| 1. |
- Abdalla, E., et al.
(author)
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Cosmology intertwined : A review of the particle physics, astrophysics, and cosmology associated with the cosmological tensions and anomalies
- 2022
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In: Journal of High Energy Astrophysics. - : Elsevier BV. - 2214-4048 .- 2214-4056. ; 34, s. 49-211
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Journal article (peer-reviewed)abstract
- The standard Λ Cold Dark Matter (ΛCDM) cosmological model provides a good description of a wide range of astrophysical and cosmological data. However, there are a few big open questions that make the standard model look like an approximation to a more realistic scenario yet to be found. In this paper, we list a few important goals that need to be addressed in the next decade, taking into account the current discordances between the different cosmological probes, such as the disagreement in the value of the Hubble constant H0, the σ8–S8 tension, and other less statistically significant anomalies. While these discordances can still be in part the result of systematic errors, their persistence after several years of accurate analysis strongly hints at cracks in the standard cosmological scenario and the necessity for new physics or generalisations beyond the standard model. In this paper, we focus on the 5.0σ tension between the Planck CMB estimate of the Hubble constant H0 and the SH0ES collaboration measurements. After showing the H0 evaluations made from different teams using different methods and geometric calibrations, we list a few interesting new physics models that could alleviate this tension and discuss how the next decade's experiments will be crucial. Moreover, we focus on the tension of the Planck CMB data with weak lensing measurements and redshift surveys, about the value of the matter energy density Ωm, and the amplitude or rate of the growth of structure (σ8,fσ8). We list a few interesting models proposed for alleviating this tension, and we discuss the importance of trying to fit a full array of data with a single model and not just one parameter at a time. Additionally, we present a wide range of other less discussed anomalies at a statistical significance level lower than the H0–S8 tensions which may also constitute hints towards new physics, and we discuss possible generic theoretical approaches that can collectively explain the non-standard nature of these signals. Finally, we give an overview of upgraded experiments and next-generation space missions and facilities on Earth that will be of crucial importance to address all these open questions.
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| 2. |
- Baloukidis, D., et al.
(author)
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A Comparative Assessment of the Distribution of Joule Heating in Altitude as Estimated in TIE-GCM and EISCAT Over One Solar Cycle
- 2023
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In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 128:12
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Journal article (peer-reviewed)abstract
- During geomagnetically active times, Joule (or frictional) heating in the Lower Thermosphere-Ionosphere is a significant source of thermal energy, greatly affecting density, temperature, composition and circulation. At the same time, Joule heating and the associated Pedersen conductivity are amongst the least known parameters in the upper atmosphere in terms of their quantification and spatial distribution, and their parameterization by geomagnetic parameters shows large discrepancies between estimation methodologies, primarily due to a lack of comprehensive measurements in the region where they maximize. In this work we perform a long-term statistical comparison of Joule heating as calculated by the NCAR Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM) and as obtained through radar measurements by the European Incoherent Scatter Scientific Association (EISCAT). Statistical estimates of Joule heating and Pedersen conductivity are obtained from a simulation run over the 11 year period spanning from 2009 until 2019 and from radar measurements over the same period, during times of radar measurements. The results are statistically compared in different Magnetic Local Time sectors and Kp level ranges in terms of median values and percentiles of altitude profiles. It is found that Joule heating and Pedersen conductivity are higher on average in TIE-GCM than in EISCAT for low Kp and are lower than EISCAT for high Kp. It is also found that neutral winds cannot account for the discrepancies between TIE-GCM and EISCAT. Comparisons point toward the need for a Kp-dependent parameterization of Joule heating in TIE-GCM to account for the contribution of small scale effects. During times of high solar activity, Joule (or frictional) heating in the Lower Thermosphere-Ionosphere is a significant source of thermal energy, greatly affecting density, temperature, composition and circulation. Joule heating is largely unknown, due to a lack of measurements in the altitude ranges where it maximizes. In this work we compare Joule heating estimates from the NCAR Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM) and as obtained through radar measurements by the European Incoherent Scatter Scientific Association (EISCAT), from a simulation run over the 11 year period spanning from 2009 until 2019 and from radar measurements over the same period. The results are compared in different Magnetic Local Time sectors and Kp level ranges in terms of median values and percentiles of altitude profiles. It is found that Joule heating and Pedersen conductivity are higher on average in TIE-GCM than in EISCAT for low activity levels and are lower than EISCAT for high activity levels. It is also found that neutral winds cannot account for the discrepancies between TIE-GCM and EISCAT. Comparisons point toward the need for a new parameterization of Joule heating in TIE-GCM to account for the contribution of small scale effects. Joule heating and Pedersen conductivity are calculated in Thermosphere-Ionosphere-Electrodynamics General Circulation Model (TIE-GCM) and European Incoherent Scatter Scientific Association (EISCAT) during solar cycle 24, as a function of Kp, Magnetic Local Time and altitudeJoule heating and Pedersen conductivity in TIE-GCM are under-estimated for high Kp compared to EISCAT measurementsComparisons point toward the need for parameterization of small scale effects in TIE-GCM
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| 3. |
- Grothe, Michel J., 1981, et al.
