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1.	Ferreira, Mjv, et al. (author) Poster Session 3 : Tuesday 5 May 2015, 08 2015 In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1 Journal article (peer-reviewed)
2.	Aboul-Enein, Mohamed N., et al. (author) Design and synthesis of novel stiripentol analogues as potential anticonvulsants 2012 In: European Journal of Medicinal Chemistry. - : Elsevier BV. - 0223-5234 .- 1768-3254. ; 47, s. 360-369 Journal article (peer-reviewed)abstract A series of stiripentol (SIP) analogues namely, 2-1(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7a-h, (+/-)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazole-1-carboxamides (+/-)-8a-h, and (+/-)-[(5RS)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazol-1-yl](aryl)methanones (+/-)-13a-f was synthesized by adopting appropriate synthetic routes and was pharmacologically evaluated in the preliminary anticonvulsant screens. The selected bioactive new chemical entities were subjected to ED50 determination and neurotoxicity evaluation. The most active congeners are 7h in MES screen and (+/-)-13b in scPTZ screen which displayed ED50 values of 87 and 110 mg/kg, respectively, as compared to that of STP (ED50 = 277.7 and 115 mg/kg in MES and scPTZ, respectively). (C) 2011 Elsevier Masson SAS. All rights reserved.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Hansen, E. (1); Costa, G. (1); Martin, J. (1); Keller, M. (1); Sörensen, Jens (1); Sorensen, J (1); show more...; Hassan, A (1); Soares, J (1); Abdel-Rehim, Mohamed (1); Abdelkader, M. (1); Aboul-Enein, Mohamed ... (1); El-Azzouny, Aida A. (1); Attia, Mohamed I. (1); Maklad, Yousreya A. (1); Amin, Kamilia M. (1); El-Behairy, Mohammed ... (1); Martinez, F. (1); Ramos, D (1); Patel, K (1); Jukema, J. W. (1); Foley, J (1); Mostafa, S (1); Sayed, S (1); Amin, A. (1); Yoshida, H (1); Bertuccio, G. (1); Kero, Tanja (1); Saraste, A. (1); Knuuti, J. (1); Cohen, M. (1); Tornos, P (1); Mushtaq, S (1); Bertella, E (1); Baggiano, A (1); Petulla', M (1); Conte, E (1); Andreini, D (1); Pontone, G (1); De Graaf, M A (1); Bax, J J (1); Scholte, A J (1); Thackeray, J T (1); Bengel, F M (1); Harms, H J (1); Tolbod, L P (1); Hansson, N H (1); Kim, W Y (1); Bouchelouche, K (1); Wiggers, H (1); Frokiaer, J (1); show less...

University: Uppsala University (1); Karlstad University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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