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1.	Cable, J, et al. (author) Innovative vaccine approaches-a Keystone Symposia report 2022 In: Annals of the New York Academy of Sciences. - : Wiley. - 1749-6632 .- 0077-8923. ; 1511:1, s. 59-86 Journal article (peer-reviewed)
2.	Haim-Vilmovsky, Liora, et al. (author) Mapping Rora expression in resting and activated CD4+ T cells 2021 In: PLOS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:5 Journal article (peer-reviewed)abstract The transcription factor Rora has been shown to be important for the development of ILC2 and the regulation of ILC3, macrophages and Treg cells. Here we investigate the role of Rora across CD4+ T cells in general, but with an emphasis on Th2 cells, both in vitro as well as in the context of several in vivo type 2 infection models. We dissect the function of Rora using overexpression and a CD4-conditional Rora-knockout mouse, as well as a RORA-reporter mouse. We establish the importance of Rora in CD4+ T cells for controlling lung inflammation induced by Nippostrongylus brasiliensis infection, and have measured the effect on downstream genes using RNA-seq. Using a systematic stimulation screen of CD4 + T cells, coupled with RNA-seq, we identify upstream regulators of Rora, most importantly IL-33 and CCL7. Our data suggest that Rora is a negative regulator of the immune system, possibly through several downstream pathways, and is under control of the local microenvironment. Copyright: © 2021 Haim-Vilmovsky et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Kang, G. (1); Chen, Xi (1); Fisher, Jasmin (1); Klugman, KP (1); Alter, G. (1); Dougan, Gordon (1); show more...; Henriksson, Johan (1); Chiu, C (1); Griffin, Julian L (1); Steer, AC (1); Gordon, SB (1); Rappuoli, R (1); Sandberg, JT (1); Gupta, RK (1); Dougan, G (1); Corey, L (1); Cable, J (1); Klemm, EJ (1); Mutreja, A (1); Wright, GJ (1); Pizza, M (1); Castro, SA (1); Hoffmann, JP (1); Carfi, A (1); Pollard, AJ (1); Krammer, F (1); Wagner, CE (1); Machado, V (1); Modjarrad, K (1); Gilbert, PB (1); Lurie, N (1); Bjorkman, PJ (1); Nemes, E (1); Rudel, T (1); Blish, CA (1); Brennan, K (1); Stuart, LM (1); Madhi, SA (1); Karp, CL (1); Protasio, Anna V. (1); Clare, Simon (1); Teichmann, Sarah A. (1); Haim-Vilmovsky, Lior ... (1); Walker, Jennifer A. (1); Miao, Zhichao (1); Natan, Eviatar (1); Kar, Gozde (1); Barlow, Jillian L. (1); Charidemou, Evelina (1); Mamanova, Lira (1); show less...

University: Umeå University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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