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- Brink, Mikael, et al.
(author)
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Multiplex Analyses of Antibodies Against Citrullinated Peptides in Individuals Prior to Development of Rheumatoid Arthritis
- 2013
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In: Arthritis and Rheumatism. - : Wiley. - 0004-3591 .- 1529-0131. ; 65:4, s. 899-910
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Journal article (peer-reviewed)abstract
- Objective The presence of antibodies against cyclic citrullinated peptides has been demonstrated to precede the onset of symptoms of rheumatoid arthritis (RA) by several years. The aim of this study was to analyze antibodies against 10 citrullinated autoantigen-derived peptides for reactivity before the onset of RA symptoms. Methods A casecontrol study was conducted within the Medical Biobank of Northern Sweden. The study was performed in 409 individuals, 386 of whom donated 717 blood samples before the onset of symptoms of RA (pre-patients). The median period of time predating the onset of RA was 7.4 years. A total of 1,305 population-based control subjects were also studied. Antibodies to 10 citrullinated peptides, fibrinogen 573 (Fib573), Fib591, Fib3652, Fib72, Fib74, -enolase (citrullinated -enolase peptide 1 [CEP-1]), triple-helical type II collagen peptide C1 (citC1III), filaggrin, vimentin 217 (Vim217), and Vim6075, were analyzed using a microarray system. Results The fluorescence intensity of antibodies against Fib3652, Fib74, CEP-1, citC1III, and filaggrin was significantly increased in pre-patients compared with controls (P < 0.001). The levels of the earliest-detectable antibodies (Fib591 and Vim6075) fluctuated over time, with only a slight increase after the onset of disease. The frequency of antibodies against Fib3652, CEP-1, and filaggrin increased gradually, reaching the highest levels before symptom onset. The frequency of a cluster of antibodies, citC1III, Fib573, and Fib74, increased only slightly before the onset of symptoms but increased prominently after disease onset. The odds ratio for the development of RA in individuals expressing both CEP-1 and Fib3652 antibodies (using data from samples obtained <3.35 years predating symptom onset) was 40.4 (95% confidence interval 19.882.3) compared with having either antibody alone. Conclusion Development of an immune response toward citrullinated peptides is initially restricted but expands with time to induce a more specific response, with levels, particularly those of antibodies against CEP-1, Fib3652, and filaggrin, increasing during the predating time period closer to the onset of symptoms.
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| 4. |
- Dahlqvist, Jörgen, et al.
(creator_code:cre_t)
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Praxis
- 2014
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Artistic work (other academic/artistic)
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| 5. |
- Dahlqvist, Jörgen
(author)
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Stränder
- 2014
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Artistic work (other academic/artistic)
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| 6. |
- Dahlqvist, Peter, et al.
(author)
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Late Ordovician shelly faunas from Jamtland: palaeocommunity development along the margin of the Swedish Caledonides
- 2010
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In: Bulletin of Geosciences. - : Czech Geological Survey. - 1214-1119 .- 1802-8225. ; 85:3, s. 505-512
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Journal article (peer-reviewed)abstract
- Late Ordovician shelly faunas occur at several localities in the Ostersund area of Jamtland (Sweden) and developed against a background of intense and rapid global climate change. In the eastern part, approximately in the middle parts of the Krykas Quartzite, and in the western part in the uppermost Kogsta Siltstone changes in faunas and sedimentary patterns provide regional evidence of these global events. In both areas the faunas occur in shale and siltstone facies and are used to effect correlations between the eastern and western parts of the region, which show major differences in facies development. These sub-basins, situated on the margins of a developing mountain belt, reacted differently to global signals providing further evidence of the heterogeneous responses to climate change at the end of the Ordovician Period.
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