| 1. |
|
|
| 2. |
- Wiman, Bo, et al.
(author)
-
From Climate Risk to Climate Security
- 2000
-
In: From climate risk to climate security. - Kalmar University, and the Swedish Environmental Protection Agency : Högskolan i Kalmar. Avdelningen för naturresurshushållning och Agenda 21 forskning. - 9163092476
-
Book chapter (other academic/artistic)
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
- Lee, Chong S., et al.
(author)
-
Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease
- 2000
-
In: Brain. - 0006-8950. ; 123:7, s. 1365-1379
-
Journal article (peer-reviewed)abstract
- We investigated the role of dopamine neurons in the manifestation of levodopa-induced dyskinesia in a rat model of Parkinson's disease. Daily treatment with a subthreshold dose of levodopa gradually induced abnormal involuntary movements (AIM) in 6-hydroxydopamine-lesioned rats, which included stereotypy and contraversive rotation. After 4 weeks of levodopa treatment, rats with mild and severe AIM were assigned to two treatment subgroups. The graft subgroup received embryonic ventral mesencephalic tissue into the striatum, whilst the sham-graft subgroup received vehicle only. Rats continued to receive levodopa treatment for 3 months post-graft. Brain sections at the level of the basal ganglia were processed for autoradiography using a ligand for dopamine transporter, and in situ hybridization histochemistry for mRNAs encoding postsynaptic markers. Levodopa-induced AIM significantly improved in grafted rats. The severity of AIM correlated inversely with the density of dopamine nerve terminals in the striatum (P < 0.001), with almost no AIM when the density of dopamine nerve terminals was > 10-20% of normal. Embryonic dopamine neuronal grafts normalized not only mRNA expression for preproenkephalin (PPE) in the indirect pathway, but also mRNA expression for prodynorphin (PDyn) in the direct pathway, which was upregulated by levodopa treatment. AIM scores correlated linearly with expression of PPE mRNA in the indirect pathway (P < 0.001) and also with PDyn mRNA in the direct pathway (P < 0.001). We conclude that embryonic dopamine neuronal grafts may improve levodopa-induced dyskinesia by restoring altered activities of postsynaptic neurons, resulting not only from dopamine denervation, but also from levodopa therapy, provided that the density of striatal dopaminergic nerve terminals is restored above a 'threshold' level.
|
|
| 7. |
- Moore, P. R., et al.
(author)
-
Virtual engineering : an integrated approach to agile manufacturing machinery design and control
- 2003
-
In: Mechatronics (Oxford). - : BioMed Central Ltd.. - 0957-4158 .- 1873-4006. ; 13:10, s. 1105-1121
-
Journal article (peer-reviewed)abstract
- A virtual manufacturing approach for designing, programming, testing, verifying and deploying control systems for agile modular manufacturing machinery are proposed in this paper. It introduces the concepts, operations, mechanisms and implementation techniques for integrating simulation environments and distributed control system environments so that the control logic programs that have been programmed and verified in the virtual environment can be seamlessly transferred to the distributed control system environment for controlling the real devices. The approach looks to exploit simulation in a much wider range of applications with great advantages in the design and development of manufacturing machine systems. In particular, it facilitates the verification of the runtime support applications using the simulation model before they are applied to the real system. Mechanisms that allow runtime data to be collected during operation of the real machinery to calibrate the simulation models are also proposed. The system implemented delivers a powerful set of software tools for realising agile modular manufacturing systems.
|
|
| 8. |
|
|
| 9. |
|
|
| 10. |
|
|