(author)
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Differential diagnosis of amnestic dementia patients based on an FDG-PET signature of autopsy-confirmed LATE-NC.
- 2022
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In: Alzheimer's & dementia : the journal of the Alzheimer's Association. - : Wiley. - 1552-5279. ; 19:4, s. 1234-44
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Journal article (peer-reviewed)abstract
- Limbic age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is common in advanced age and can underlie a clinical presentation mimicking Alzheimer's disease (AD). We studied whether an autopsy-derived fluorodeoxyglucose positron emission tomography (FDG-PET) signature of LATE-NC provides clinical utility for differential diagnosis of amnestic dementia patients.Ante mortem FDG-PET patterns from autopsy-confirmed LATE-NC (N = 7) and AD (N = 23) patients were used to stratify an independent cohort of clinically diagnosed AD dementia patients (N = 242) based on individual FDG-PET profiles.Autopsy-confirmed LATE-NC and AD groups showed markedly distinct temporo-limbic and temporo-parietal FDG-PET patterns, respectively. Clinically diagnosed AD dementia patients showing a LATE-NC-like FDG-PET pattern (N = 25, 10%) were significantly older, showed less abnormal AD biomarker levels, lower APOE ε4, and higher TMEM106B risk allele load. Clinically, they exhibited a more memory-predominant profile and a generally slower disease course.An autopsy-derived temporo-limbic FDG-PET signature identifies older amnestic patients whose clinical, genetic, and molecular biomarker features are consistent with underlying LATE-NC.
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| 4. |
- Habarulema, John Bosco, et al.
(author)
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Ionospheric Response at Conjugate Locations During the 7-8 September 2017 Geomagnetic Storm Over the Europe-African Longitude Sector
- 2020
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In: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 125:10
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Journal article (peer-reviewed)abstract
- This paper focuses on unique aspects of the ionospheric response at conjugate locations over Europe and South Africa during the 7-8 September 2017 geomagnetic storm including the role of the bottomside and topside ionosphere and plasmasphere in influencing electron density changes. Analysis of total electron content (TEC) on 7 September 2017 shows that for a pair of geomagnetically conjugate locations, positive storm effect was observed reaching about 65% when benchmarked on the monthly median TEC variability in the Northern Hemisphere, while the Southern Hemisphere remained within the quiet time variability threshold of +/- 40%. Over the investigated locations, the Southern Hemisphere midlatitudes showed positive TEC deviations that were in most cases twice the comparative response level in the Northern Hemisphere on the 8 September 2017. During the storm main phase on 8 September 2017, we have obtained an interesting result of ionosonde maximum electron density of the F2 layer and TEC derived from Global Navigation Satellite System (GNSS) observations showing different ionospheric responses over the same midlatitude location in the Northern Hemisphere. In situ electron density measurements from SWARM satellite aided by bottomside ionosonde-derived TEC up to the maximum height of the F2 layer (hmF2) revealed that the bottomside and topside ionosphere as well as plasmasphere electron content contributions to overall GNSS-derived TEC were different in both hemispheres especially for 8 September 2017 during the storm main phase. The differences in hemispheric response at conjugate locations and on a regional scale have been explained in terms of seasonal influence on the background electron density coupled with the presence of large-scale traveling ionospheric disturbances and low-latitude-associated processes. The major highlight of this study is the simultaneous confirmation of most of the previously observed features and their underlying physical mechanisms during geomagnetic storms through a multi-data set examination of hemispheric differences.
