| 1. |
- Schael, S, et al.
(author)
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Precision electroweak measurements on the Z resonance
- 2006
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In: Physics Reports. - : Elsevier BV. - 0370-1573 .- 1873-6270. ; 427:5-6, s. 257-454
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Research review (peer-reviewed)abstract
- We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLID experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, m(Z) and Gamma(Z), and its couplings to fermions, for example the p parameter and the effective electroweak mixing angle for leptons, are precisely measured: m(Z) = 91.1875 +/- 0.0021 GeV, Gamma(Z) = 2.4952 +/- 0.0023 GeV, rho(l) = 1.0050 +/- 0.0010, sin(2)theta(eff)(lept) = 0.23153 +/- 0.00016. The number of light neutrino species is determined to be 2.9840 +/- 0.0082, in agreement with the three observed generations of fundamental fermions. The results are compared to the predictions of the Standard Model (SM). At the Z-pole, electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its SM expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the Z-pole data are also used to predict the mass of the top quark, m(t) = 173(+10)(+13) GeV, and the mass of the W boson, m(W) = 80.363 +/- 0.032 GeV. These indirect constraints are compared to the direct measurements, providing a stringent test of the SM. Using in addition the direct measurements of m(t) and m(W), the mass of the as yet unobserved SM Higgs boson is predicted with a relative uncertainty of about 50% and found to be less than 285 GeV at 95% confidence level. (c) 2006 Elsevier B.V. All rights reserved.
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| 2. |
- Tacon, Lyndal J., et al.
(author)
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The glucocorticoid receptor is overexpressed in malignant adrenocortical tumors
- 2009
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In: Journal of Clinical Endocrinology and Metabolism. - : The Endocrine Society. - 0021-972X .- 1945-7197. ; 94:11, s. 4591-4599
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Journal article (peer-reviewed)abstract
- CONTEXT: Adrenocortical carcinoma (ACC) is a rare tumor with a poor prognosis. The Weiss score is the most widely accepted method for distinguishing an ACC from an adrenocortical adenoma (ACA); however, in borderline cases, accurate diagnosis remains problematic. We recently discovered that the glucocorticoid receptor (GR) gene NR3C1 is significantly up-regulated in ACCs compared with ACAs in global gene expression studies. OBJECTIVE: Our objective was to study GR expression in adrenocortical tumors (ACTs) and to assess its utility as an adjunct to the Weiss score. DESIGN: Microarray analysis, real-time quantitative RT-PCR (qPCR), immunohistochemistry, Western blot, and direct sequencing were performed. RESULTS: Analysis of 28 ACTs by microarray and 49 ACTs by qPCR found NR3C1 expression to be up-regulated in ACCs compared with ACAs (P < 0.001). Western blotting and RT-PCR confirmed the presence of the GRalpha isoform in ACCs, and no mutations were detected on direct sequencing. Immunohistochemistry for GR in an overlapping cohort of ACTs demonstrated strongly positive nuclear staining in 31 of 33 ACCs (94%), with negative staining in 40 of 41 ACAs (98%) (P < 0.001). This finding was validated in an external cohort of ACTs, such that 14 of 18 ACCs (78%) demonstrated positive nuclear staining whereas 32 of 33 ACAs (94%) were negative (P < 0.001). CONCLUSIONS: The immunohistochemical finding of nuclear GR staining identified ACCs with high diagnostic accuracy. We propose that GR immunohistochemistry may complement the Weiss score in the diagnosis of ACC in cases that display borderline histology. The possibility that GR is transcriptionally active in these tumors, and may therefore be a therapeutic target, requires further study.
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| 3. |
- Bravo, J. M., et al.
(author)
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Incorporating Forecasts of Rainfall in Two Hydrologic Models Used for Medium-Range Streamflow Forecasting
- 2009
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In: Journal of Hydrologic Engineering. - 1084-0699. ; 14:5, s. 435-445
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Journal article (peer-reviewed)abstract
- This study reports on the performance of two medium-range streamflow forecast models: (1) a multilayer feed-forward artificial neural network; and (2) a distributed hydrologic model. Quantitative precipitation forecasts were used as input to both models. The Furnas Reservoir on the Rio Grande River was selected as a case study, primarily because of the availability of quantitative precipitation forecasts from the Brazilian Center for Weather Prediction and Climate Studies and due to its importance in the Brazilian hydropower generating system. Streamflow forecasts were calculated for a drainage area of about 51,900 km(2), with lead times up to 12 days, at daily intervals. The Nash-Sutcliffe efficiency index, the root-mean-square error, the mean absolute error, and the mean relative error were used to assess the relative performance of the models. Results showed that the performance of streamflow forecasts was strongly dependent on the quality of quantitative precipitation forecasts used. The artificial neural network (ANN) method seemed to be less sensitive to precipitation forecast error relative to the distributed hydrological model. Hence, the latter presented a better skill in flow forecasting when using the more accurate perfect precipitation forecast. The conceptual hydrological model also demonstrates better forecast skill than ANN models for longer lead times, when the representation of the rainfall-runoff process and of the water storage in the watershed becomes more important than the flow routing along the drainage network. In addition, results obtained by incorporating a quantitative precipitation forecast in both models performed better than the current streamflow obtained by the Brazilian national electric system operator using statistical models which do not utilize information on precipitation, whether observed or forecast.
