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Träfflista för sökning "WFRF:(Cox P.) srt2:(1992-1994)"

Search: WFRF:(Cox P.) > (1992-1994)

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  • Birnir, Bryndis, et al. (author)
  • A combination of human alpha 1 and beta 1 subunits is required for formation of detectable GABA-activated chloride channels in Sf9 cells.
  • 1992
  • In: Proceedings of the Royal Society of London. Biological Sciences. - : The Royal Society. - 0962-8452 .- 1471-2954. ; 250:1329, s. 307-12
  • Journal article (peer-reviewed)abstract
    • The baculovirus expression system was used to produce alpha 1 and beta 1 subunits of the human GABAA receptor in Sf9 cells. In cells infected with both alpha 1 and beta 1 recombinant viruses, GABA elicited an outwardly rectifying chloride current that was blocked by bicuculline and potentiated by pentobarbitone. GABA did not produce detectable currents in cells infected with either alpha 1 or beta 1 recombinant viruses alone. In these cells, and in control (non-infected) Sf9 cells, pentobarbitone depressed the leakage current (Ki = 55 microM). Fluorescently labelled monoclonal antibodies to the alpha 1 subunit showed greater amounts of the alpha 1 subunit in cells infected with only the alpha 1 recombinant virus than in cells co-infected with the alpha 1 and beta 1 recombinant viruses. Fluorescence of the plasma membrane was seen in cells co-infected with the alpha 1 and beta 1 recombinant viruses, but was absent in cells infected with only the alpha 1 recombinant virus. It was concluded that the alpha 1 subunit normally interacts with the beta 1 subunit to be transported to the plasma membrane in Sf9 cells.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Johansson, R. (1)
Auce, A. (1)
Ingemarsson, A. (1)
Birnir, Bryndis (1)
Renberg, P-U (1)
Carlson, R. F. (1)
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Cox, A. J. (1)
Sundberg, O. (1)
Tibell, G. (1)
Zorro, R. (1)
Tierney, M L (1)
Howitt, S M (1)
Cox, G B (1)
Gage, P W (1)
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University
Uppsala University (2)
Language
English (1)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (1)

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