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Träfflista för sökning "WFRF:(Berglund Per) srt2:(1995-1999)"

Search: WFRF:(Berglund Per) > (1995-1999)

  • Result 1-10 of 22
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  • Berglund, Olof, et al. (author)
  • Factors influencing organochlorine uptake in age-0 brown trout (Salmo trutta) in lotic environments
  • 1997
  • In: Canadian Journal of Fisheries and Aquatic Sciences. - 1205-7533. ; 54:12, s. 2767-2774
  • Journal article (peer-reviewed)abstract
    • In 1994 and 1995, we investigated the relationship between stream morphology and water chemistry and levels of organochlorines (HCB, PCB, and DDT) in young-of-the-year brown trout (Salmo trutta) from 25 streams in southern Sweden. Contrary to earlier findings for lakes, we found a positive relationship between trophic status (total phosphorus) and uptake of persistent pollutants in stream biota (trout). This difference between benthic, stream environments and pelagic, lake environments may be related to processes affecting pollutant uptake, i.e., pollutant "spiralling" or the shift from heterotrophy to autotrophy in streams. Land use in the catchment area of the streams also affected pollutant levels in trout, with higher levels in agricultural landscapes and lower levels in forested areas. Size of catchment area, however, did not influence uptake of pollutants in trout. The results indicate that eutrophication of streams by agricultural activities and excessive nutrient loading may increase uptake of persistent pollutants in stream biota.
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  • Berglund, Per, et al. (author)
  • Reversed enantiopreference of Candida rugosa lipase supports different modes of binding enantiomers of a chiral acyl donor
  • 1998
  • In: Journal of Molecular Catalysis - B Enzymatic. - 1381-1177 .- 1873-3158. ; 5:1-4, s. 283-287
  • Journal article (peer-reviewed)abstract
    • Molecular modelling identifies two different productive modes of binding the enantiomers of a 2-methyldecanoic acid ester to the active site of Candida rugosa lipase (CRL). The fast reacting S-enantiomer occupies the previously identified acyl-binding tunnel of the enzyme, whereas the R- enantiomer leaves the tunnel empty. The modelling suggested that if both enantiomers were forced to bind to the active site leaving the tunnel empty, the enzyme would reverse its enantiopreference to become R-enantioselective. To test this hypothesis, we designed a structural analogue to 2- methyldecanoic acid, 2-methyl-6-(2-thienyl)hexanoic acid, which was expected to be too bulky to fit its acyl moiety into the acyl-binding tunnel. The CRL- catalysed hydrolysis of the ethyl ester of this substrate resulted in the preferential conversion of the R-enantiomer as predicted by molecular modelling. This represents the first kinetic evidence supporting the existence of two different modes of binding the enantiomers of a 2- methyldecanoic acid ester to the active site of CRL. We have shown that a rational 3D based approach in combination with substrate engineering can be used to predict and control the stereochemical outcome of a lipase catalysed reaction.
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  • Berglund, Per, et al. (author)
  • Switched enantiopreference of Humicola lipase for 2-phenoxyalkanoic acid ester homologs can be rationalized by different substrate binding modes
  • 1999
  • In: Tetrahedron. - 0957-4166 .- 1362-511X. ; 10:21, s. 4191-4202
  • Journal article (peer-reviewed)abstract
    • Humicola lanuginosa lipase was used for enantioselective hydrolyses of a series of homologous 2-phenoxyalkanoic acid ethyl esters. The enantioselectivity (E-value) of the enzyme changed from an (R)-enantiomer preference for the smallest substrate, 2-phenoxypropanoic acid ester, to an (S)-enantiomer preference for the homologous esters with longer acyl moieties. The E-values span the range from E=13 (R) to E=56 (S). A molecular modeling study identified two different substrate-binding modes for each enantiomer. We found that the enantiomers favored different modes. This discovery provided a model that offered a rational explanation for the observed switch in enantioselectivity. (C) 1999 Elsevier Science Ltd. All rights reserved.
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  • Result 1-10 of 22
Type of publication
journal article (19)
reports (1)
book (1)
doctoral thesis (1)
Type of content
peer-reviewed (17)
other academic/artistic (3)
pop. science, debate, etc. (2)
Author/Editor
Larsson, Per (8)
Berglund, Per (6)
Berglund, O (5)
Eklöv, A. (5)
Berglund, Lars (4)
Brönmark, C. (4)
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Greenberg, Larry (4)
Lithell, Hans (3)
Berglund, Olof (3)
Andersson, Per-Erik (3)
Reneland, Richard (3)
Eklöv, Anders (3)
Brönmark, Christer (2)
Lind, L (2)
Greenberg, L (2)
Hult, Karl (2)
Glimelius, Bengt (1)
Hansson, Bengt (1)
Holmberg, Lars (1)
Gerdner, Arne (1)
Lind, Lars (1)
Nilsson, Anders (1)
Berglund, Mats (1)
Persson, Anders (1)
Okla, Lennart (1)
Bremle, Gudrun (1)
Backe, Cecilia (1)
Okla, L (1)
Backe, C (1)
Sjödén, Per-Olow (1)
Johansson, Birgitta (1)
Persson, A. (1)
Jensen, M (1)
Engström, Per (1)
Edlund, Håkan (1)
Högberg, Hans-Erik (1)
Hedenström, Erik (1)
Berglund, Bo (1)
Hänni, Arvo (1)
Landin, Anne (1)
Berglund, Gunilla (1)
Holmquist, M (1)
Berglund, Annica, 19 ... (1)
Brelid, Harald, 1960 (1)
Rindby, Anders, 1951 (1)
Holmquist, Mats Tors ... (1)
DeSantis, Grace (1)
Stabile, Michele R. (1)
Shang, Xiao (1)
Gold, Marvin (1)
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University
Royal Institute of Technology (6)
Linnaeus University (6)
Uppsala University (5)
Lund University (4)
Karlstad University (3)
Jönköping University (1)
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Mid Sweden University (1)
Chalmers University of Technology (1)
Karolinska Institutet (1)
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Language
English (21)
Swedish (1)
Research subject (UKÄ/SCB)
Natural sciences (10)
Engineering and Technology (4)
Medical and Health Sciences (2)
Social Sciences (1)

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