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Träfflista för sökning "WFRF:(Danielson Anders) srt2:(1995-1999)"

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1.	Brånalt, J, et al. (author) A convenient synthesis of 1-(S)-[1'-(S)-(t-butyloxycarbonylamino)-2'-phenylethyl]oxirane : a useful building block in the synthesis of HIV protease inhibitors 1997 In: Tetrahedron Letters. - : Elsevier. - 0040-4039 .- 1359-8562. ; 38:19, s. 3483-3486 Journal article (peer-reviewed)
2.	Bäckbro, Kristina, et al. (author) Cyclic urea and sulfamide-based inhibitors of HIV-1 protease: Changes in binding mode upon modifications in the P1/P1 side chain 1998 In: Antiviral Research. - 0166-3542 .- 1872-9096. ; 37, s. A56-A56 Journal article (peer-reviewed)
3.	Hultén, Johan, et al. (author) Cyclic 7-membered sulfamide HIV-1 protease inhibitors 1998 In: Antiviral Research. - 0166-3542 .- 1872-9096. ; 37, s. A57-A57 Journal article (peer-reviewed)
4.	Hultén, Johan, et al. (author) Cyclic HIV-1 protease inhibitors derived from mannitol : synthesis, inhibitory potencies, and computational predictions of binding affinities 1997 In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 40:6, s. 885-897 Journal article (peer-reviewed)abstract Ten C-2-symmetric cyclic urea and sulfamide derivatives have been synthesized from L-mannonic gamma-lactone and D-mannitol. The results of experimental measurement of their inhibitory potencies against HIV-1 protease were compared to calculated free energies of binding derived from molecular dynamics (MD) simulations. The compounds were selected, firstly, to enable elucidation of the role of stereochemistry for binding affinity (1a-d) and, secondly, to allow evaluation of the effects of variation in the link to the P1 and P1' phenyl groups on affinity (la and 2-5). Thirdly, compounds with hydrogen bond-accepting or -donating groups attached to the phenyl groups in the P2 and P2' side chains (6 and 7) were selected. Binding free energies were estimated by a linear response method, whose predictive power for estimating binding affinities from MD simulations was demonstrated.
5.	Hultén, Johan, et al. (author) Inhibitors of the C(2)-symmetric HIV-1 protease: nonsymmetric binding of asymmetric cyclic sulfamide with ketoxime groups in the P2/P2' side chains 1999 In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 42:20, s. 4054-4061 Journal article (peer-reviewed)
6.	Niklasson, Gunilla, et al. (author) Synthesis of C-2 symmetric potential inhibitors of HIV-1 protease from D-mannitol 1996 In: Journal of carbohydrate chemistry. - : Informa UK Limited. - 0732-8303 .- 1532-2327. ; 15:5, s. 555-569 Journal article (peer-reviewed)
7.	Nöteberg, Daniel, et al. (author) Synthesis of enantiomerically pure cis and trans 2-aminocyclopentanecarboxylic acids. Use of proline replacements in potential HIV-protease inhibitors 1997 In: Tetrahedron. - 0040-4020 .- 1464-5416. ; 53:23, s. 7975-7984 Journal article (peer-reviewed)abstract The synthesis of the four diastereomeric 2-aminocyclopentanecarboxylic acids, their use as replacements for proline in potential HIV protease inhibitors containing a hydroxyethylamine dipeptide isostere and the evaluation of the biological activity of these is described.
8.	Zuccarello, Guido, et al. (author) HIV-1 protease inhibitors based on acyclic carbohydrates 1998 In: Journal of Organic Chemistry. - : American Chemical Society (ACS). - 0022-3263 .- 1520-6904. ; 63:15, s. 4898-4906 Journal article (peer-reviewed)abstract A series of acyclic C2-symmetric HIV protease inhibitors readily accessible from D-mannitol have been developed. Several of the compounds synthesized showed significant in vitro activity against HIV-1 protease.
9.	Alterman, Mathias, et al. (author) Design and fast synthesis of C-terminal duplicated potent C2-symmetric P1/P1'-modified HIV-1 protease inhibitors 1999 In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 42:19, s. 3835-3844 Journal article (peer-reviewed)
10.	Alterman, Mathias, et al. (author) Design and synthesis of new potent C2-symmetric HIV-1 protease inhibitors : Use of L-mannaric acid as a peptidomimetic scaffold 1998 In: Journal of Medicinal Chemistry. - : American Chemical Society (ACS). - 0022-2623 .- 1520-4804. ; 41:20, s. 3782-3792 Journal article (peer-reviewed)

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Result 1-10 of 12

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Type of publication: journal article (12)

Type of content: peer-reviewed (12)

Author/Editor: Hallberg, Anders (11); Classon, Björn (9); Samuelsson, Bertil (8); Karlén, Anders (8); Nillroth, Ulrika (8); Danielson, U. Helena (7); show more...; Hultén, Johan (5); Kvarnström, Ingemar (5); Unge, Torsten (5); Schaal, Wesley (3); Danielson, Helena (2); Danielson, U. Helena ... (2); Vrang, Lotta (2); Alterman, Mathias (2); Andersson, Hans O. (2); Kvarnstrom, Ingemar (2); Markgren, Per-Olof (2); Zuccarello, Guido (2); Bouzide, Abderrahim (2); Niklasson, Gunilla (2); Brånalt, Jonas (1); Ahlsén, Göran (1); Samuelsson, B (1); Åqvist, Johan (1); Garg, Neeraj (1); Lövgren, Seved (1); Björsne, Magnus (1); Mühlman, Anna (1); Andersson, Hans (1); Hansson, Tomas (1); Classon, B. (1); Linde, Torbjörn (1); Sandhagen, Bo (1); Danielson, Bo G. (1); Hägg, Anders (1); Brånalt, J (1); Kvarnstrom, I (1); Bäckbro, Kristina (1); Bonham, Nick M (1); Löwgren, Seved (1); Bonham, Nicholas M (1); Brisander, Magnus (1); Svensson, Stefan C.T ... (1); Mörlin, Claes (1); Nöteberg, Daniel (1); show less...

University: Uppsala University (12)

Language: English (12)

Research subject (UKÄ/SCB): Medical and Health Sciences (7); Natural sciences (4)

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