| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Cardone, Monica, et al.
(author)
-
The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis.
- 2005
-
In: Mol Cell Biol. - 0270-7306. ; 25:6, s. 2395-405
-
Journal article (peer-reviewed)abstract
- The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.
|
|
| 5. |
- Dham, A., et al.
(author)
-
The Determination of Bound Water in Waste Phosphatic Clay
- 2009
-
In: Research Letters in Materials Science. - : Hindawi Limited. - 1687-6822 .- 1687-6830.
-
Journal article (peer-reviewed)abstract
- Phosphatic clay is a by-product of phosphate strip mining, particularly in Florida, USA. This waste material occupies about 100000 acres of land which could be utilized for other causes. Thus, its use as an alternating cementing material for the addition into the mixing matrix of cement paste and concrete to yield higher strength would be profitable for both materials involved. But the biggest drawback faced is that the phosphatic claypossesses high water holding capacity. The water is thus not available for mixing purposes when added to cement paste and concrete and is thus known as bound water. It is therefore essential to determine the amount of bound water to phosphatic clay which shall not be available for the hydration reaction of cement in cement paste and concrete.
|
|
| 6. |
- Stephens, P. A., et al.
(author)
-
The scaling of diving time budgets: Insights from an optimality approach
- 2008
-
In: American Naturalist. - : University of Chicago Press. - 0003-0147 .- 1537-5323. ; 171:3, s. 305-314
-
Journal article (peer-reviewed)abstract
- Simple scaling arguments suggest that, among air-breathing divers, dive duration should scale approximately with mass to the one-third power. Recent phylogenetic analyses appear to confirm this. The same analyses showed that duration of time spent at the surface between dives has scaling very similar to that of dive duration, with the result that the ratio of dive duration to surface pause duration is approximately mass invariant. This finding runs counter to other arguments found in the diving literature that suggest that surface pause duration should scale more positively with mass, leading to a negative scaling of the dive-pause ratio. We use a published model of optimal time allocation in the dive cycle to show that optimal decisions can predict approximate mass invariance in the dive-pause ratio, especially if metabolism scales approximately with mass to the two-thirds power (as indicated by some recent analyses) and oxygen uptake is assumed to have evolved to supply the body tissues at the required rate. However, emergent scaling rules are sensitive to input parameters, especially to the relationship between the scaling of metabolism and oxygen uptake rate at the surface. Our results illustrate the utility of an optimality approach for developing predictions and identifying key areas for empirical research on the allometry of diving behavior.
|
|
| 7. |
- Akre, Olof, et al.
(author)
-
Maternal and gestational risk factors for hypospadias
- 2008
-
In: Journal of Environmental Health Perspectives. - : Environmental Health Perspectives. - 0091-6765 .- 1552-9924. ; 116:8, s. 1071-1076
-
Journal article (peer-reviewed)abstract
- BACKGROUND: An increase in the prevalence of hypospadias has been reported, but the environmental causes remain virtually unknown. OBJECTIVES: Our goal was to assess the association between risk of hypospadias and indicators of placental function and endogenous hormone levels, exposure to exogenous hormones, maternal diet during pregnancy, and other environmental factors. METHODS: We conducted a case-control study in Sweden and Denmark from 2000 through 2005 using self-administered questionnaires completed by mothers of hypospadias cases and matched controls. The response rate was 88% and 81% among mothers of cases and controls, respectively. The analyses included 292 cases and 427 controls. RESULTS: A diet during pregnancy lacking both fish and meat was associated with a more than 4-fold increased risk of hypospadias [odds ratio (OR) 4.6, 95% confidence interval (CI), 1.6-13.3]. Boys born to obese [body mass index (BMI) > ;= 30] women had a more than 2-fold increased risk of hypospadias (OR = 2.6, 95% CI, 1.2-5.7) compared with boys born to mothers with a normal weight (BMI = 20-24). Maternal hypertension during pregnancy and absence of maternal nausea increased a boy's risk of hypospadias 2.0-fold (95% CI, 1.1-3.7) and 1.8-fold (95% CI, 1.2-2.8), respectively. Nausea in late pregnancy also appeared to be positively associated with hypospadias risk (OR = 7.6, 95% CI, 1.1-53). CONCLUSIONS: A pregnancy diet lacking meat and fish appears to increase the risk of hypospadias in the offspring. Other risk associations were compatible with a role for placental insufficiency in the etiology of hypospadias.
|
|
| 8. |
|
|
| 9. |
- Hedenqvist, Mikael S., et al.
(author)
-
Morphology and diffusion properties of whey/montmorillonite nanocomposites
- 2006
-
In: Composites Science And Technology. - : Elsevier BV. - 0266-3538 .- 1879-1050. ; 66:13, s. 2350-2359
-
Journal article (peer-reviewed)abstract
- The diffusion of methanol in solution-cast whey-protein-isolate/poly(vinylidene pyrrolidone)-coated montmorillonite composite films was studied. The filler content was 0-4.8 vol%. Desorption experiments on samples saturated in methanol were conducted in a nitrogen-purged chamber at 294 K or in a thermogravimeter at 333, 348 and 363 K. The desorption curves were fitted using a two-phase diffusion model; where diffusion occurred first in the rubbery and later in the glassy state. A free volume model was used to analyze desorption at 363 K which occurred only within the rubbery phase and it enabled the geometrical impedance factor and free volume constraints from the nanoparticles to be assessed. Transmission electron microscopy showed a partial exfoliation of the nanoparticles. The geometrical impedance factor increased markedly with increasing filler content in accordance with the high aspect ratio of the nanoparticle aggregates. Transmission electron microscopy, in combination with model calculations, revealed that the clay sheets were oriented preferentially in the plane of the film which was an important factor underlying the high geometrical impedance factor obtained for the nanocomposites. A small but significant reduction in the fractional free volume of the polymer matrix was observed for the rubbery polymer in the presence of montmorillonite.
|
|
| 10. |
|
|
