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- Bengtsson, Johan, et al.
(author)
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The effects of uterine artery embolization with a new degradable microsphere in an experimental study
- 2017
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In: Acta Radiologica. - : SAGE Publications. - 0284-1851 .- 1600-0455. ; 58:11, s. 1334-1341
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Journal article (peer-reviewed)abstract
- Background Transarterial particle embolization is a common treatment of uterine fibroids, aiming to obtain ischemia resulting in shrinking of the fibroid with preservation of normal uterine tissue. Embolization with non-degradable microspheres is established, but causes permanent occlusion of the arteries, affecting both the uterus as well as the fibroids. Purpose To evaluate in vivo degradation, local tissue effects, and possible recanalization following intra-arterial deposition of the new, degradable starch microspheres (DSM), in a short-term experimental pilot study. Material and Methods Under general anesthesia, unilateral transarterial embolization of the uterine artery (UA) with DSM 500-700 μm was performed in five female sheep. The animals underwent renewed angiography at different intervals after embolization (19-65 h) and were subsequently sacrificed. Histological examination was performed. Results Embolization with absent flow in the UA could be completed in five of six animals. At final angiographic evaluation, recanalization of the embolized arteries was evident in three sheep. At the gross postmortem examination, edema and discoloration indicating ischemia of the uterus at the embolized side, was observed in all the sheep. At histopathological examination, different stages of DSM degradation in the arterial branches were observed in both endometrium and myometrium. Mild-to-moderate vasculitis and mild-to-extensive ischemic changes were present along with degeneration of the uterine glands. Conclusion This short-term pilot study proved efficacy of embolization with DSM causing ischemic changes in the embolized organ, but also degradation of the DSM with subsequent recanalization of the embolized arteries.
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| 3. |
- Keussen, Inger E., et al.
(author)
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Treatment of the acute severe pulmonary embolism using endovascular methods
- 2018
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In: Polish Journal of Radiology. - : Termedia Sp. z.o.o.. - 1733-134X .- 1899-0967. ; 83, s. 248-252
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Journal article (peer-reviewed)abstract
- Purpose: To present a single-centre experience with endovascular treatment of patients with severe symptoms secondary to acute pulmonary embolism (PE). Material and methods: Twenty-five patients were treated due to contraindications or deficient effects of systemic throbolytic therapy. The patients were treated with a combination of fragmentation and aspiration, only aspiration, only fragmentation, and with catheter-directed thrombolytic therapy. Results: The saturation was improved following treatment in all patients, except in one where the procedure counot be completed. There were no immediate or late procedure-related complications. Conclusions: Endovascular treatment of severe PE is a safe and efficient option in patients with failing effect or contindication to systemic thrombolysis.
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