| 1. |
- Andersson, David A., et al.
(author)
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TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Delta(9)-tetrahydrocannabiorcol
- 2011
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 2
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Journal article (peer-reviewed)abstract
- TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics. Here we show that the antinociceptive effects of spinal and systemic administration of acetaminophen (paracetamol) are lost in Trpa1(-/-) mice. The electrophilic metabolites N-acetyl-p-benzoquinoneimine and p-benzoquinone, but not acetaminophen itself, activate mouse and human TRPA1. These metabolites also activate native TRPA1 and, as a consequence, reduce voltage-gated calcium and sodium currents in primary sensory neurons. The N-acetyl-p-benzoquinoneimine metabolite l-cysteinyl-S-acetaminophen was detected in the mouse spinal cord after systemic acetaminophen administration. In the hot-plate test, intrathecal administration of N-acetyl-p-benzoquinoneimine, p-benzoquinone and the electrophilic TRPA1 activator cinnamaldehyde produced antinociception that was lost in Trpa1(-/-) mice. Intrathecal injection of a non-electrophilic cannabinoid, Delta(9)-tetrahydrocannabiorcol, also produced TRPA1-dependent antinociception in this test. Our study provides a molecular mechanism for the antinociceptive effect of acetaminophen and discloses spinal TRPA1 activation as a potential pharmacological strategy to alleviate pain.
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| 4. |
- Andersson, Eva Ingeborg Elisabeth, 1956, et al.
(author)
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TSA II Stenungsund - Investigation of opportunities for implementation of proposed energy efficiency measures
- 2011
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Reports (other academic/artistic)abstract
- A Total Site Analysis (TSA) study of the chemical cluster in Stenungsund was conducted during 2010. This previous study is hereafter referred to as the TSA I study. The study was conducted by CIT Industriell Energi and the Division of Heat and Power Technology at Chalmers together with the participating cluster companies (AGA Gas AB, Akzo Nobel Sverige AB, Borealis AB, INEOS Sverige AB and Perstorp Oxo AB).In the TSA I study, measures to increase energy efficiency by increased energy collaboration (i.e. increased heat exchange between the cluster plants) were identified. The measures were classified according to ease of implementation based on consultation with plant staff. In this report, conducted within the framework of the second stage of the TSA research project (hereafter referred to as the TSA II project) practical issues associated with implementation of the identified measures are investigated. The investigation is limited to category A measures, considered by plant staff to be relatively easy to implement from a technical perspective. A conceptual design of a possible hot water system for exchanging heat between the different sites is presented. Since the steam systems of the different plants are at present only partly connected, or not at all, the overall reduction in steam use that would results from introduction of a hot water system would lead to steam surplus at certain sites. Therefore introducing a hot water system is only beneficial if new steam lines are also implemented so that it becomes possible to exchange steam between the individual plant sites. The exchange of steam is only possible if steam demand and steam excess are at the same pressure level. To avoid excess steam at low pressure level, demand of low pressure steam must increase. In order to increase the possibility to use more low pressure steam, the opportunities to decrease utility steam pressure in individual process heaters are analyzed. The implementation of energy efficiency measures in the refrigeration systems is also investigated. In practice this can be achieved by changing steam as heating utility to a fluid that can operate below ambient. In addition to the steam saving, the heat transfer fluid can transport energy from the current cooling systems and decrease the amount of compressor work required to operate the existing refrigeration system units.In order to achieve a reduction of purchased fuel for firing in boilers it is necessary to implement both a common site-wide circulating hot water system and a reduction of utility steam pressure used in several process heaters .The results show that if all measures that are considered by plant energy engineers to be feasible by moderate changes are carried out as suggested, fuel usage in boilers could be reduced by 89 MW (corresponding to 200 MSEK/year if fuel gas is valued at 270 SEK/MWh and year-round operation is assumed).A rough estimate of the total investment costs for the implementation of category A measures is 660 MSEK.
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- Andersson, Simon, 1980-
(author)
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Rättsdogmatisk metod och bevisvärdering
- 2014
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In: Festskrift till Christian Diesen. - Stockholm : Norstedts Juridik AB. - 9789139018032 ; , s. 427-450
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Book chapter (other academic/artistic)
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| 7. |
- Bocchetta, Carlo, et al.
(author)
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Project Status of the Polish Synchrotron Radiation Facility Solaris
- 2011
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In: Proceedings of IPAC2011. - 9789290833666 ; , s. 3014-3016
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Conference paper (other academic/artistic)abstract
- Abstract in Undetermined The Polish synchrotron radiation facility Solaris is being built at the Jagiellonian University in Krakow. The project is based on an identical copy of the 1.5 GeV storage ring being concurrently built for the MAX IV project in Lund, Sweden. A general description of the facility is given together with a status of activities. Unique features associated with Solaris are outlined, such as infrastructure, the injector and operational characteristics.
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| 8. |
- Bower, Peter, et al.
(author)
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Influence of initial severity of depression on effectiveness of low intensity interventions : meta-analysis of individual patient data
- 2013
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In: BMJ (Clinical Research Edition). - : BMJ Publishing Group: BMJ. - 0959-8138 .- 1756-1833. ; 346
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Journal article (peer-reviewed)abstract
- Objective To assess how initial severity of depression affects the benefit derived from low intensity interventions for depression.Design Meta-analysis of individual patient data from 16 datasets comparing low intensity interventions with usual care.Setting Primary care and community settings.Participants 2470 patients with depression.Interventions Low intensity interventions for depression (such as guided self help by means of written materials and limited professional support, and internet delivered interventions).Main outcome measures Depression outcomes (measured with the Beck Depression Inventory or Center for Epidemiologic Studies Depression Scale), and the effect of initial depression severity on the effects of low intensity interventions.Results Although patients were referred for low intensity interventions, many had moderate to severe depression at baseline. We found a significant interaction between baseline severity and treatment effect (coefficient −0.1 (95% CI −0.19 to −0.002)), suggesting that patients who are more severely depressed at baseline demonstrate larger treatment effects than those who are less severely depressed. However, the magnitude of the interaction (equivalent to an additional drop of around one point on the Beck Depression Inventory for a one standard deviation increase in initial severity) was small and may not be clinically significant.Conclusions The data suggest that patients with more severe depression at baseline show at least as much clinical benefit from low intensity interventions as less severely depressed patients and could usefully be offered these interventions as part of a stepped care model.
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| 10. |
- Dobbins, Sara E., et al.
(author)
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Common variation at 10p12.31 near MLLT10 influences meningioma risk
- 2011
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In: Nature Genetics. - London : Nature America, Inc.. - 1061-4036 .- 1546-1718. ; 43:9, s. 825-827
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Journal article (peer-reviewed)abstract
- To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 x 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.
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