, a lower LVEF, and a wider QRS width were associated with an increased risk of the primary outcome.The SCMPC database offers a unique opportunity to explore the spectrum of cardiomyopathies over time. There is a large difference in characteristics and symptoms at debut and a remarkable difference in outcome, where the worst prognosis was reported for ARVC, LVNC, and cardiac amyloidosis.
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| 7. |
- Minelli, Guglielmo, 1988, et al.
(author)
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An aeroacoustic study of the flow surrounding the front of a simplified ICE3 high-speed train model
- 2020
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In: Applied Acoustics. - : Elsevier BV. - 0003-682X .- 1872-910X. ; 160
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Journal article (peer-reviewed)abstract
- A numerical study using IDDES is carried out to investigate the aerodynamic and the aeroacoustic response of a simplified ICE3 high-speed train model. The work focuses on the front part of the train and, in particular, on the first bogie cavity. The choice is justified by a literature survey which shows that this part of the train is the principal contributor of critical noise pollution created at pass-by in populated areas. Detailed CFD can provide useful insight and be of great importance in the identification of noise generation mechanisms and their relation with the flow structures. Results show the formation of two main aerodynamic structures with a clear relation to the aeroacoustic response calculated on the train and ground surfaces. Simulations were made at Re=1.8×105 and M=0.058 to match the experimental observations found in literature and generate a set of benchmark data for future investigations.
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| 8. |
- Minelli, Guglielmo, 1988, et al.
(author)
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Using horizontal sonic crystals to reduce the aeroacosutic signature of a simplified ICE3 train model
- 2021
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In: Applied Acoustics. - : Elsevier BV. - 0003-682X .- 1872-910X. ; 172
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Journal article (peer-reviewed)abstract
- The design of noise barriers for high-speed trains is challenging due to the flow interaction between the train body and barriers. A failed design could affect the flow that in turn introduces additional aerodynamic loads to the train and generates extra noise. This study is the first investigation to numerically explore the detailed effects of noise barriers on high-speed trains. In particular, horizontal sonic crystals are compared to vertical, closed at the ground barriers in order to investigate the detailed effects of different noise screens on high-speed trains. The compressible IDDES is used to simulate the flow. The focus of this study is twofold. The first is to test if an alternative barrier typology can effectively reduce the noise signature, without having an impact on the train’s aerodynamic performance. The second is to explore the connection between the near-field velocity fluctuations and the far-field noise. A few specific tonal frequency components have been commonly reported but not clearly explained in the literature. It is unclear if the specific tonal components are less dependent on the Reynolds numbers, although, in general, energetic flow structures are dependent on inflow speeds. Concerning the noise reduction, the results show that the sonic crystal barrier case has a significantly better performance. A modal analysis is used to explore the causes of the tonal peaks and the association of the underbody swirling vortices to the far-field noise is described.
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| 9. |
- Wilhelmson, Katarina, 1958, et al.
(author)
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Comprehensive Geriatric Assessment for Frail Older People in Swedish Acute Care Settings (CGA-Swed) : A Randomised Controlled Study
- 2020
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In: Geriatrics (Basel, Switzerland). - : MDPI AG. - 2308-3417 .- 0016-867X. ; 5:1
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Journal article (peer-reviewed)abstract
- The aim of the study is to evaluate the effects of the Comprehensive Geriatric Assessment (CGA) for frail older people in Swedish acute hospital settings - the CGA-Swed study. In this study protocol, we present the study design, the intervention and the outcome measures as well as the baseline characteristics of the study participants. The study is a randomised controlled trial with an intervention group receiving the CGA and a control group receiving medical assessment without the CGA. Follow-ups were conducted after 1, 6 and 12 months, with dependence in activities of daily living (ADL) as the primary outcome measure. The study group consisted of frail older people (75 years and older) in need of acute medical hospital care. The study design, randomisation and process evaluation carried out were intended to ensure the quality of the study. Baseline data show that the randomisation was successful and that the sample included frail older people with high dependence in ADL and with a high comorbidity. The CGA contributed to early recognition of frail older people's needs and ensured a care plan and follow-up. This study is expected to show positive effects on frail older people's dependence in ADL, life satisfaction and satisfaction with health and social care.
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