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| 4. |
- Chou, S.M., et al.
(author)
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Speaker-dependent bimodal integration of Chinese phonemes and letters using multimodal self-organizing networks
- 2007
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In: The 2007 IEEE International Joint Conference on Neural Networks. - Piscataway, NJ : IEEE Communications Society. - 9781424413799 ; , s. 248-253
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Conference paper (peer-reviewed)abstract
- We present a model of integration of auditory and visual information as in the human cortex. More specifically, we demonstrate a possible way in which the phonetic symbols and associated Mandarin Chinese phonemes pronounced by different speakers are mapped onto the model of cortical areas. Our model has been strongly influenced by recent fMRI studies on integration of letters and speech sounds in the human brain. The model is based on multimodal self-organizing networks (MuSoNs) which were introduced in our previous works and proved to be a convenient tool to describe and study mapping and integration of sensory information as in the cortex. The model also shows how phonemes pronounced by different speakers are mapped onto overlapping cortical areas
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| 5. |
- Mansy, Sheref S, et al.
(author)
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Structure and evolutionary analysis of a non-biological ATP-binding protein.
- 2007
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In: Journal of Molecular Biology. - : Elsevier BV. - 0022-2836 .- 1089-8638. ; 371:2, s. 501-13
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Journal article (peer-reviewed)abstract
- We present a structural and functional analysis of the evolutionary optimization of a non-biological protein derived from a library of random amino acid sequences. A series of previously described in vitro selection experiments transformed a low-affinity ancestral sequence into a stably folded, high affinity ATP binding protein structure. While the evolutionarily optimized protein differs from its ancestral sequence through the accumulation of 12 amino acid mutations, the means by which those mutations enhance the stability and functionality of the protein were not well understood. We used a combination of mutagenesis, biochemistry, and NMR spectroscopy to investigate the structural and functional significance of each mutation. We solved the three-dimensional structure of the folding optimized protein by solution NMR, which revealed a fourth strand of the beta-sheet of the alpha/beta-fold that was not observed in an earlier crystallographic analysis of a less stable version of the protein. The structural rigidity of the newly identified beta-strand was confirmed by T1, T2, and heteronuclear nuclear Overhauser enhancement (NOE) measurements. Biochemical experiments were used to examine point mutations that revert the optimized protein back to the ancestral residue at each of the 12 sites. A combination of structural and functional data was then used to interpret the significance of each amino acid mutation. The enhanced ATP affinity was largely due to the emergence of a patch of positive charge density on the protein surface, while the increased solubility resulted from several mutations that increased the hydrophilicity of the protein surface, thereby decreasing protein aggregation. One mutation may stabilize the hydrophobic face of the beta-sheet.
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| 6. |
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| 7. |
- Reisner, W, et al.
(author)
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The physics of nanoconfined DNA
- 2006
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In: Book of abstracts: March Meet of the American Phys Soc, Baltimore, MD, USA (2006).
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Conference paper (peer-reviewed)
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| 8. |
- Udby, L., et al.
(author)
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Magnetic ordering in electronically phase-separated La2-xSrxCuO4+y: Neutron diffraction experiments
- 2009
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In: Physical Review B (Condensed Matter and Materials Physics). - 1098-0121. ; 80:1
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Journal article (peer-reviewed)abstract
- We present results of magnetic neutron diffraction experiments on the codoped superoxygenated La2-xSrxCuO4+y (LSCO+O) system with x=0.09. We find that the magnetic phase is long-range ordered incommensurate antiferromagnetic with a Neacuteel temperature T-N coinciding with the superconducting ordering temperature T-c=40 K. The incommensurability value is consistent with a hole doping of n(h)approximate to 1>8 but in contrast to nonsuperoxygenated La2-xSrxCuO4 with hole doping close to n(h)approximate to 18 the magnetic-order parameter is not field dependent. We attribute this to the magnetic order being fully developed in LSCO+O as in the spin and charge ordered "stripe" compounds La1.48Nd0.40Sr0.12CuO4 and La7/8Ba1/8CuO4.
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