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| 5. |
- Ozden, C., et al.
(author)
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FDG Uptake in the Basal Forebrain as Measured by Digital High-Resolution PET Is a Promising Marker of Basal Forebrain Degeneration in the Lewy Body Disease Spectrum A Pilot Study
- 2020
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In: Clinical Nuclear Medicine. - : Ovid Technologies (Wolters Kluwer Health). - 0363-9762 .- 1536-0229. ; 45:4, s. 261-266
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Journal article (peer-reviewed)abstract
- Purpose Cognitive decline in diseases of the Lewy body spectrum (LBS) is linked to dysfunction/degeneration of the basal forebrain (BF). Assessment of glucose metabolism in the BF by FDG PET is hampered by the small size of the BF and limited spatial resolution of conventional PET. This pilot study tested the feasibility of assessing BF glucose metabolism by high-resolution digital PET (dPET). Patients and Methods The retrospective study included 12 LBS patients (61-86 years, 5 demented). Whole-brain stereotactic normalization to anatomical standard space was followed by local stereotactic normalization of a 7 x 7 x 7-cm(3) box around the BF to a custom-made 1 x 1 x 1-mm(3) FDG dPET template. FDG uptake was scaled voxelwise to mean FDG uptake in the pons. Scaled FDG uptake in the BF was compared between demented and nondemented LBS patients and tested for correlation with cortical FDG uptake. Results Scaled FDG uptake in the BF was significantly lower in demented compared with nondemented patients (1.14 +/- 0.09 vs 1.25 +/- 0.06, P = 0.031). Brain-wide voxel-based testing for correlations with scaled FDG uptake in the BF revealed a large cluster comprising medial and ventrolateral frontal cortex, anterior cingulate cortex, insular cortex, and striatum as well as smaller clusters in motor cortex and occipital cortex (P < 0.001, uncorrected). Conclusions These results suggest that dementia-associated BF degeneration in LBS can be sensitively measured as reduced BF FDG uptake on dPET. More accurate delineation of the BF based on individual high-resolution MRI might be useful to make optimal use of improved spatial resolution of dPET and to correct for possible disease- and age-dependent partial volume effects.
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| 6. |
- Palmroth, Minna, et al.
(author)
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Lower-thermosphere-ionosphere (LTI) quantities : current status of measuring techniques and models
- 2021
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In: Annales Geophysicae. - : Copernicus Publications. - 0992-7689 .- 1432-0576. ; 39:1, s. 189-237
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Journal article (peer-reviewed)abstract
- The lower-thermosphere-ionosphere (LTI) system consists of the upper atmosphere and the lower part of the ionosphere and as such comprises a complex system coupled to both the atmosphere below and space above. The atmospheric part of the LTI is dominated by laws of continuum fluid dynamics and chemistry, while the ionosphere is a plasma system controlled by electromagnetic forces driven by the magnetosphere, the solar wind, as well as the wind dynamo. The LTI is hence a domain controlled by many different physical processes. However, systematic in situ measurements within this region are severely lacking, although the LTI is located only 80 to 200 km above the surface of our planet. This paper reviews the current state of the art in measuring the LTI, either in situ or by several different remote-sensing methods. We begin by outlining the open questions within the LTI requiring high-quality in situ measurements, before reviewing directly observable parameters and their most important derivatives. The motivation for this review has arisen from the recent retention of the Daedalus mission as one among three competing mission candidates within the European Space Agency (ESA) Earth Explorer 10 Programme. However, this paper intends to cover the LTI parameters such that it can be used as a background scientific reference for any mission targeting in situ observations of the LTI.
