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Träfflista för sökning "WFRF:(Canepa M.) srt2:(2020-2022)"

Search: WFRF:(Canepa M.) > (2020-2022)

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1.	Canepa, M, et al. (author) Acknowledging the complex puzzle that links heart failure hospitalizations to outcomes. Letter regarding the article 'Readmission and death in patients admitted with new-onset versus worsening of chronic heart failure: insights from a nationwide cohort' 2021 In: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842. ; 23:4, s. 683-683 Journal article (other academic/artistic)
2.	Canepa, M, et al. (author) Temporal Trends of Heart Failure Hospitalizations in Cardiology Versus Noncardiology Wards According to Ejection Fraction: 16-Year Data From the SwedeHF Registry 2022 In: Circulation. Heart failure. - 1941-3297. ; 15:8, s. 765-773 Journal article (peer-reviewed)
3.	Kapelios, CC, et al. (author) Non-cardiology vs. cardiology care of HFrEF patients is biased and associated with lower use of guideline-based care and higher mortality: observations from the Swedish Heart Failure Registry 2021 In: EUROPEAN JOURNAL OF HEART FAILURE. - 1388-9842. ; 23, s. 90-90 Conference paper (other academic/artistic)
4.	Kapelios, CJ, et al. (author) Use of loop diuretics in chronic heart failure: do we adhere to the Hippocratian principle 'do no harm'? 2021 In: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842. ; 23:7, s. 1068-1075 Journal article (peer-reviewed)
5.	Kapelios, CJ, et al. (author) Use of loop diuretics in chronic heart failure: do we adhere to the Hippocratian principle "do no harm"? 2021 In: European journal of heart failure. - : Wiley. - 1879-0844 .- 1388-9842. Journal article (peer-reviewed)
6.	Sainas, Stefano, et al. (author) Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold : SAR of the Aryloxyaryl Moiety 2022 In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 65:19, s. 12701-12724 Journal article (peer-reviewed)abstract In recent years, human dihydroorotate dehydrogenase inhibitors have been associated with acute myelogenous leukemia as well as studied as potent host targeting antivirals. Starting from MEDS433 (IC50 1.2 nM), we kept improving the structure-activity relationship of this class of compounds characterized by 2-hydroxypyrazolo[1,5-a]pyridine scaffold. Using an in silico/crystallography supported design, we identified compound 4 (IC50 7.2 nM), characterized by the presence of a decorated aryloxyaryl moiety that replaced the biphenyl scaffold, with potent inhibition and pro-differentiating abilities on AML THP1 cells (EC50 74 nM), superior to those of brequinar (EC50 249 nM) and boosted when in combination with dipyridamole. Finally, compound 4 has an extremely low cytotoxicity on non-AML cells as well as MEDS433; it has shown a significant antileukemic activity in vivo in a xenograft mouse model of AML.

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Result 1-6 of 6

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Type of publication: journal article (5); conference paper (1)

Type of content: peer-reviewed (4); other academic/artistic (2)

Author/Editor: Lund, LH (5); Canepa, M (5); Savarese, G (4); Kapelios, CJ (4); Benson, L (2); Al-Karadaghi, Salam (1); show more...; Hage, C (1); Saglio, Giuseppe (1); Dahlstrom, U (1); Thorvaldsen, T (1); Vitale, Nicoletta (1); Kapelios, CC (1); Pippione, Agnese C. (1); Sainas, Stefano (1); Boschi, Donatella (1); Piccinini, Marco (1); Lolli, Marco L. (1); Giorgis, Marta (1); Rolando, Barbara (1); Bonanni, Davide (1); Ramondetti, Cristina (1); Buccinnà, Barbara (1); Circosta, Paola (1); Poli, Giulio (1); Alberti, Marta (1); Passoni, Alice (1); Gaidano, Valentina (1); Cignetti, Alessandro (1); Lanno, Alessia (1); Ferraris, Davide M. (1); Canepa, Barbara (1); Rizzi, Menico (1); Miggiano, Riccardo (1); Tuccinardi, Tiziano (1); show less...

University: Karolinska Institutet (5); Lund University (1)

Language: English (6)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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