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Träfflista för sökning "WFRF:(Deloukas P) srt2:(2010-2014)"

Search: WFRF:(Deloukas P) > (2010-2014)

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1.	Dupuis, J, et al. (author) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk 2010 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 42:2, s. 105-U32 Journal article (peer-reviewed)
2.	Wood, AR, et al. (author) Defining the role of common variation in the genomic and biological architecture of adult human height 2014 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:11, s. 1173-1186 Journal article (peer-reviewed)
3.	Ehret, GB, et al. (author) Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk 2011 In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 478:7367, s. 103-109 Journal article (peer-reviewed)
4.	Manning, AK, et al. (author) A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance 2012 In: Nature genetics. - New York : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:6, s. 659-U81 Journal article (peer-reviewed)
5.	Tsoi, LC, et al. (author) Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity 2012 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 44:12, s. 1341-1348 Journal article (peer-reviewed)
6.	Mahajan, A, et al. (author) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility 2014 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 46:3, s. 234- Journal article (peer-reviewed)
7.	Speliotes, Elizabeth K., et al. (author) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948 Journal article (peer-reviewed)abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
8.	Sarwar, N, et al. (author) Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies 2010 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 375:9726, s. 1634-1639 Journal article (peer-reviewed)
9.	Butterworth, AS, et al. (author) Large-scale gene-centric analysis identifies novel variants for coronary artery disease 2011 In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404. ; 7:9, s. e1002260- Journal article (peer-reviewed)
10.	Craddock, Nick, et al. (author) Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls 2010 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720 Journal article (peer-reviewed)abstract Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.

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Result 1-10 of 60

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Type of publication: journal article (59); conference paper (1)

Type of content: peer-reviewed (57); other academic/artistic (3)

Author/Editor: Deloukas, Panos (30); Deloukas, P. (28); Groop, Leif (17); Stefansson, Kari (17); Wareham, Nicholas J. (16); Thorsteinsdottir, Un ... (16); show more...; Loos, Ruth J F (16); Salomaa, Veikko (14); McCarthy, Mark I (14); Thorleifsson, Gudmar (14); Gieger, Christian (14); Barroso, Ines (14); Wilson, James F. (14); Hofman, Albert (14); Soranzo, Nicole (13); Campbell, Harry (13); Rudan, Igor (13); Mangino, Massimo (13); Wichmann, H. Erich (13); Peltonen, Leena (13); Gyllensten, Ulf (13); Johnson, Toby (13); Hayward, Caroline (13); Johansson, Åsa (12); Ingelsson, Erik (12); Willemsen, Gonneke (12); Boomsma, Dorret I. (12); Jarvelin, Marjo-Riit ... (12); Uitterlinden, André ... (12); Pouta, Anneli (12); Elliott, Paul (12); Boerwinkle, Eric (12); Lind, Lars (11); Melander, Olle (11); Strachan, David P (11); van Duijn, Cornelia ... (11); Ripatti, Samuli (11); Spector, Tim D. (11); Kaprio, Jaakko (11); Samani, Nilesh J. (11); Froguel, Philippe (11); Luan, Jian'an (11); Metspalu, Andres (11); Hicks, Andrew A. (11); Pramstaller, Peter P ... (11); Wright, Alan F. (11); Zhao, Jing Hua (11); Gudnason, Vilmundur (11); Illig, Thomas (11); Esko, Tõnu (11); show less...

University: Karolinska Institutet (37); Uppsala University (36); Lund University (27); Umeå University (15); University of Gothenburg (14); Örebro University (1); show more...; Linköping University (1); Stockholm School of Economics (1); Högskolan Dalarna (1); show less...

Language: English (60)

Research subject (UKÄ/SCB): Medical and Health Sciences (38); Natural sciences (4)

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