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| 7. |
- Sarris, Theodore E., et al.
(author)
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Daedalus MASE (mission assessment through simulation exercise): A toolset for analysis of in situ missions and for processing global circulation model outputs in the lower thermosphere-ionosphere
- 2023
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In: Frontiers in Astronomy and Space Sciences. - : Frontiers Media SA. - 2296-987X. ; 9
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Journal article (peer-reviewed)abstract
- Daedalus MASE (Mission Assessment through Simulation Exercise) is an open-source package of scientific analysis tools aimed at research in the Lower Thermosphere-Ionosphere (LTI). It was created with the purpose to assess the performance and demonstrate closure of the mission objectives of Daedalus, a mission concept targeting to perform in-situ measurements in the LTI. However, through its successful usage as a mission-simulator toolset, Daedalus MASE has evolved to encompass numerous capabilities related to LTI science and modeling. Inputs are geophysical observables in the LTI, which can be obtained either through in-situ measurements from spacecraft and rockets, or through Global Circulation Models (GCM). These include ion, neutral and electron densities, ion and neutral composition, ion, electron and neutral temperatures, ion drifts, neutral winds, electric field, and magnetic field. In the examples presented, these geophysical observables are obtained through NCAR’s Thermosphere-Ionosphere-Electrodynamics General Circulation Model. Capabilities of Daedalus MASE include: 1) Calculations of products that are derived from the above geophysical observables, such as Joule heating, energy transfer rates between species, electrical currents, electrical conductivity, ion-neutral collision frequencies between all combinations of species, as well as height-integrations of derived products. 2) Calculation and cross-comparison of collision frequencies and estimates of the effect of using different models of collision frequencies into derived products. 3) Calculation of the uncertainties of derived products based on the uncertainties of the geophysical observables, due to instrument errors or to uncertainties in measurement techniques. 4) Routines for the along-orbit interpolation within gridded datasets of GCMs. 5) Routines for the calculation of the global coverage of an in situ mission in regions of interest and for various conditions of solar and geomagnetic activity. 6) Calculations of the statistical significance of obtaining the primary and derived products throughout an in situ mission’s lifetime. 7) Routines for the visualization of 3D datasets of GCMs and of measurements along orbit. Daedalus MASE code is accompanied by a set of Jupyter Notebooks, incorporating all required theory, references, codes and plotting in a user-friendly environment. Daedalus MASE is developed and maintained at the Department for Electrical and Computer Engineering of the Democritus University of Thrace, with key contributions from several partner institutions.
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| 8. |
- Sarris, Theodoros, et al.
(author)
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Plasma-neutral interactions in the lower thermosphere-ionosphere : The need for in situ measurements to address focused questions
- 2023
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In: Frontiers in Astronomy and Space Sciences. - : Frontiers Media SA. - 2296-987X. ; 9
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Research review (peer-reviewed)abstract
- The lower thermosphere-ionosphere (LTI) is a key transition region between Earth's atmosphere and space. Interactions between ions and neutrals maximize within the LTI and in particular at altitudes from 100 to 200 km, which is the least visited region of the near-Earth environment. The lack of in situ co-temporal and co-spatial measurements of all relevant parameters and their elusiveness to most remote-sensing methods means that the complex interactions between its neutral and charged constituents remain poorly characterized to this date. This lack of measurements, together with the ambiguity in the quantification of key processes in the 100-200 km altitude range affect current modeling efforts to expand atmospheric models upward to include the LTI and limit current space weather prediction capabilities. We present focused questions in the LTI that are related to the complex interactions between its neutral and charged constituents. These questions concern core physical processes that govern the energetics, dynamics, and chemistry of the LTI and need to be addressed as fundamental and long-standing questions in this critically unexplored boundary region. We also outline the range of in situ measurements that are needed to unambiguously quantify key LTI processes within this region, and present elements of an in situ concept based on past proposed mission concepts.
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