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- Adestam, Johan, 1982-, et al.
(author)
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Associationsrättens grunder
- 2022. - 1
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Book (other academic/artistic)abstract
- En betydande del av näringslivet och civilsamhället bedrivs av och i olika slags associationer. Associationsrätt handlar om de regler som möjliggör och styr verksamheten i associationerna. Associationsrättens grunder ger en systematisk överblick över rättsområdet och dess centrala problem. Fokus ligger på allmänna bolags- och föreningsformer, men boken redogör även för regleringen av stiftelser. I boken diskuteras frågor om juridisk personlighet, ansvar för förpliktelser, beslutsfattande, företrädarskap, medlemsskydd, borgenärsskydd och redovisning och revision. Utöver detta behandlas vissa straffrättsliga regler av betydelse för bedrivande av verksamhet i företag och företagsbot som särskild sanktion. Boken placerar associationsrätten i en samhällelig kontext, bland annat mot bakgrund av de hållbarhetssträvanden som sker inom EU och internationellt. Associationsrättens grunder vänder sig i första hand till studenter inom juridikutbildningar men kan också användas som vägledning för den som är praktiskt verksam inom området.
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| 2. |
- Adestam, Johan, 1982-, et al.
(author)
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Avtalsbrott och skadestånd : skuldprincipen i svensk avtalsrätt
- 2021
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In: Svensk Juristtidning. - 0039-6591. ; , s. 48-60
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Journal article (peer-reviewed)abstract
- Sedan länge är skuldprincipen den rådande huvudregeln i svensk rätt i fråga om skadestånd till följd av avtalsbrott. Detta innebär att svensk avtalsrätt bygger på ett oaktsamhetskrav. Det skriver författarna i denna replik till Christina Ramberg (SvJT 2020 s. 589).
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| 3. |
- Adestam, Johan, 1982-, et al.
(author)
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Avtalsrättsligt medhjälparansvar
- 2022
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In: Svensk Juristtidning. - 0039-6591. ; 2022:1, s. 98-123
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Journal article (other academic/artistic)abstract
- Det inomobligatoriska medhjälparansvaret har länge ansetts bygga på oskrivna tillräknanderegler. Anta att B anlitar C för att utföra något som uppfyller B:s avtalsförpliktelse mot A och att C orsakar A skada genom handlingen eller underlåtelsen H. Frågan om B:s skadeståndsansvar mot A ska enligt dessa regler avgöras på samma sätt som om B själv hade företagit H. De centrala frågorna blir då om H strider mot någon avtalsförpliktelse som B har mot A och om C har företagit H på ett sådant sätt att den i relationen mellan A och B tillämpliga ansvarsgrunden (t.ex. oaktsamhet) är uppfylld. Den traditionella bilden har emellertid utmanats i litteraturen och även i prejudikatet NJA 2018 s. 301. Artikeln argumenterar för att de konkurrerande beskrivningarna är omotiverade och att gällande rätt alltjämt svarar mot den traditionella bilden.
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| 4. |
- Adestam, Johan, 1982-, et al.
(author)
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Nytt prejudikat om tidpunkten för uppkomsten av en förpliktelse att ersätta rättegångskostnader vid tillämpning av medansvarsreglerna i 25 kap. ABL
- 2020
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Other publication (other academic/artistic)abstract
- De senaste åren har det kommit många prejudikat rörande medansvar vid kritisk kapitalbrist i 25 kap. aktiebolagslagen (ABL). I ett nytt prejudikat klargör Högsta domstolen när ett aktiebolags förpliktelse att lämna ersättning för rättegångskostnader ska anses ha uppkommit vid tillämpning av 25 kap. 18 § ABL. Trots den ofta upprepade utgångspunkten att reglernas ändamål är att verka handlingsdirigerande genom att medansvaret verkar som ett påtryckningsmedel för styrelseledamöterna har det delvis varit oklart vilken betydelse detta haft för utgången i tidigare fall. Det nya prejudikatet klarlägger och kompletterar bilden genom att även lägga vikt vid reglernas funktion av att skydda enskilda borgenärer mot riskökningar. Prejudikatet analyseras av jur. dr Johan Adestam, lektor i rättsvetenskap och jur. dr och docent Niklas Arvidsson.
