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- Andersson, Bert, 1952, et al.
(författare)
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När hjärtat sviker
- 2004
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Bok (övrigt vetenskapligt/konstnärligt)
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- Andersson, Stefan, et al.
(författare)
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Wideband LNA for a Multistandard Wireless Receiver in 0.18 μm CMOS
- 2003
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Ingår i: Proceedings of the 29th European Solid-State Circuits Conference, 2003. ESSCIRC '03. - 0780379950 ; , s. 655-658
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Konferensbidrag (refereegranskat)abstract
- A differential wideband LNA for a multistandard receiver has been designed and implemented in 0.18μm CMOS. The circuit topology is a two-stage amplifier with active feedback. The input stage is a common-source stage with a common-drain stage in the feedback loop for impedance matching. Bandwidth enhancement with inductive shunt-peaking is used for maximizing the bandwidth. Measurements on the fabricated device show a power gain of 13.1 dB and a 3-dB bandwidth of nearly 7 GHz together with an IIP3 and a 1-dB compression point of -4.7 dBm and -15.2 dBm respectively. The measured noise figures are 3.3 dB at 1 GHz and 5.5 dB at 6 GHz. Reported LNAs with similar performance are usually implemented with bipolar transistors or MESFETs.
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- Masson, Patrick, et al.
(författare)
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Identification and characterization of a Drosophila nuclear proteasome activator : a homolog of human 11S REggamma (PA28gamma)
- 2001
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Ingår i: Journal of Biological Chemistry. - 0021-9258 .- 1083-351X. ; 276:2, s. 1383-1390
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Tidskriftsartikel (refereegranskat)abstract
- We report the cloning and characterization of aDrosophila proteasome 11 S REGγ (PA28) homolog. The 28-kDa protein shows 47% identity to the human REGγ and strongly enhances the trypsin-like activities of both Drosophila and mammalian 20 S proteasomes. Surprisingly, the DrosophilaREG was found to inhibit the proteasome's chymotrypsin-like activity against the fluorogenic peptide succinyl-LLVY-7-amino-4-methylcoumarin. Immunocytological analysis reveals that the Drosophila REG is localized to the nucleus but is distributed throughout the cell when nuclear envelope breakdown occurs during mitosis. Through site-directed mutagenesis studies, we have identified a functional nuclear localization signal present in the homolog-specific insert region. TheDrosophila PA28 NLS is similar to the oncogene c-Myc nuclear localization motif. Comparison between uninduced and innate immune induced Drosophila cells suggests that the REGγ proteasome activator has a role independent of the invertebrate immune system. Our results support the idea that γ class proteasome activators have an ancient conserved function within metazoans and were present prior to the emergence of the α and β REG classes.
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