| 1. |
- Arnell, Henrik, et al.
(author)
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The genetics of primary nocturnal enuresis: inheritance and suggestion of a second major gene on chromosome 12q
- 1997
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In: Journal of Medical Genetics. - : BMJ. - 0022-2593 .- 1468-6244. ; 34:5, s. 360-5
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Journal article (peer-reviewed)abstract
- Primary nocturnal enuresis (PNE), or bedwetting at night, affects approximately 10% of 6 year old children. Genetic components contribute to the pathogenesis and recently one locus was assigned to chromosome 13q. We evaluated the genetic factors and the pattern of inheritance for PNE in 392 families. Dominant transmission was observed in 43% and an apparent recessive mode of inheritance was observed in 9% of the families. Among the 392 probands the ratio of males to females was 3:1 indicating sex linked or sex influenced factors. Linkage to candidate regions was tested in 16 larger families segregating for autosomal dominant PNE. A gene for PNE was excluded from chromosome 13q in 11 families, whereas linkage to the interval D13S263-D13S291 was suggested (Zmax = 2.1) in three families. Further linkage analyses excluded about 1/3 of the genome at a 10 cM resolution except the region around D12S80 on chromosome 12q that showed a positive two point lod score in six of the families (Zmax = 4.2). This locus remains suggestive because the material was not sufficiently large to give evidence for heterogeneity. Our pedigree analysis indicates that major genes are involved in a large proportion of PNE families and the linkage results suggest that such a gene is located on chromosome 12q.
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| 2. |
- Abdel-Motal, Ussama M., et al.
(author)
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Major histocompatibility complex class I binding glycopeptides for the estimation of 'empty' class I molecules
- 1995
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In: Journal of Immunological Methods. - : Elsevier BV. - 0022-1759. ; 188:1, s. 21-31
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Journal article (peer-reviewed)abstract
- Different forms of major histocompatibility complex (MHC) class I heavy chains are known to be expressed on the cell surface, including molecules which are functionally 'empty'. Direct peptide binding to cells is obvious during sensitization of target cells in vitro for cytotoxic T lymphocyte killing and 'empty' MHC-I molecules are comparatively abundant on TAP- 1 2 peptide transporter mutant cells. In the present work we have estimated the fraction of 'empty' MHC class I molecules using glycosylated peptides and cellular staining with carbohydrate specific monoclonal antibodies. Synthetic Db and Kb binding peptides were coupled at different positions with different di- or trisaccharides, using different spacing between the carbohydrate and the peptide backbone. Binding of sugar specific mAbs was compared in ELISA and cellular assays. An optimal Db binding glycopeptide was used for comparative staining with anti-Db and anti-carbohydrate monoclonal antibodies to estimate fractions of 'empty' molecules on different T lymphoid cells. On activated normal T cells, a large fraction of Db molecules were found to be 'empty'. The functional cole of such 'empty' MHC class I molecules on T cells is presently unclear. However, on antigen presenting cells they might participate in the antigen presentation process.
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| 3. |
- Ahlqwist, M, et al.
(author)
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Concentrations of blood, serum and urine components in relation to number of amalgam tooth fillings in Swedish women
- 1995
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In: Community dentistry and oral apidemiology. ; 23, s. 217-221
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Journal article (peer-reviewed)abstract
- Department of Oral Diagnostic Radiology, Sahlgrenska Hospital, Göteborg University, Gothenburg, Sweden. Altogether 1462 women aged 38, 46, 50, 54 and 60 yr were examined in 1968/69 in a combined medical and dental population study in Gothenburg, Sweden. Number of tooth surfaces restored with amalgam fillings was assessed. The examination was repeated in 1980/81 including a new dental examination. The results from a number of biochemical analyses of blood, serum and urine were analyzed for a possible statistical relationship to number of dental amalgam fillings. As emphasis has been put in the literature on special influence from amalgam on kidney function and on the immunological system, special attention was paid to variables which might reflect these functions in our analyses. When potential confounders were taken into consideration, no significant correlations remained which seemed to be of clinical importance. Specifically, amalgam fillings were not found to be associated with impairment of the kidney function or the immunological status. PMID: 7587142 [PubMed - indexed for MEDLINE]
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| 4. |
- Andersson, H. Ingemar, 1950-
(author)
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Chronic pain : epidemiological studies in a general population
- 1998
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Doctoral thesis (other academic/artistic)abstract
