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Search: WFRF:(Carlsson Anni) > (2022)

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  • Balboa, Diego, et al. (author)
  • Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells.
  • 2022
  • In: Nature Biotechnology. - : Springer Nature. - 1087-0156 .- 1546-1696. ; 40:7, s. 1042-1055
  • Journal article (peer-reviewed)abstract
    • Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the generation of stem-cell-derived islets (SC-islets), no detailed characterization of their functional properties has been conducted. Here, we generated functionally mature SC-islets using an optimized protocol and benchmarked them comprehensively against primary adult islets. Biphasic glucose-stimulated insulin secretion developed during in vitro maturation, associated with cytoarchitectural reorganization and the increasing presence of alpha cells. Electrophysiology, signaling and exocytosis of SC-islets were similar to those of adult islets. Glucose-responsive insulin secretion was achieved despite differences in glycolytic and mitochondrial glucose metabolism. Single-cell transcriptomics of SC-islets in vitro and throughout 6 months of engraftment in mice revealed a continuous maturation trajectory culminating in a transcriptional landscape closely resembling that of primary islets. Our thorough evaluation of SC-islet maturation highlights their advanced degree of functionality and supports their use in further efforts to understand and combat diabetes.
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  • Carlsson, Anni (author)
  • Sweden
  • 2022
  • In: The 2021 Global Review of Constitutional Law. - : EUT Edizioni Università di Trieste. - 9788855113618 - 9780692159163 ; , s. 332-336
  • Book chapter (other academic/artistic)
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