| 1. |
- Andersson, Cecilia K, et al.
(författare)
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Activated MCTC mast cells infiltrate diseased lung areas in cystic fibrosis and idiopathic pulmonary fibrosis
- 2011
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Ingår i: Respiratory Research. - : Springer Science and Business Media LLC. - 1465-9921 .- 1465-993X. ; 12:139
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Tidskriftsartikel (refereegranskat)abstract
- Background: Although mast cells are regarded as important regulators of inflammation and tissue remodelling, their role in cystic fibrosis (CF) and idiopathic pulmonary fibrosis (IPF) has remained less studied. This study investigates the densities and phenotypes of mast cell populations in multiple lung compartments from patients with CF, IPF and never smoking controls. Methods: Small airways, pulmonary vessels, and lung parenchyma were subjected to detailed immunohistochemical analyses using lungs from patients with CF (20 lung regions; 5 patients), IPF (21 regions; 7 patients) and controls (16 regions; 8 subjects). In each compartment the densities and distribution of MCT and MCTC mast cell populations were studied as well as the mast cell expression of IL-6 and TGF-beta. Results: In the alveolar parenchyma in lungs from patients with CF, MCTC numbers increased in areas showing cellular inflammation or fibrosis compared to controls. Apart from an altered balance between MCTC and MCT cells, mast cell in CF lungs showed elevated expression of IL-6. In CF, a decrease in total mast cell numbers was observed in small airways and pulmonary vessels. In patients with IPF, a significantly elevated MCTC density was present in fibrotic areas of the alveolar parenchyma with increased mast cell expression of TGF-beta. The total mast cell density was unchanged in small airways and decreased in pulmonary vessels in IPF. Both the density, as well as the percentage, of MCTC correlated positively with the degree of fibrosis. The increased density of MCTC, as well as MCTC expression of TGF-beta, correlated negatively with patient lung function. Conclusions: The present study reveals that altered mast cell populations, with increased numbers of MCTC in diseased alveolar parenchyma, represents a significant component of the histopathology in CF and IPF. The mast cell alterations correlated to the degree of tissue remodelling and to lung function parameters. Further investigations of mast cells in these diseases may open for new therapeutic strategies.
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| 2. |
- Andersson, Evert, et al.
(författare)
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Green Train: concept and technology overview
- 2014
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Ingår i: International Journal of Rail Transportation. - : Taylor & Francis Group. - 2324-8386 .- 2324-8378. ; 2:1, s. 2-16
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Tidskriftsartikel (refereegranskat)abstract
- Green Train (in Swedish, Gröna Tåget) is a research, development and demonstrationprogramme with the overall objective to define an economical, flexible and environmentallyfriendly train concept. The objective is also to develop technology for futurehigh-speed trains for the northern European market, particularly for Scandinavia. Mostof the technology developed is also applicable to other world markets, as well as toslower trains. The programme has covered many important areas, including economy,capacity and market aspects, conceptual design, traveller attractiveness and interiors,travel time, energy efficiency and noise, winter performance, track friendliness and carbody tilt, aerodynamics, electric propulsion and current collection. The programme hasconducted fundamental analysis and research on the different issues as well as designand testing of new technologies. A number of crucial technologies have undergoneperformance and type testing both in lab and on a test train. Experience feedback wasachieved in commercial train service during the period 2006−2013 including harshwinters. This paper summarises a great deal of research and development that has beenperformed in the Green Train programme.
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| 3. |
- Andersson, Erik, 1966, et al.
(författare)
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Konsumtionens finansialisering
- 2014
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Ingår i: Konsumtionsrapporten 2014. - Göteborg : University of Gothenburg. ; , s. 35-39
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Andersson, Evert, et al.