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| 5. |
- Ahrén, Irini Lazou, et al.
(author)
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Fewer Community-Acquired Colds with Daily Consumption of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2. A Randomized, Placebo-Controlled Clinical Trial
- 2021
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In: The Journal of nutrition. - : Elsevier BV. - 1541-6100 .- 0022-3166. ; 151:1, s. 214-222
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Journal article (peer-reviewed)abstract
- BACKGROUND: Viral infections of the upper airways are the most common cause for absence from work or school, and there is evidence for probiotic efficacy in reducing the incidence and severity of these infections.OBJECTIVES: We aimed to confirm the previously reported beneficial effects of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 against community-acquired common colds and identify a possible mechanism of action.METHODS: In a double-blind study, healthy adults (18-70 years of age) with at least 4 colds during the last 12 months before recruitment were randomly allocated to consume either probiotics (n = 448; total daily dose of 109 CFU with the 2 strains equally represented) or placebo (n = 450) once daily for 12 weeks. Recruitment took place from October to February during 2013-2016 (over 3 cold seasons). The probiotic impact on the severity of the colds (Wisconsin Upper Respiratory Symptom Survey-21) was the primary endpoint, whereas secondary endpoints included the incidence rate and duration of colds and an analysis of immune markers. Mann-Whitney U test and mixed model were used for the analysis of continuous variables and Fisher´s exact test was used for the analysis of categorical endpoints.RESULTS: Symptom severity was not reduced after intake of the probiotic, despite the positive trend seen in the first season. However, significantly fewer colds were experienced in the probiotic group (mean of 1.24 colds) as compared to the placebo group (mean of 1.36 colds; P = 0.044) for subjects reporting at least 1 cold, the incidence of recurring colds was 30% lower (20.8% vs. 29.8%, respectively; P = 0.055), and the use of analgesics was 18% lower (26.3% vs. 32%, respectively; P = 0.07). After 12 weeks, the change from baseline for IFN-γ differed between the groups (mean difference of -7.01; 95% CI, -14.9 to 0.93; P = 0.045).CONCLUSIONS: Intake of Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2 can be protective against multiple colds in adults prone to getting colds.This trial was registered at clinicaltrials.gov as NCT02013934.
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| 7. |
- Andersen, Paul Krüger, et al.
(author)
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Response to the Proposal for a Directive on Corporate Sustainability Due Diligence by Nordic and Baltic Company Law Scholars
- 2022
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Other publication (other academic/artistic)abstract
- On February 23, 2022, The EU Commission published its Proposal for a Directive of the European Parliament and of the Council on Corporate Sustainability Due Diligence and amending Directive (EU) 2019/1937 (“CSDDD” or “the Proposal”). The purpose of the Proposal, to further the “Union’s transition to a climate-neutral and green economy in line with the European Green Deal and in delivering on the UN Sustainable Development Goals”, is of great importance, and the Commission’s initiative is therefore commendable. However, it is our firm opinion that the Proposal should not be enacted in its present form, and that if it were to be, it would not only damage European businesses but also run the risk of having an adverse effect on both the transition to a climate-neutral economy as well as the goal of delivering on the UN Sustainable Development Goals. This is to a large extent because many of the Proposal’s provisions are excessive, unfounded and disproportionate and as such in violation of the fundamental principles of subsidiarity and proportionality safeguarded by Art. 5 TEU as well as having a questionable basis in Art. 50 TFEU. Furthermore and in regard of procedure, we find that the presentation of the Proposal by the Commission represents a disregard for the principles of better regulation that should not pass unnoticed and must be observed in the future to maintain trust in the legislative process of the Union.In this response to the consultation, we have presented an analysis of the key issues of the Proposal from a corporate governance perspective. We have divided the response into two parts: one on the pure corporate governance parts of the Proposal (article 15, 25 and 26) and one of the due diligence parts of the Proposal. With regards to the corporate governance parts of the Proposal, our conclusion is that they, by and large, should not be included in the proposed directive at all. Including them would in several ways be in breach of the EU principles on subsidiarity and proportionality, but perhaps more