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- Algers, Staffan, et al.
(author)
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Valuation of road traffic noise profiles
- 2009
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In: 38th International Congress and Exposition on Noise Control Engineering 2009, INTER-NOISE 2009. - 9781615676903 ; , s. 2161-2168
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Conference paper (peer-reviewed)abstract
- Swedish noise values are today based on a study concerning hedonic price values. The valuation of the average noise levels assumes that there is no difference between different noise profiles, i.e. how the noise level varies throughout the day. In order to be able to take appropriate measures towards noise problems, it is important to know to what extent the noise profile matters. The project aims at researching how the noise value depends on the road traffic noise profile. It further aims at studying how values are affected by the type of activity in which the noise disturbance occurs (being out in the garden/try to sleep in the bedroom). Our method is to use stated preference techniques (pair wise choices) to elicit noise profile values. Respondents listen to and evaluate noise profile where we vary the level of background noise, frequency of noise events and the noise level of the events. This paper also discusses possibilities to estimate willingness to pay for changes in different components of noise profiles.
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- Björk, Glenn, et al.
(author)
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A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast.
- 2007
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In: RNA. - : Cold Spring Harbor Laboratory. - 1355-8382 .- 1469-9001. ; 13:8, s. 1245-55
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Journal article (peer-reviewed)abstract
- Transfer RNAs specific for Gln, Lys, and Glu from all organisms (except Mycoplasma) and organelles have a 2-thiouridine derivative (xm(5)s(2)U) as wobble nucleoside. These tRNAs read the A- and G-ending codons in the split codon boxes His/Gln, Asn/Lys, and Asp/Glu. In eukaryotic cytoplasmic tRNAs the conserved constituent (xm(5)-) in position 5 of uridine is 5-methoxycarbonylmethyl (mcm(5)). A protein (Tuc1p) from yeast resembling the bacterial protein TtcA, which is required for the synthesis of 2-thiocytidine in position 32 of the tRNA, was shown instead to be required for the synthesis of 2-thiouridine in the wobble position (position 34). Apparently, an ancient member of the TtcA family has evolved to thiolate U34 in tRNAs of organisms from the domains Eukarya and Archaea. Deletion of the TUC1 gene together with a deletion of the ELP3 gene, which results in the lack of the mcm(5) side chain, removes all modifications from the wobble uridine derivatives of the cytoplasmic tRNAs specific for Gln, Lys, and Glu, and is lethal to the cell. Since excess of the unmodified form of these three tRNAs rescued the double mutant elp3 tuc1, the primary function of mcm(5)s(2)U34 seems to be to improve the efficiency to read the cognate codons rather than to prevent mis-sense errors. Surprisingly, overexpression of the mcm(5)s(2)U-lacking tRNA(Lys) alone was sufficient to restore viability of the double mutant.
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