| 1. |
- Barauskas, Justas, et al.
(author)
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Bioadhesive Lipid Compositions : Self-Assembly Structures, Functionality, and Medical Applications
- 2014
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In: Molecular Pharmaceutics. - : American Chemical Society (ACS). - 1543-8384 .- 1543-8392. ; 11:3, s. 895-903
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Journal article (peer-reviewed)abstract
- Lipid-based liquid crystalline compositions of phospholipids and diglycerides have unique bioadhesive properties with several medical applications, as exemplified by a lipid-based medical device indicated for management and relief of intraoral pain. The present paper describes the relation between self-assembly properties of phosphatidyl choline (PC) and glycerol dioleate (GDO) mixtures in the presence of aqueous fluids and functional attributes of the system, including: film formation and bioadhesion, intraoral coverage, acceptance by patients, and potential as a drug delivery system. The phase behavior of PC/GDO was characterized using synchrotron small-angle X-ray scattering. Functional properties, including the presence of study formulations at intraoral surfaces, ease of attachment, taste, and degree of and intraoral pain, were assessed in a crossover clinical pilot study in head and neck cancer patients. An optimum in functional properties was indicated for formulations with a PC/GDO weight ratio of about 35/65, where the lipids form a reversed cubic liquid crystalline micellar phase structure (Fd3m space group) over the relevant temperature range (25-40 degrees C).
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| 2. |
- Zhu, Xi, 1987, et al.
(author)
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An industrial case study on using language workbench technology for realizing model-driven engineering
- 2014
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In: MODELSWARD 2014 - Proceedings of the 2nd International Conference on Model-Driven Engineering and Software Development. - Lisbon : SciTePress. - 9789897580079
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Conference paper (peer-reviewed)abstract
- Model Driven Engineering (MDE) is a proven approach to improve software development processes by automation. However, traditional development of MDE tooling requires a high upfront cost. Recent developments in language workbench technologies promise to significantly reduce these investment costs. By providing domain experts with targeted projections, the speed and quality of delivering customer value is improved. This paper provides results from an industrial case study in the telecommunications domain and compares the value of using a language workbench to traditional MDE technologies. Evaluation of the approach was based on qualitative research strategy which involved a proof of concept implementation and effort estimations by tooling experts. Our results, using the Intentional Domain Workbench, indicate that applying a language workbench promises significant improvements in several aspects of MDE based software development. Most notably in this paper: (1) improved speed in development of domain specific tooling and (2) improved speed in software development process re-engineering.
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