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Träfflista för sökning "WFRF:(Brunner E) srt2:(2020-2024)"

Search: WFRF:(Brunner E) > (2020-2024)

  • Result 1-10 of 59
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  • Bravo, L, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Tabiri, S, et al. (author)
  • 2021
  • swepub:Mat__t
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  • Hageman, S., et al. (author)
  • SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe
  • 2021
  • In: European Heart Journal. - : Oxford University Press (OUP). - 0195-668X .- 1522-9645. ; 42:25, s. 2439-2454
  • Journal article (peer-reviewed)abstract
    • Aims The aim of this study was to develop, validate, and illustrate an updated prediction model (SCORE2) to estimate 10-year fatal and non-fatal cardiovascular disease (CVD) risk in individuals without previous CVD or diabetes aged 40-69 years in Europe. Methods and results We derived risk prediction models using individual-participant data from 45 cohorts in 13 countries (677 684 individuals, 30 121 CVD events). We used sex-specific and competing risk-adjusted models, including age, smoking status, systolic blood pressure, and total- and HDL-cholesterol. We defined four risk regions in Europe according to country-specific CVD mortality, recalibrating models to each region using expected incidences and risk factor distributions. Region-specific incidence was estimated using CVD mortality and incidence data on 10 776 466 individuals. For external validation, we analysed data from 25 additional cohorts in 15 European countries (1 133 181 individuals, 43 492 CVD events). After applying the derived risk prediction models to external validation cohorts, C-indices ranged from 0.67 (0.65-0.68) to 0.81 (0.76-0.86). Predicted CVD risk varied several-fold across European regions. For example, the estimated 10-year CVD risk for a 50-year-old smoker, with a systolic blood pressure of 140 mmHg, total cholesterol of 5.5 mmol/L, and HDL-cholesterol of 1.3 mmol/L, ranged from 5.9% for men in low- risk countries to 14.0% for men in very high-risk countries, and from 4.2% for women in low-risk countries to 13.7% for women in very high-risk countries. Conclusion SCORE2-a new algorithm derived, calibrated, and validated to predict 10-year risk of first-onset CVD in European populations-enhances the identification of individuals at higher risk of developing CVD across Europe.
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  • Aalbers, Jelle, et al. (author)
  • Solar neutrino detection sensitivity in DARWIN via electron scattering
  • 2020
  • In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 80:12
  • Journal article (peer-reviewed)abstract
    • We detail the sensitivity of the proposed liquid xenon DARWIN observatory to solar neutrinos via elastic electron scattering. We find that DARWIN will have the potential to measure the fluxes of five solar neutrino components: pp, 7Be, 13N, 15O and pep. The precision of the 13N, 15O and pep components is hindered by the double-beta decay of 136Xe and, thus, would benefit from a depleted target. A high-statistics observation of pp neutrinos would allow us to infer the values of the electroweak mixing angle, sin2 theta w, and the electron-type neutrino survival probability, Pee, in the electron recoil energy region from a few keV up to 200 keV for the first time, with relative precision of 5% and 4%, respectively, with 10 live years of data and a 30 tonne fiducial volume. An observation of pp and 7Be neutrinos would constrain the neutrino-inferred solar luminosity down to 0.2%. A combination of all flux measurements would distinguish between the high- (GS98) and low-metallicity (AGS09) solar models with 2.1-2.5 sigma significance, independent of external measurements from other experiments or a measurement of 8B neutrinos through coherent elastic neutrino-nucleus scattering in DARWIN. Finally, we demonstrate that with a depleted target DARWIN may be sensitive to the neutrino capture process of 131Xe.
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  • Result 1-10 of 59
Type of publication
journal article (52)
conference paper (4)
research review (1)
Type of content
peer-reviewed (49)
other academic/artistic (8)
Author/Editor
Davies, M. (9)
Campain, N (9)
Davies, RJ (9)
Espin-Basany, E (8)
Kim, H. (7)
Abraham-Nordling, M (7)
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Akiyoshi, T (7)
Alberda, W (7)
Albert, M (7)
Andric, M (7)
Antoniou, A (7)
Auer, R (7)
Austin, KK (7)
Baker, RP (7)
Bali, M (7)
Bebington, B (7)
Bednarski, BK (7)
Beets, GL (7)
Berg, PL (7)
Biondo, S (7)
Boyle, K (7)
Bordeianou, L (7)
Bremers, AB (7)
Brunner, M (7)
Bui, A (7)
Burgess, A (7)
Burger, JWA (7)
Carvalhal, S (7)
Castro, L (7)
Chan, KKL (7)
Chew, MH (7)
Christensen, HK (7)
Clouston, H (7)
Colquhoun, AJ (7)
Corr, A (7)
Coscia, M (7)
Damjanovic, L (7)
de Wilt, JHW (7)
Deutsch, C (7)
Dietz, D (7)
Domingo, S (7)
Dozois, EJ (7)
Duff, M (7)
Enrique-Navascues, J ... (7)
Fleming, F (7)
Garcia-Granero, E (7)
Garcia-Sabrido, JL (7)
Gentilini, L (7)
Ghouti, L (7)
Giner, F (7)
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University
Karolinska Institutet (37)
Uppsala University (9)
Lund University (8)
University of Gothenburg (5)
Stockholm University (3)
Linköping University (3)
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Royal Institute of Technology (2)
Örebro University (2)
University of Skövde (2)
Chalmers University of Technology (2)
Umeå University (1)
Mid Sweden University (1)
Högskolan Dalarna (1)
Swedish University of Agricultural Sciences (1)
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Language
English (59)
Research subject (UKÄ/SCB)
Medical and Health Sciences (18)
Natural sciences (10)
Engineering and Technology (1)
Social Sciences (1)

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