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- Bergman, Kerstin
(author)
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En möjlig värld: En tematisk studie av Lars Gustafssons 1990-talsromaner
- 2002
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Doctoral thesis (other academic/artistic)abstract
- "En möjlig värld" explores how questions of moral standards and ontology are discussed explores how questions of moral standards and ontology are discussed and represented in three of Lars Gustafsson's novels in a search for a world that is conceivable - in terms of moral philosophy, as well as ontology. Initially, a theoretical foundation is constructed, based on the assumption that fictional texts are linguistic phenomena that mainly refer to the worlds they themselves create. By establishing these fictional worlds, and by relating them to the experience-based world, the reader construes the meaning(s) of the text. This theoretical model constitutes a prerequisite for identifying that the worlds in Gustafsson's novels go through fundamental ontological changes, changes that constitute the peaks and turning points of their thematic developments. A thematic line is found to run through the three novels: In "Historien med hunden" (1993), the theodicy problem turns out to be unsolvable in the Jewish-Christian, monotheistic ontology, and a search for a new ontology that could provide a logically acceptable foundation for universally relevant moral standards, begins. Eventually, a dualistic Gnostic ontology, is established. Unfortunately, in the Gnostic world of "Tjänarinnan" (1996), the individual turns out to be lonely, alienated, and fragmented. A solution to this problem is found as the Gnostic view of the world is replaced by a monistic ontology. "Windy berättar" (1999) explores the question of what death is in such a monistic ontology where each individual thing is part of the same whole. Spinoza's concept of death as a constant process of change, and as a constitutive part of life, is presented, and the novel ends with the realization that after coming to terms with what death really is, one has to stop thinking about the past and start living in the present. Finally, in the concluding chapter of "En möjlig värld", a context of pre-Millennial a context of pre-Millennial beliefs and expressions is delineated. It is shown how Gustafsson's novels relate to this context, as well as to the tradition of literary Apocalypse. Also the positive function of the Apocalypse as the means to a new beginning, or rebirth, is discussed and compared to the destruction, and construction, of ontological foundations for the worlds of the novels.
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- Bergman, Kerstin, et al.
(author)
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Ontologiska rum i Lars Gustafssons Tjänarinnan
- 2000
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In: Nordisk litteratur og mentalitet : foredrag fra den 22. studiekongres i International Association for Scandinavian studies (IASS) ( Annales Societatis Scientiarum Faeroensis.). - 9991841253 ; Suppl. 25, s. 123-133
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Book chapter (other academic/artistic)abstract
- About ontological rooms in Lars Gustafssons novel Tjänarinnan (1996).
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- Bergman, Kerstin, et al.
(author)
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Ska vi äta våra döda: Linné mellan tro och nytta
- 2002
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In: I ordets smedja: Festskrift till Per Rydén. - 9172034947 ; , s. 182-191
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Book chapter (other academic/artistic)abstract
- About the struggle between faith and utilitarian aspects in the writings of Carl von Linné.
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- Bergman, Kerstin, et al.
(author)
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Smärtan vidgar världen
- 2003
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In: Vidgade sinnen. - 9157804354 ; , s. 71-86
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Book chapter (other academic/artistic)abstract
- About the concept of pain in Lars Gustafsson’s novel "En biodlares död" (1978).
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- Jönsson-Videsäter, Kerstin, et al.
(author)
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Selenite-induced apoptosis in doxorubicin-resistant cells and effects on the thioredoxin system.
- 2004
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In: Biochemical Pharmacology. - : Elsevier BV. - 0006-2952. ; 67:3, s. 513-522
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Journal article (peer-reviewed)abstract
- Selenium treatment of the doxorubicin-resistant cell line, U-1285dox, derived from human small cell carcinoma of the lung, resulted in massive apoptosis. This effect appeared maximal at 2 days after addition of selenite. The apoptosis was caspase-3 independent as revealed by Western blot analysis, activity measurement and by using caspase inhibitors. Induction of apoptosis was significantly more pronounced and occurred after addition of lower concentrations of selenite in the doxorubicin-resistant cells compared to the parental doxorubicin-sensitive cells. High levels of selenite caused necrosis in the doxorubicin-sensitive cells. Analysis of enzymatic activity (insulin reduction) of thioredoxin reductase (TrxR) and TrxR protein concentration, measured by ELISA, revealed increasing activity and protein levels after treatment with increasing concentrations of selenium. Maximum relative increase was induced up to 1 μM in both sublines and at this selenium level the concentrations of TrxR measured as insulin reducing activity or ELISA immunoreactivity were nearly identical. Increasing concentrations of selenite up to 10 μM resulted in increased activity and concentration of TrxR in the sensitive subline but decreasing levels in the resistant subline. The level of truncated Trx (tTrx) was higher in the resistant U-1285dox cells but the level did not change with increasing selenite concentrations. Our results demonstrate pronounced selective selenium-mediated apoptosis in therapy-resistant cells and suggest that redox regulation through the thioredoxin system is an important target for cancer therapy.
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