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- Baldwin, Dare A., et al.
(author)
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Segmenting dynamic human action via statistical structure
- 2008
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In: Cognition. - : Springer. - 0010-0277 .- 1873-7838. ; 106:3, s. 1382-1407
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Journal article (peer-reviewed)abstract
- Human social, cognitive, and linguistic functioning depends on skills for rapidly processing action. Identifying distinct acts within the dynamic motion flow is one basic component of action processing; for example, skill at segmenting action is foundational to action categorization, verb learning, and comprehension of novel action sequences. Yet little is currently known about mechanisms that may subserve action segmentation. The present research documents that adults can register statistical regularities providing clues to action segmentation. This finding provides new evidence that structural knowledge gained by mechanisms such as statistical learning can play a role in action segmentation, and highlights a striking parallel between processing of action and processing in other domains, such as language.
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- Dare, Emma V., et al.
(author)
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Genipin Cross-Linked Fibrin Hydrogels for in vitro Human Articular Cartilage Tissue-Engineered Regeneration
- 2009
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In: Cells Tissues Organs. - : Karger. - 1422-6405 .- 1422-6421. ; 190:6, s. 313-325
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Journal article (peer-reviewed)abstract
- Our objective was to examine the potential of a genipin cross-linked human fibrin hydrogel system as a scaffold for articular cartilage tissue engineering. Human articular chondrocytes were incorporated into modified human fibrin gels and evaluated for mechanical properties, cell viability, gene expression, extracellular matrix production and subcutaneous biodegradation. Genipin, a naturally occurring compound used in the treatment of inflammation, was used as a cross-linker. Genipin cross-linking did not significantly affect cell viability, but significantly increased the dynamic compression and shear moduli of the hydrogel. The ratio of the change in collagen II versus collagen I expression increased more than 8-fold over 5 weeks as detected with real-time RT-PCR. Accumulation of collagen II and aggrecan in hydrogel extracellular matrix was observed after 5 weeks in cell culture. Overall, our results indicate that genipin appeared to inhibit the inflammatory reaction observed 3 weeks after subcutaneous implantation of the fibrin into rats. Therefore, genipin cross-linked fibrin hydrogels can be used as cell-compatible tissue engineering scaffolds for articular cartilage regeneration, for utility in autologous treatments that eliminate the risk of tissue rejection and viral infection.
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