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Search: WFRF:(Efanova IB) > (1998)

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  • Efanova, IB, et al. (author)
  • RX871024 induces Ca2+ mobilization from thapsigargin-sensitive stores in mouse pancreatic beta-cells
  • 1998
  • In: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 47:2, s. 211-218
  • Journal article (peer-reviewed)abstract
    • The effects of RX871024, a compound with an imidazoline structure, on cytoplasmic-free Ca2+ concentration ([Ca2+]i) in mouse pancreatic β-cells were studied. RX871024 modulates [Ca2+]i; by at least two mechanisms. One mechanism involves closure ofATPregulated K+ channels, resulting in membrane depolarization, opening of voltage-gated L-type Ca2+ channels, and a subsequent increase in [Ca2+]i. Another mechanism, reported here for the first time, deals with RX871024-induced mobilization of Ca2+ from nonmitochondrial thapsigargin-sensitive intracellular stores. Reduced glutathione, inhibitors of cytochrome P-450, and monoaminooxidases A and B blocked this Ca2+ mobilization. It is concluded that the mechanism of RX871024-induced Ca2+ mobilization from intracellular stores involves changes in the oxidation/reduction state of the pancreatic β-cell and may be controlled by cytochrome P-450.
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  • Result 1-5 of 5
Type of publication
journal article (5)
Type of content
peer-reviewed (5)
Author/Editor
Efendic, S (5)
Berggren, PO (5)
Zaitsev, SV (5)
Efanova, IB (5)
OSTENSON, CG (3)
Efanov, AM (3)
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Brown, G. (1)
Zhivotovsky, B (1)
Andersson, M (1)
Kohler, M (1)
Mutt, V (1)
Orrenius, S (1)
Juntti-Berggren, L (1)
Mest, HJ (1)
Zhu, SS (1)
Raap, A (1)
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University
Karolinska Institutet (5)
Language
English (5)
Year
1998 (5)Undo refine

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