(författare)
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TOSCA. Rail freight transport : Techno-economic analysis of energy and greenhouse gas reductions
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In Stage 1 of the EU/FP7-funded project TOSCA (Technology Opportunities and Strategies toward Climate-friendly trAnsport) the techno-economical feasibility of different technolo-gies and means to reduce greenhouse gas (GHG) emissions is being analysed for different modes of transport. This is made over the long-term perspective until 2050, with 2009 as the reference year. This is the report on the rail freight transport market, applicable to the European Union (EU-27).The analysis presented in this report estimates that a number of efficient technologies and means are available, individually and in combination, to significantly reduce energy use and the resulting GHG emissions on the rail freight market until 2050. The analysis has considered the following technologies and means:– heavy freight trains (high payload capacity per metre of train as well as longer trains)– eco-driving, including traffic flow management– energy recovery– high-efficiency machinery in locomotives and electric supply– low air drag– incremental improvements, in particular reduced tare mass of wagons.Despite anticipated higher train speeds in most future train operations the above-mentioned technologies and means have, according to the analysis, the potential to reduce the average energy use per net-tonne-km (tkm) of payload by 40–50 % until 2050. As a consequence also the direct and indirect GHG emissions will be reduced. Energy use and GHG emissions are measured per net-tonne-km, assuming representative load factors in different operations.
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| 5. |
- Andersson, Evert, et al.
(författare)
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TOSCA. Rail passenger transport : Techno-economic analysis of energy and greenhouse gas reductions
- 2011
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- In Stage 1 of the EU/FP7-funded project TOSCA (Technology Opportunities and Strategies toward Climate-friendly trAnsport) the techno-economical feasibility of different technologies and means to reduce greenhouse gas (GHG) emissions is being analysed for the different modes of transport. This is made in the long-term perspective until 2050, with 2009 as the reference year. This is the report on rail passenger transport, applicable to the European Union (EU-27).The present report has been subject to review among railway experts, representing train suppliers, railway operators as well as academia. They have also responded to a questionnaire. Further, a workshop was held, where the report with assumptions and results was discussed.In the analysis presented in this report it is estimated that a number of efficient improvements that, individually and in combination, are available in order to significantly reduce energy use and the resulting GHG emissions on the rail passenger market until 2050. The analysis has considered different technologies and means:– low air drag– low train mass– energy recovery– eco-driving, including traffic flow management– space efficiency in trains (increasing payload per metre of train)– incremental improvements of energy efficiency, in particular reduced losses.Despite anticipated higher average train speeds in the future these combined approaches will, according to the analysis, have the potential to reduce the average specific energy use per passenger-km (pkm) in the order of 45–50 % in the very long term until 2050. As a consequ-ence also the direct and indirect GHG emissions will be reduced. The highest reductions are possible in city and regional rail operations. Reductions are more limited in high-speed opera-tions, because of the advanced technologies already applied. However, high-speed rail has today a comparatively low energy use per passenger-km, partly due to its high average load factor. To be consistent with other work packages of TOSCA, energy use and GHG emissions are measured per passenger-km, assuming representative load factors in different operations.
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| 10. |
- Andersson, Marie, et al.
(författare)
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Maternal Transfer of the Cyanobacterial Neurotoxin beta-N-Methylamino-L-Alanine (BMAA) via Milk to Suckling Offspring
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 8:10, s. e78133-
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Tidskriftsartikel (refereegranskat)abstract
- The cyanobacterial neurotoxin beta-N-methylamino-L-alanine (BMAA) has been implicated in the etiology of neurodegenerative disease and proposed to be biomagnified in terrestrial and aquatic food chains. We have previously shown that the neonatal period in rats, which in humans corresponds to the last trimester of pregnancy and the first few years of age, is a particularly sensitive period for exposure to BMAA. The present study aimed to examine the secretion of C-14-labeled L-and D-BMAA into milk in lactating mice and the subsequent transfer of BMAA into the developing brain. The results suggest that secretion into milk is an important elimination pathway of BMAA in lactating mothers and an efficient exposure route predominantly for L-BMAA but also for D-BMAA in suckling mice. Following secretion of [C-14] L-BMAA into milk, the levels of [C-14] L-BMAA in the brains of the suckling neonatal mice significantly exceeded the levels in the maternal brains. In vitro studies using the mouse mammary epithelial HC11 cell line confirmed a more efficient influx and efflux of L-BMAA than of D-BMAA in cells, suggesting enantiomer-selective transport. Competition experiments with other amino acids and a low sodium dependency of the influx suggests that the amino acid transporters LAT1 and LAT2 are involved in the transport of L-BMAA into milk. Given the persistent neurodevelopmental toxicity following injection of L-BMAA to neonatal rodent pups, the current results highlight the need to determine whether BMAA is enriched mother's and cow's milk.
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