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Träfflista för sökning "WFRF:(Boeckxstaens Guy) srt2:(2015-2019)"

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1.	Ek, Weronica E, et al. (author) Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. 2015 In: Gut. - : BMJ. - 1468-3288 .- 0017-5749. ; 64, s. 1774-1782 Journal article (peer-reviewed)abstract IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.
2.	Garcia-Etxebarria, Koldo, et al. (author) Increased Prevalence of Rare Sucrase-isomaltase Pathogenic Variants in Irritable Bowel Syndrome Patients 2018 In: Clinical Gastroenterology and Hepatology. - : ELSEVIER SCIENCE INC. - 1542-3565 .- 1542-7714. ; 16:10, s. 1673-1676 Journal article (other academic/artistic)abstract n/a
3.	Lenz, Tobias L., et al. (author) Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases 2015 In: Nature Genetics. - : Macmillan Publishers Ltd.. - 1061-4036 .- 1546-1718. ; 47:9, s. 1085-1090 Journal article (peer-reviewed)abstract Human leukocyte antigen (HLA) genes confer substantial risk for autoimmune diseases on a log-additive scale. Here we speculated that differences in autoantigen-binding repertoires between a heterozygote's two expressed HLA variants might result in additional non-additive risk effects. We tested the non-additive disease contributions of classical HLA alleles in patients and matched controls for five common autoimmune diseases: rheumatoid arthritis (n(cases) = 5,337), type 1 diabetes (T1D; n(cases) = 5,567), psoriasis vulgaris (n(cases) = 3,089), idiopathic achalasia (n(cases) = 727) and celiac disease (ncases = 11,115). In four of the five diseases, we observed highly significant, non-additive dominance effects (rheumatoid arthritis, P = 2.5 x 10(-12); T1D, P = 2.4 x 10(-10); psoriasis, P = 5.9 x 10(-6); celiac disease, P = 1.2 x 10(-87)). In three of these diseases, the non-additive dominance effects were explained by interactions between specific classical HLA alleles (rheumatoid arthritis, P = 1.8 x 10(-3); T1D, P = 8.6 x 10(-27); celiac disease, P = 6.0 x 10(-100)). These interactions generally increased disease risk and explained moderate but significant fractions of phenotypic variance (rheumatoid arthritis, 1.4%; T1D, 4.0%; celiac disease, 4.1%) beyond a simple additive model.

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Type of publication: journal article (3)

Type of content: peer-reviewed (2); other academic/artistic (1)

Author/Editor: Simrén, Magnus, 1966 (2); Ohlsson, Bodil (2); Lindberg, Greger (2); Karling, Pontus (2); Schmidt, Peter T. (2); D'Amato, Mauro (2); show more...; Walter, Susanna (2); Franke, Andre (2); Dlugosz, Aldona (2); Bellini, Massimo (2); Barbara, Giovanni (2); Camilleri, Michael (2); Törnblom, Hans, 1966 (1); Martin, Javier (1); van Heel, David A (1); Gregersen, Peter K. (1); Klareskog, Lars (1); Talley, Nicholas J. (1); Agréus, Lars (1); Andreasson, Anna (1); Burwinkel, Barbara (1); Pedersen, Nancy L (1); Ek, Weronica E (1); Rahman, Proton (1); Worthington, Jane (1); Gladman, Dafna D. (1); Tsoi, Lam C. (1); Jonkers, Daisy (1); Daly, Mark J. (1); Zucchelli, Marco (1); Bresso, Francesca (1); Schumacher, Johannes (1); Rich, Stephen S (1); Wijmenga, Cisca (1); de Bakker, Paul I. W ... (1); Rantapää-Dahlqvist, ... (1); Assadi, Ghazaleh (1); Bonfiglio, Ferdinand ... (1); Magnusson, Patrik (1); Gockel, Ines (1); Holliday, Elizabeth ... (1); Mayer, Emeran A. (1); Gazouli, Maria (1); Nardone, Gerardo (1); Cuomo, Rosario (1); Usai-Satta, Paolo (1); Galeazzi, Francesca (1); Neri, Matteo (1); Portincasa, Piero (1); Ripke, Stephan (1); show less...

University: Umeå University (3); Karolinska Institutet (3); University of Gothenburg (2); Linköping University (2); Lund University (2); Uppsala University (1); show more...; Stockholm University (1); show less...

Language: English (3)

Research subject (UKÄ/SCB): Medical and Health Sciences (3)

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