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Träfflista för sökning "WFRF:(Bass N.) srt2:(2010-2014)"

Search: WFRF:(Bass N.) > (2010-2014)

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1.	Lee, SH, et al. (author) Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs 2013 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:9, s. 984- Journal article (peer-reviewed)
2.	Sklar, P, et al. (author) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 2011 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:10, s. 977-U162 Journal article (peer-reviewed)
3.	Ripke, S, et al. (author) Genome-wide association study identifies five new schizophrenia loci 2011 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 43:10, s. 969-976 Journal article (peer-reviewed)
4.	Lenzini, P., et al. (author) Integration of genetic, clinical, and INR data to refine warfarin dosing 2010 In: Clinical Pharmacology and Therapeutics. - : Springer Science and Business Media LLC. - 0009-9236 .- 1532-6535. ; 87:5, s. 572-578 Journal article (peer-reviewed)abstract Well-characterized genes that affect warfarin metabolism (cytochrome P450 (CYP) 2C9) and sensitivity (vitamin K epoxide reductase complex 1 (VKORC1)) explain one-third of the variability in therapeutic dose before the international normalized ratio (INR) is measured. To determine genotypic relevance after INR becomes available, we derived clinical and pharmacogenetic refinement algorithms on the basis of INR values (on day 4 or 5 of therapy), clinical factors, and genotype. After adjusting for INR, CYP2C9 and VKORC1 genotypes remained significant predictors (P < 0.001) of warfarin dose. The clinical algorithm had an R(2) of 48% (median absolute error (MAE): 7.0 mg/week) and the pharmacogenetic algorithm had an R(2) of 63% (MAE: 5.5 mg/week) in the derivation set (N = 969). In independent validation sets, the R(2) was 26-43% with the clinical algorithm and 42-58% when genotype was added (P = 0.002). After several days of therapy, a pharmacogenetic algorithm estimates the therapeutic warfarin dose more accurately than one using clinical factors and INR response alone.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Andreassen, OA (3); Melle, I (3); Djurovic, S (3); Corvin, A (3); Gurling, H (3); Craddock, N (3); show more...; Mattheisen, M (3); Cichon, S (3); Nothen, MM (3); Rietschel, M (3); Schulze, TG (3); Ripke, S (3); Lichtenstein, P. (3); Kim, Y. (2); Li, J. (2); Schumacher, J. (2); Steinberg, S (2); Agartz, I (2); Day, R. (2); Xu, W (2); Raychaudhuri, S (2); Zhang, P (2); Sullivan, PF (2); Breen, G (2); Landén, Mikael, 1966 (2); Landen, M (2); Lathrop, M (2); Pato, CN (2); Pato, MT (2); Rujescu, D (2); St Clair, D (2); Werge, T (2); Hultman, CM (2); Stroup, TS (2); Lieberman, JA (2); OSBY, U (2); Ophoff, RA (2); Cahn, W (2); McMahon, FJ (2); Montgomery, GW (2); Morris, DW (2); Muhleisen, TW (2); Smoller, JW (2); Levinson, DF (2); Lucae, S (2); Backlund, L (2); Meier, S (2); Jones, L (2); Bauer, M (2); Datta, S (2); show less...

University: Karolinska Institutet (4); University of Gothenburg (2); Uppsala University (1)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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