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- Siripanthong, Bhurint, et al.
(author)
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The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
- 2022
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In: JACC: Basic to Translational Science. - : Elsevier BV. - 2452-302X. ; 7:3P1, s. 294-308
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Research review (peer-reviewed)abstract
- The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
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