| 1. |
- Glasbey, JC, et al.
(author)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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| 3. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 4. |
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| 5. |
- Khatri, C, et al.
(author)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Journal article (peer-reviewed)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 6. |
- Anand, S., et al.
(author)
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Optical follow-up of the neutron star–black hole mergers S200105ae and S200115j
- 2020
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In: Nature Astronomy. - : Nature Research. - 2397-3366.
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Journal article (peer-reviewed)abstract
- LIGO and Virgo’s third observing run revealed the first neutron star–black hole (NSBH) merger candidates in gravitational waves. These events are predicted to synthesize r-process elements1,2 creating optical/near-infrared ‘kilonova’ emission. The joint gravitational wave and electromagnetic detection of an NSBH merger could be used to constrain the equation of state of dense nuclear matter3, and independently measure the local expansion rate of the Universe4. Here, we present the optical follow-up and analysis of two of the only three high-significance NSBH merger candidates detected to date, S200105ae and S200115j, with the Zwicky Transient Facility5. The Zwicky Transient Facility observed ~48% of S200105ae and ~22% of S200115j’s localization probabilities, with observations sensitive to kilonovae brighter than −17.5 mag fading at 0.5 mag d−1 in the g- and r-bands; extensive searches and systematic follow-up of candidates did not yield a viable counterpart. We present state-of-the-art kilonova models tailored to NSBH systems that place constraints on the ejecta properties of these NSBH mergers. We show that with observed depths of apparent magnitude ~22 mag, attainable in metre-class, wide-field-of-view survey instruments, strong constraints on ejecta mass are possible, with the potential to rule out low mass ratios, high black hole spins and large neutron star radii.
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| 7. |
- Deckers, M., et al.
(author)
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Constraining Type Ia supernova explosions and early flux excesses with the Zwicky Transient Factory
- 2022
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In: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 512:1, s. 1317-1340
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Journal article (peer-reviewed)abstract
- In the new era of time-domain surveys, Type Ia supernovae are being caught sooner after explosion, which has exposed significant variation in their early light curves. Two driving factors for early-time evolution are the distribution of 56Ni in the ejecta and the presence of flux excesses of various causes. We perform an analysis of the largest young SN Ia sample to date. We compare 115 SN Ia light curves from the Zwicky Transient Facility to the TURTLS model grid containing light curves of Chandrasekhar mass explosions with a range of 56Ni masses, 56Ni distributions, and explosion energies. We find that the majority of our observed light curves are well reproduced by Chandrasekhar mass explosion models with a preference for highly extended 56Ni distributions. We identify six SNe Ia with an early-time flux excess in our gr-band data (four ‘blue’ and two ‘red’ flux excesses). We find an intrinsic rate of 18 ± 11 per cent of early flux excesses in SNe Ia at z < 0.07, based on three detected flux excesses out of 30 (10 per cent) observed SNe Ia with a simulated efficiency of 57 per cent. This is comparable to rates of flux excesses in the literature but also accounts for detection efficiencies. Two of these events are mostly consistent with circumstellar material interaction, while the other four have longer lifetimes in agreement with companion interaction and 56Ni-clump models. We find a higher frequency of flux excesses in 91T/99aa-like events (44 ± 13 per cent).
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| 8. |
- Ahumada, T., et al.
(author)
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Discovery and confirmation of the shortest gamma-ray burst from a collapsar
- 2021
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In: Nature Astronomy. - : Springer Nature. - 2397-3366. ; 5:9, s. 917-927
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Journal article (peer-reviewed)abstract
- Gamma-ray bursts (GRBs) are among the brightest and most energetic events in the Universe. The duration and hardness distribution of GRBs has two clusters1, now understood to reflect (at least) two different progenitors2. Short-hard GRBs (SGRBs; T90 < 2 s) arise from compact binary mergers, and long-soft GRBs (LGRBs; T90 > 2 s) have been attributed to the collapse of peculiar massive stars (collapsars)3. The discovery of SN 1998bw/GRB 980425 (ref. 4) marked the first association of an LGRB with a collapsar, and AT 2017gfo (ref. 5)/GRB 170817A/GW170817 (ref. 6) marked the first association of an SGRB with a binary neutron star merger, which also produced a gravitational wave. Here, we present the discovery of ZTF20abwysqy (AT2020scz), a fast-fading optical transient in the Fermi satellite and the Interplanetary Network localization regions of GRB 200826A; X-ray and radio emission further confirm that this is the afterglow. Follow-up imaging (at rest-frame 16.5 days) reveals excess emission above the afterglow that cannot be explained as an underlying kilonova, but which is consistent with being the supernova. Although the GRB duration is short (rest-frame T90 of 0.65 s), our panchromatic follow-up data confirm a collapsar origin. GRB 200826A is the shortest LGRB found with an associated collapsar; it appears to sit on the brink between a successful and a failed collapsar. Our discovery is consistent with the hypothesis that most collapsars fail to produce ultra-relativistic jets.
