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Search: WFRF:(Barrett M.) > (2015-2019)

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  • Locke, Adam E, et al. (author)
  • Genetic studies of body mass index yield new insights for obesity biology.
  • 2015
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401
  • Journal article (peer-reviewed)abstract
    • Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.
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  • Result 1-10 of 102
Type of publication
journal article (94)
conference paper (6)
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Type of content
peer-reviewed (97)
other academic/artistic (5)
Author/Editor
Evans, M. (10)
Brenner, H (7)
Salomaa, Veikko (7)
Kim, Jae-Young (7)
Halfvarson, Jonas, 1 ... (7)
Palotie, A (7)
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Akiyama, Kazunori (7)
Alberdi, Antxon (7)
Alef, Walter (7)
Ball, David (7)
Baloković, Mislav (7)
Barrett, John (7)
Bintley, Dan (7)
Blackburn, Lindy (7)
Brissenden, Roger (7)
Britzen, Silke (7)
Broderick, Avery E. (7)
Bronzwaer, Thomas (7)
Byun, Do Young (7)
Chan, Chi Kwan (7)
Chatterjee, Koushik (7)
Chen, Ming Tang (7)
Chen, Yongjun (7)
Christian, Pierre (7)
Conway, John, 1963 (7)
Cordes, James M. (7)
Cui, Yuzhu (7)
Davelaar, Jordy (7)
Dempsey, Jessica (7)
Desvignes, Gregory (7)
Eatough, Ralph P. (7)
Fromm, Christian M. (7)
Gammie, Charles F. (7)
Garcia, Roberto (7)
Gentaz, Olivier (7)
Georgiev, Boris (7)
Gu, Minfeng (7)
Hecht, Michael H. (7)
Ho, Luis C. (7)
Honma, Mareki (7)
Huang, Chih Wei L. (7)
Huang, Lei (7)
Ikeda, Shiro (7)
Inoue, Makoto (7)
James, David J. (7)
Jeter, Britton (7)
Jiang, Wu (7)
Johnson, Michael D. (7)
Jung, Taehyun (7)
Karami, Mansour (7)
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Karolinska Institutet (47)
Lund University (22)
University of Gothenburg (20)
Uppsala University (18)
Chalmers University of Technology (15)
Umeå University (8)
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Örebro University (8)
Stockholm University (4)
Linköping University (4)
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Luleå University of Technology (3)
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Swedish Museum of Natural History (1)
Swedish University of Agricultural Sciences (1)
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Language
English (102)
Research subject (UKÄ/SCB)
Medical and Health Sciences (50)
Natural sciences (33)
Engineering and Technology (2)
Social Sciences (1)
Humanities (1)

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