importantly, they are not only unsubstantiated by available empirical evidence on corporate behaviour, but also refuted by what we know. There is also good reason to believe that the proposed rules on director’s duties and environmental remuneration would risk decreasing the effectiveness of the stock markets within the EU contrary to the goal of a Capital Market Union, which also risk slowing down the necessary transition to a green economy and the goals of the EU Green Deal. The regulation necessary for the Capital Market Union and the EU Green Deal should complement each other, not collide as would be the outcome if the Proposal is adopted in its present form.With regards to the due diligence parts of the Proposal, our criticism is limited to corporate governance aspects and far less fundamental. We primarily believe that grounds for harmonisation needs further consideration in the present very challenging times, that Article 22 on Civil Liability might in several ways be counter-productive to the goals of the Proposal, that the effects on SMEs as well as for the financial companies included covered by the Proposal warrants further analysis, that the choice to focus the Proposal on individual companies instead of company groups needs to be reviewed, and that a risk based approach should be taken rather than an approach were companies are unable to focus their efforts to where they can be most effective. Overall, these issues can be worked out, but if they are not, then the proposed directive would not only have a severe adverse impact on EU companies and possibly capital markets, but might actually hinder EU companies from acting in the way that the Proposal aims for them to do.This joint response to the public consultation is made by a group of Nordic and Baltic company law scholars who, although we may not agree on every detail, do share the main arguments and grave concerns expressed here.
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| 8. |
- Arvidsson, Ida, et al.
(author)
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Comparing a pre-defined versus deep learning approach for extracting brain atrophy patterns to predict cognitive decline due to Alzheimer’s disease in patients with mild cognitive symptoms
- 2024
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In: Alzheimer's Research and Therapy. - 1758-9193. ; 16:1
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Journal article (peer-reviewed)abstract
- Background: Predicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural brain imaging as measured by magnetic resonance imaging (MRI) could potentially contribute when making such predictions. It is unclear if the predictive performance of MRI can be improved using entire brain images in deep learning (DL) models compared to using pre-defined brain regions. Methods: A cohort of 332 individuals with SCD/MCI were included from the Swedish BioFINDER-1 study. The goal was to predict longitudinal SCD/MCI-to-AD dementia progression and change in Mini-Mental State Examination (MMSE) over four years. Four models were evaluated using different predictors: (1) clinical data only, including demographics, cognitive tests and APOE ε4 status, (2) clinical data plus hippocampal volume, (3) clinical data plus all regional MRI gray matter volumes (N = 68) extracted using FreeSurfer software, (4) a DL model trained using multi-task learning with MRI images, Jacobian determinant images and baseline cognition as input. A double cross-validation scheme, with five test folds and for each of those ten validation folds, was used. External evaluation was performed on part of the ADNI dataset, including 108 patients. Mann-Whitney U-test was used to determine statistically significant differences in performance, with p-values less than 0.05 considered significant. Results: In the BioFINDER cohort, 109 patients (33%) progressed to AD dementia. The performance of the clinical data model for prediction of progression to AD dementia was area under the curve (AUC) = 0.85 and four-year cognitive decline was R2 = 0.14. The performance was improved for both outcomes when adding hippocampal volume (AUC = 0.86, R2 = 0.16). Adding FreeSurfer brain regions improved prediction of four-year cognitive decline but not progression to AD (AUC = 0.83, R2 = 0.17), while the DL model worsened the performance for both outcomes (AUC = 0.84, R2 = 0.08). A sensitivity analysis showed that the Jacobian determinant image was more informative than the MRI image, but that performance was maximized when both were included. In the external evaluation cohort from ADNI, 23 patients (21%) progressed to AD dementia. The results for predicted progression to AD dementia were similar to the results for the BioFINDER test data, while the performance for the cognitive decline was deteriorated. Conclusions: The DL model did not significantly improve the prediction of clinical disease progression in AD, compared to regression models with a single pre-defined brain region.
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