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Träfflista för sökning "WFRF:(Bergman A) "

Search: WFRF:(Bergman A)

  • Result 1-10 of 983
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  • Justice, A. E., et al. (author)
  • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
  • 2017
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Journal article (peer-reviewed)abstract
    • Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
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  • Graff, M., et al. (author)
  • Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
  • 2017
  • In: PLoS Genet. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 13:4
  • Journal article (peer-reviewed)abstract
    • Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
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  • Vogel, Jacob W., et al. (author)
  • Four distinct trajectories of tau deposition identified in Alzheimer’s disease
  • 2021
  • In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 27:5, s. 871-881
  • Journal article (peer-reviewed)abstract
    • Alzheimer’s disease (AD) is characterized by the spread of tau pathology throughout the cerebral cortex. This spreading pattern was thought to be fairly consistent across individuals, although recent work has demonstrated substantial variability in the population with AD. Using tau-positron emission tomography scans from 1,612 individuals, we identified 4 distinct spatiotemporal trajectories of tau pathology, ranging in prevalence from 18 to 33%. We replicated previously described limbic-predominant and medial temporal lobe-sparing patterns, while also discovering posterior and lateral temporal patterns resembling atypical clinical variants of AD. These ‘subtypes’ were stable during longitudinal follow-up and were replicated in a separate sample using a different radiotracer. The subtypes presented with distinct demographic and cognitive profiles and differing longitudinal outcomes. Additionally, network diffusion models implied that pathology originates and spreads through distinct corticolimbic networks in the different subtypes. Together, our results suggest that variation in tau pathology is common and systematic, perhaps warranting a re-examination of the notion of ‘typical AD’ and a revisiting of tau pathological staging. © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
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  • Result 1-10 of 983
Type of publication
journal article (776)
conference paper (141)
other publication (23)
research review (17)
reports (13)
book chapter (9)
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doctoral thesis (2)
editorial collection (1)
book (1)
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Type of content
peer-reviewed (791)
other academic/artistic (188)
pop. science, debate, etc. (4)
Author/Editor
Bergman, P. (92)
Bergman, A (74)
Bergman, U (68)
Groop, Leif (36)
Bergman, Peder (35)
Bergman, T (33)
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Tuomilehto, Jaakko (32)
Boehnke, Michael (31)
Bergman, Richard N (31)
Mohlke, Karen L (30)
Bergman, Peder, 1961 ... (30)
Collins, Francis S. (30)
Bergman, B (29)
Jackson, Anne U. (29)
McCarthy, Mark I (28)
Bergman, J. (28)
Toropov, A.A. (28)
Wareham, Nicholas J. (27)
Laakso, Markku (27)
Stringham, Heather M (27)
Kuusisto, Johanna (26)
Barroso, Ines (25)
Prokopenko, Inga (25)
Bonnycastle, Lori L. (24)
Lind, Lars (23)
Lyssenko, Valeriya (22)
Langenberg, Claudia (22)
Ingelsson, Erik (22)
Lindgren, Cecilia M. (22)
Fatouros-Bergman, H. (22)
Monemar, Bo (21)
Tuomi, Tiinamaija (20)
Salomaa, Veikko (20)
Monemar, Bo, 1942- (20)
Bergman, Åke (20)
Gieger, Christian (20)
Bergman, O (20)
Bergman, Anders (20)
Loos, Ruth J F (20)
Frayling, Timothy M (20)
Scott, Laura J (20)
Bergman, Stefan (19)
Bjorkhem-Bergman, L (19)
Stefansson, Kari (19)
Abecasis, Goncalo R. (19)
Luan, Jian'an (19)
Dupuis, Josée (19)
Illig, Thomas (19)
Grallert, Harald (19)
Morris, Andrew P. (19)
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University
Karolinska Institutet (519)
Uppsala University (176)
Lund University (118)
University of Gothenburg (102)
Linköping University (93)
Umeå University (84)
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Stockholm University (61)
Chalmers University of Technology (34)
Royal Institute of Technology (32)
Örebro University (29)
Södertörn University (29)
Karlstad University (27)
Linnaeus University (20)
RISE (17)
Halmstad University (13)
Jönköping University (12)
Luleå University of Technology (5)
Högskolan Dalarna (5)
Mid Sweden University (4)
Swedish Museum of Natural History (4)
Swedish Environmental Protection Agency (3)
Swedish University of Agricultural Sciences (3)
University of Skövde (2)
University of Gävle (1)
Stockholm School of Economics (1)
University of Borås (1)
Blekinge Institute of Technology (1)
VTI - The Swedish National Road and Transport Research Institute (1)
IVL Swedish Environmental Research Institute (1)
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Language
English (959)
Swedish (19)
Undefined language (5)
Research subject (UKÄ/SCB)
Medical and Health Sciences (238)
Natural sciences (175)
Social Sciences (47)
Engineering and Technology (25)
Agricultural Sciences (5)
Humanities (2)

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