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| 9. |
- Sollerman, Jesper, et al.
(author)
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The Type II supernova SN 2020jfo in M 61, implications for progenitor system, and explosion dynamics
- 2021
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 655
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Journal article (peer-reviewed)abstract
- We present the discovery and extensive follow-up observations of SN 2020jfo, a Type IIP supernova (SN) in the nearby (14.5 Mpc) galaxy M 61. Optical light curves (LCs) and spectra from the Zwicky Transient Facility (ZTF), complemented with data from Swift/UVOT and near-infrared photometry is presented. These were used to model the 350-day duration bolometric light curve, which exhibits a relatively short (∼65 days) plateau. This implies a moderate ejecta mass (∼5 M⊙) at the time of explosion, whereas the deduced amount of ejected radioactive nickel is ∼0.025 M⊙. An extensive series of spectroscopy is presented, including spectropolarimetric observations. The nebular spectra are dominated by Hα, but also reveal emission lines from oxygen and calcium. Comparisons to synthetic nebular spectra indicate an initial progenitor mass of ∼12 M⊙. We also note the presence of stable nickel in the nebular spectrum, and SN 2020jfo joins a small group of SNe that have inferred super-solar Ni/Fe ratios. Several years of prediscovery data were examined, but no signs of precursor activity were found. Pre-explosion Hubble Space Telescope imaging reveals a probable progenitor star, detected only in the reddest band (MF814W ≈ −5.8) and it is fainter than expected for stars in the 10−15 M⊙ range. There is thus some tension between the LC analysis, the nebular spectral modeling, and the pre-explosion imaging. To compare and contrast, we present two additional core-collapse SNe monitored by the ZTF, which also have nebular Hα-dominated spectra. This illustrates how the absence or presence of an interaction with circumstellar material (CSM) affect both the LCs and in particular the nebular spectra. Type II SN 2020amv has a LC powered by CSM interaction, in particular after ∼40 days when the LC is bumpy and slowly evolving. The late-time spectra show strong Hα emission with a structure suggesting emission from a thin, dense shell. The evolution of the complex three-horn line profile is reminiscent of that observed for SN 1998S. Finally, SN 2020jfv has a poorly constrained early-time LC, but it is of interest because of the transition from a hydrogen-poor Type IIb to a Type IIn, where the nebular spectrum after the light-curve rebrightening is dominated by Hα, although with an intermediate line width.
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| 10. |
- Benson, Tyler W, et al.
(author)
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Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms.
- 2023
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In: bioRxiv : the preprint server for biology.
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Journal article (peer-reviewed)abstract
- UNLABELLED: A common feature in patients with abdominal aortic aneurysms (AAA) is the formation of a nonocclusive intraluminal thrombus (ILT) in regions of aortic dilation. Platelets are known to maintain hemostasis and propagate thrombosis through several redundant activation mechanisms, yet the role of platelet activation in the pathogenesis of AAA associated ILT is still poorly understood. Thus, we sought to investigate how platelet activation impacts the pathogenesis of AAA. Using RNA-sequencing, we identify that the platelet-associated transcripts are significantly enriched in the ILT compared to the adjacent aneurysm wall and healthy control aortas. We found that the platelet specific receptor glycoprotein VI (GPVI) is among the top enriched genes in AAA ILT and is increased on the platelet surface of AAA patients. Examination of a specific indicator of platelet activity, soluble GPVI (sGPVI), in two independent AAA patient cohorts is highly predictive of a AAA diagnosis and associates more strongly with aneurysm growth rate when compared to D-dimer in humans. Finally, intervention with the anti-GPVI antibody (J) in mice with established aneurysms blunted the progression of AAA in two independent mouse models. In conclusion, we show that levels of sGPVI in humans can predict a diagnosis of AAA and AAA growth rate, which may be critical in the identification of high-risk patients. We also identify GPVI as a novel platelet-specific AAA therapeutic target, with minimal risk of adverse bleeding complications, where none currently exist.KEY POINTS: Soluble glycoprotein VI, which is a platelet-derived blood biomarker, predicts a diagnosis of AAA, with high sensitivity and specificity in distinguishing patients with fast from slow-growing AAA.Blockade of glycoprotein VI in mice with established aneurysms reduces AAA progression and mortality, indicating therapeutic potential.
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