- The aim was to study the epidemiology of chronic pain (> 3 months duration) and factors associated to pain prevalence, prognosis, health care and medication in a general population. A cross-sectional mailed survey to a random population sample (n = 1806) was followed by a clinical examination and a prospective study of three selected groups. Pain related diagnoses from primary health care was monitored and compared with pain prevalence. The most important findings were: - a high total prevalence of chronic pain, 55.2%, without gender difference but varying by age and socioeconomic level. About one fourth (12.8%) reported high pain intensity and functional impairments. Women experienced pain at more locations and with higher intensity. - in a multivariate analysis increasing age, female gender, low education, high work strain, depression and insomnia were associated with chronic pain. - widespread pain showed a worse 2- year prognosis compared with neck shoulder pain. - musculoskeletal location of pain dominated, myalgia and myofascial pain being the most common symptom descriptions. - co-morbidity with chronic pain was common. More hypertensives and an increased level of serum uric acid associated to widepread pain indicated possible metabolic connections to pain. - smoking (current and previous) was associated with low-back and widespread pain. - chronic pain had a substantial influence of primary health care-seeking and medication; high pain intensity being the most important predictor of care and medication. - pain related diagnoses in primary health care increased between 1987 and 1996. Chronic pain, mainly with musculoskeletal location, is a community health problem. A multi-factorial approach in prevention and treatment on the basis of present knowledge is necessary.
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| 5. |
- Bengtsson, Lars-Göran
(author)
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Övertändning, backdraft och brandgasexplosion sett ur räddningstjänstens perspektiv
- 1999
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Licentiate thesis (other academic/artistic)abstract
- This report presents a detailed description of the phenomena flashover, backdraft and smoke gas explosion. The physical and chemical processes which are involved in these phenomena are thoroughly discussed. The report also describes a number of compartment fire scenarios which are believed to be the most common scenarios occurring in Sweden. The description is based on a number of full- scale experiments which were carried out within the project. At the end of the report, possible warning signs of a potential flashover and backdraft are discussed. In the appendices, a number of models used to predict flashover are evaluated, using data from small scale experiments carried out within the project.
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| 6. |
- Bengtsson, Staffan, 1955-, et al.
(author)
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K-märkt : ett 50-talsprojekt
- 1995
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In: Kulturmiljövård. - Stockholm : Riksantikvarieämbetet. - 1100-4800. ; :1-2, s. 122-125
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Journal article (pop. science, debate, etc.)abstract
- I en Volvo Amazon och med en god portion nostalgi med i bagaget gav sig K-spanarna Staffan Bengtsson och Göran Willis ut på jakt efter 1900-talets nya mötesplatser. De hittade bensinstationer, biografer, folkets parker och konditorier - genuina miljöer från 1950-talet, sin egen uppväxttid.
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| 7. |
- Bengtsson, Staffan, 1955-, et al.
(author)
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Modärna tider
- 1996
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In: Kulturmiljövård. - Stockholm : Riksantikvarieämbetet. - 1100-4800. ; :1-2, s. 67-70
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Journal article (pop. science, debate, etc.)
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| 8. |
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| 9. |
- Singh, V.P., et al.
(author)
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Kinematic wave modelling of saturated basal flow in a snowpack
- 1997
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In: Hydrological Processes. - 0885-6087 .- 1099-1085. ; 11:2, s. 177-187
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Journal article (peer-reviewed)abstract
- Movement of snowmelt water through a thin saturated layer at the infiltrating base of a snowpack is modelled by applying the kinematic wave theory. Analytical solutions are obtained for flow depth, velocity and discharge assuming that the rate of input to the saturated layer due to vertical percolation is constant. This assumption results in a linear rise and recession of the snowmelt hydrograph. The solutions are extended to the case of time-varying input. An explicit consideration of infiltration leads to a free boundary problem.
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| 10. |
- Singh, V.P., et al.
(author)
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Kinematic wave modelling of vertical movement of snowmelt water through a snowpack
- 1997
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In: Hydrological Processes. - 0885-6087 .- 1099-1085. ; 11:2, s. 149-167
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Journal article (peer-reviewed)abstract
- Vertical movement of snowmelt water through snowpacks is modelled by applying the kinematic wave theory. Analytical solutions are obtained for moisture flux, particle velocity, time history and velocity of meltwater front and total moisture content for a single melt event assuming that the melt rate is constant. These solutions are extended to the case involving more than one event.
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