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Träfflista för sökning "WFRF:(Diab M) srt2:(2010-2014)"

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1.	Scirica, BM, et al. (author) Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus 2013 In: The New England journal of medicine. - 1533-4406. ; 369:14, s. 1317-1326 Journal article (peer-reviewed)
2.	Diab, R, et al. (author) Effect of triple costimulation blockade on islet allograft survival in sensitized mice. 2010 In: Transplantation proceedings. - : Elsevier BV. - 1873-2623 .- 0041-1345. ; 42:6, s. 2109-11 Journal article (other academic/artistic)abstract BACKGROUND: Islet allograft rejection in sensitized recipients is difficult to control by costimulation blockade using anti-CD154 and cytotoxic T-lymphocyte antigen-4 immunoglobulin (CTLA4Ig). Because leukocyte function antigen (LFA) 1 is highly expressed on memory T cells, adding an LFA-1 blockade may inhibit memory T-cell activities. We examined the effects on islet allograft survival of triple costimulation blockade in presensitized recipient mice. METHODS: C57BL/6 mice were sensitized by transplantation under the kidney capsule or intraperitoneal injection of Balb/c islets. Four weeks after transplantation, sensitization was confirmed by flow-cytometric detection of alloreactive antibodies. Diabetes was induced by a single intravenous injection of streptozotocin. Recipients were transplanted with 200 Balb/c islets under the right kidney capsule. Graft function was assessed by daily blood glucose and body weight records. Transplanted animals were divided into 3 treatment groups: group 1, control antibody; group 2, anti-CD154 and CTLA-4 Ig double therapy; group 3, anti-CD154, CTLA4Ig, and anti-LFA-1 triple therapy. Injections were administered every second day from day -2 to day 8. RESULTS: Naïve mice rejected islet allografts between days 7 and 29 (mean 16 +/- 6 d; n = 5), sensitized mice in group 1 between days 0 and 14 (mean 7 +/- 5 d; n = 8), in group 2 between days 4 and 16 (mean 8 +/- 4 d; n = 7), and in group 3 between days 4 and 26 (mean 11 +/- 7 d; n = 10). CONCLUSION: Triple costimulation blockade with anti-CD154, CTLA4Ig, and anti-LFA-1 was not sufficient to improve islet allograft survival in sensitized recipients.
3.	Diab, RA, et al. (author) The Effect of Co-Stimulation Blockade on Memory T Cell Responses in a Rat-To-Mouse Islet Xenotransplantation Model 2012 In: TRANSPLANTATION. - : Ovid Technologies (Wolters Kluwer Health). - 0041-1337. ; 94:10, s. 714-714 Conference paper (other academic/artistic)
4.	Diab, RAH, et al. (author) The effect of costimulation blockade on memory T cell responses in a rat- to mouse islet xenotransplantation model 2011 In: XENOTRANSPLANTATION. - 0908-665X. ; 18:5, s. 292-292 Conference paper (other academic/artistic)
5.	Williams, TD, et al. (author) Transcriptomic responses of European flounder (Platichthys flesus) liver to a brominated flame retardant mixture 2013 In: Aquatic toxicology (Amsterdam, Netherlands). - : Elsevier BV. - 1879-1514 .- 0166-445X. ; 142142-143, s. 45-52 Journal article (peer-reviewed)

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Type of publication: journal article (3); conference paper (2)

Type of content: other academic/artistic (3); peer-reviewed (2)

Author/Editor: Brown, J. (1); Li, Y. (1); Price, D. (1); Walder, J. (1); Wang, J. (1); Lu, J. (1); show more...; Nilsson, J. (1); Albert, M (1); Fischer, H. (1); Conway, J. (1); Moore, R. (1); Jain, S. (1); Robinson, S. (1); Bose, S. (1); Gupta, R. (1); Ma, R. (1); Das, D. (1); Gupta, V. (1); Schneider, R. (1); Horton, K. (1); Wood, J. (1); Hoffman, E. (1); Dellborg, M (1); Bao, Y. (1); Diaz, M. (1); Taylor, R. (1); Weiss, R. (1); Svensson, M. (1); Feldman, R (1); Shah, S (1); Xu, W (1); Tibell, A (1); Chen, J. (1); Rosado, J. (1); Thomas, J. (1); Wood, K. (1); McGill, J (1); Sharma, V. (1); Pearce, M. (1); Osborne, J. (1); Jiang, M. (1); Mehta, P. (1); Anderson, J. (1); Corbascio, M (1); Medina, F (1); Holgersson, Jan (1); Lai, W. (1); Zhao, W. (1); Wu, W. (1); Olsson, A (1); show less...

University: Karolinska Institutet (5); University of Gothenburg (1); Lund University (1)

Language: English (5)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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