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- Cronhjort, M, et al.
(author)
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Influence of the phosphate balance on the activity distribution of 99mTc-hydroxy-methylene diphosphonate. Experimental studies in the mouse
- 1998
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In: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 39:4, s. 427-433
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Journal article (peer-reviewed)abstract
- Objective: The purpose was to determine whether changes in the phosphate balance have an influence on the distribution of bone-seeking radiopharmaceuticals. Material and Methods: The biodistribution of 99mTc-HDP in mice, intravenously administered under varying conditions, was assessed by removing different organs and estimating their activity in a scintillation counter. Some experiments were also performed with 99mTc-MDP and 99mTc-DPD. Results: After 1 h and 18 h on phosphate-enriched drinking water, the mice showed a strongly increased uptake in all organs/tissues representing background activity and a decrease in the bone uptake. This pattern changed with time. After 6–8 days of phosphate load, we saw a more favourable distribution with a reduction of the background and whole-body activity. Administration of hPTH 1–34 gave rise to an activity distribution similar to that after 6–8 days on phosphate-enriched water. Changing the phosphate balance had less obvious effects on the distribution of 99mTc-MDP and 99mTc-DPD. Conclusion: The activity distribution of bone-seeking radiopharmaceuticals in the mouse is affected by the phosphate balance. The mechanism behind this finding is unknown but it may be partially mediated by PTH. It is possible that changes in the phosphate balance, induced by pharmaceuticals or by dietary changes, may affect the image quality at bone scintigraphy.
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| 4. |
- Cronhjort, M, et al.
(author)
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Sympathotropic drugs and the distribution of 99mTc-hydroxymethylene diphosphonate. Experimental studies in the mouse
- 1999
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In: Acta radiologica (Stockholm, Sweden : 1987). - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 40:3, s. 309-313
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Journal article (peer-reviewed)abstract
- Objective: the uptake of bone-seeking radiopharmaceuticals depends on the blood flow, which is influenced by the sympathetic nervous system. Our aim was to study the effect of sympathomimetic drugs on the distribution of bone-seeking agents. Material and Methods: Various sympathomimetic and β-blocking drugs were injected in mice at different times in relation to the administration of 99mTc-HDP Three hours after this, venous blood and various organs were removed and their activities were related to the administered activity. A kinetic study of the whole-body activity retention after administration of terbutaline was also made. Results: the biodistribution of 99mTc-HDP was similar after the administration of sympathomimetics and of β-antagonists. All drugs gave rise to an increased soft tissue activity and a decreased bone activity, corresponding to a lowered quality of the potential bone scan. Terbutaline gave rise to an increased excretion of 99mTc-HDP. the mechanisms behind the findings cannot be entirely explained. Conclusion: Drug interference with the sympathetic nervous system causes undesirable effects on the biodistribution of 99mTc-HDP in the mouse. Studies in humans are necessary to evaluate whether clinical treatment with sympathotropic drugs affects the bone scintigram.
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